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Long-term trends in the incidence of heart failure after myocardial infarction.

Publication ,  Journal Article
Velagaleti, RS; Pencina, MJ; Murabito, JM; Wang, TJ; Parikh, NI; D'Agostino, RB; Levy, D; Kannel, WB; Vasan, RS
Published in: Circulation
November 11, 2008

BACKGROUND: Although mortality after myocardial infarction (MI) has declined in the United States in recent decades, there have been few community-based investigations of the long-term trends in the incidence of heart failure after MI, and their results appear to be conflicting. METHODS AND RESULTS: We evaluated 676 Framingham Heart Study participants between 45 and 85 years of age (mean age 67 years, 34% women) who developed a first MI between 1970 and 1999. We assessed the incidence rates of heart failure and of death without heart failure in each of 3 decades (1970 to 1979, 1980 to 1989, and 1990 to 1999). We estimated the multivariable-adjusted risk of events in the latter 2 decades, with the period 1970 to 1979 serving as the referent. The 30-day incidence of heart failure after MI rose from 10% in 1970 to 1979 to 23.1% in 1990 to 1999 (P for trend 0.003), whereas 30-day mortality after MI declined from 12.2% (1970 to 1979) to 4.1% (1990 to 1999). The 5-year incidence of heart failure after MI rose from 27.6% in 1970 to 1979 to 31.9% in 1990 to 1999 (P for trend 0.02), whereas 5-year mortality after MI declined from 41.1% (1970 to 1979) to 17.3% (1990 to 1999). In multivariable analyses, compared with the period 1970 to 1979, we observed higher 30-day (risk ratio 2.05, 95% confidence interval 1.25 to 3.36) and 5-year (risk ratio 1.74, 95% confidence interval 1.07 to 2.84) risks of heart failure in the decade 1990 to 1999. These trends were accompanied by lower 30-day (risk ratio 0.21, 95% confidence interval 0.09 to 0.47) and 5-year (risk ratio 0.31, 95% confidence interval 0.18 to 0.54) mortality rates in 1990 to 1999. CONCLUSIONS: In the present community-based sample, we observed an increase in the incidence of heart failure in recent decades that paralleled the decrease in mortality after MI.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 11, 2008

Volume

118

Issue

20

Start / End Page

2057 / 2062

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Survival Analysis
  • Risk
  • Proportional Hazards Models
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Incidence
  • Humans
 

Citation

APA
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ICMJE
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Velagaleti, R. S., Pencina, M. J., Murabito, J. M., Wang, T. J., Parikh, N. I., D’Agostino, R. B., … Vasan, R. S. (2008). Long-term trends in the incidence of heart failure after myocardial infarction. Circulation, 118(20), 2057–2062. https://doi.org/10.1161/CIRCULATIONAHA.108.784215
Velagaleti, Raghava S., Michael J. Pencina, Joanne M. Murabito, Thomas J. Wang, Nisha I. Parikh, Ralph B. D’Agostino, Daniel Levy, William B. Kannel, and Ramachandran S. Vasan. “Long-term trends in the incidence of heart failure after myocardial infarction.Circulation 118, no. 20 (November 11, 2008): 2057–62. https://doi.org/10.1161/CIRCULATIONAHA.108.784215.
Velagaleti RS, Pencina MJ, Murabito JM, Wang TJ, Parikh NI, D’Agostino RB, et al. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation. 2008 Nov 11;118(20):2057–62.
Velagaleti, Raghava S., et al. “Long-term trends in the incidence of heart failure after myocardial infarction.Circulation, vol. 118, no. 20, Nov. 2008, pp. 2057–62. Pubmed, doi:10.1161/CIRCULATIONAHA.108.784215.
Velagaleti RS, Pencina MJ, Murabito JM, Wang TJ, Parikh NI, D’Agostino RB, Levy D, Kannel WB, Vasan RS. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation. 2008 Nov 11;118(20):2057–2062.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

November 11, 2008

Volume

118

Issue

20

Start / End Page

2057 / 2062

Location

United States

Related Subject Headings

  • United States
  • Time Factors
  • Survival Analysis
  • Risk
  • Proportional Hazards Models
  • Myocardial Infarction
  • Middle Aged
  • Male
  • Incidence
  • Humans