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Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring.

Publication ,  Journal Article
Lieb, W; Pencina, MJ; Wang, TJ; Larson, MG; Lanier, KJ; Benjamin, EJ; Levy, D; Tofler, GH; Meigs, JB; Newton-Cheh, C; Vasan, RS
Published in: Hypertension
August 2008

Children of parents with hypertension are at increased risk of developing high blood pressure. We hypothesize that circulating concentrations of putative biomarkers (that may play a role in development of high blood pressure) are higher in nonhypertensive offspring of parents with hypertension. We compared concentrations of 4 different biomarkers (urinary albumin:creatinine ratio, circulating C-reactive protein, aldosterone:renin ratio, and plasminogen activator inhibitor-1) in nonhypertensive Framingham offspring study participants with none (n=233), 1 (n=474), or both (n=322) parents with hypertension. Parental hypertension was defined as onset before age 60 years, based on longitudinal observations of the original Framingham cohort. Serum C-reactive protein concentrations were higher in nonhypertensive offspring with 1 (median: 1.7; Q1 to Q3: 0.8 to 3.6 mg/L) or both parents with hypertension (median: 1.8; Q1 to Q3: 0.7 to 3.6 mg/L) compared with offspring without parental hypertension (median: 1.4; Q1 to Q3: 0.7 to 3.2 mg/L). In multivariable analyses, parental hypertension was associated with higher serum C-reactive protein concentration in offspring (15% increase per parent with hypertension; P=0.004). Prospectively, the relation of parental hypertension to longitudinal changes in blood pressure in the nonhypertensive offspring was attenuated on adjustment for C-reactive protein (P=0.04 for attenuation). The levels of the other biomarkers evaluated did not significantly differ in offspring according to parental hypertension status. In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk.

Duke Scholars

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

August 2008

Volume

52

Issue

2

Start / End Page

381 / 386

Location

United States

Related Subject Headings

  • Risk Assessment
  • Renin
  • Reference Values
  • Middle Aged
  • Male
  • Incidence
  • Hypertension
  • Humans
  • Genomic Imprinting
  • Genetic Predisposition to Disease
 

Citation

APA
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ICMJE
MLA
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Lieb, W., Pencina, M. J., Wang, T. J., Larson, M. G., Lanier, K. J., Benjamin, E. J., … Vasan, R. S. (2008). Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring. Hypertension, 52(2), 381–386. https://doi.org/10.1161/HYPERTENSIONAHA.108.113589
Lieb, Wolfgang, Michael J. Pencina, Thomas J. Wang, Martin G. Larson, Katherine J. Lanier, Emelia J. Benjamin, Daniel Levy, et al. “Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring.Hypertension 52, no. 2 (August 2008): 381–86. https://doi.org/10.1161/HYPERTENSIONAHA.108.113589.
Lieb W, Pencina MJ, Wang TJ, Larson MG, Lanier KJ, Benjamin EJ, et al. Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring. Hypertension. 2008 Aug;52(2):381–6.
Lieb, Wolfgang, et al. “Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring.Hypertension, vol. 52, no. 2, Aug. 2008, pp. 381–86. Pubmed, doi:10.1161/HYPERTENSIONAHA.108.113589.
Lieb W, Pencina MJ, Wang TJ, Larson MG, Lanier KJ, Benjamin EJ, Levy D, Tofler GH, Meigs JB, Newton-Cheh C, Vasan RS. Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring. Hypertension. 2008 Aug;52(2):381–386.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

August 2008

Volume

52

Issue

2

Start / End Page

381 / 386

Location

United States

Related Subject Headings

  • Risk Assessment
  • Renin
  • Reference Values
  • Middle Aged
  • Male
  • Incidence
  • Hypertension
  • Humans
  • Genomic Imprinting
  • Genetic Predisposition to Disease