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Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.

Publication ,  Journal Article
Ingelsson, E; Pencina, MJ; Tofler, GH; Benjamin, EJ; Lanier, KJ; Jacques, PF; Fox, CS; Meigs, JB; Levy, D; Larson, MG; Selhub, J; Wang, TJ ...
Published in: Circulation
August 28, 2007

BACKGROUND: The metabolic syndrome (MetS) is associated with increased cardiovascular risk. We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors. METHODS AND RESULTS: We measured 8 circulating biomarkers reflecting inflammation (C-reactive protein), hemostasis (plasminogen activator inhibitor-1, fibrinogen), neurohormonal activity (aldosterone, renin, B-type natriuretic peptide, N-terminal proatrial natriuretic peptide), and endothelial dysfunction (homocysteine) in 2292 Framingham Offspring Study participants (mean age, 57 years; 56% women). We related the biomarker panel to incidence of MetS on follow-up initially and then related biomarkers associated with incident MetS to longitudinal change in its components. On follow-up (mean, 2.9 years), 282 participants (of 1473 participants without prevalent MetS at baseline) developed MetS. After adjustment for clinical risk factors, the biomarker panel was associated with incident MetS (P=0.008). On backward elimination, plasminogen activator inhibitor-1 and aldosterone remained associated with incident MetS (multivariable-adjusted odds ratio per 1-SD increment log marker, 1.31 [P=0.004] and 1.21 [P=0.015], respectively). In multivariable analyses evaluating longitudinal change in MetS components (analyzed as continuous variables), plasminogen activator inhibitor-1 was significantly and positively associated with changes in fasting glucose, systolic blood pressure, and triglycerides (all P<0.05). Serum aldosterone was associated positively with change in systolic blood pressure (P=0.023) and inversely with change in high-density lipoprotein cholesterol (P=0.001). CONCLUSIONS: Higher circulating plasminogen activator inhibitor-1 and aldosterone levels are associated with the development of MetS and with longitudinal change of its components, suggesting that these biomarkers and related pathways play a key role in mediating metabolic risk.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

August 28, 2007

Volume

116

Issue

9

Start / End Page

984 / 992

Location

United States

Related Subject Headings

  • Risk Factors
  • Plasminogen Activator Inhibitor 1
  • Metabolic Syndrome
  • Longitudinal Studies
  • Insulin
  • Incidence
  • Humans
  • Follow-Up Studies
  • Child
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
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Ingelsson, E., Pencina, M. J., Tofler, G. H., Benjamin, E. J., Lanier, K. J., Jacques, P. F., … Vasan, R. S. (2007). Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation, 116(9), 984–992. https://doi.org/10.1161/CIRCULATIONAHA.107.708537
Ingelsson, Erik, Michael J. Pencina, Geoffrey H. Tofler, Emelia J. Benjamin, Katherine J. Lanier, Paul F. Jacques, Caroline S. Fox, et al. “Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.Circulation 116, no. 9 (August 28, 2007): 984–92. https://doi.org/10.1161/CIRCULATIONAHA.107.708537.
Ingelsson E, Pencina MJ, Tofler GH, Benjamin EJ, Lanier KJ, Jacques PF, et al. Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation. 2007 Aug 28;116(9):984–92.
Ingelsson, Erik, et al. “Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.Circulation, vol. 116, no. 9, Aug. 2007, pp. 984–92. Pubmed, doi:10.1161/CIRCULATIONAHA.107.708537.
Ingelsson E, Pencina MJ, Tofler GH, Benjamin EJ, Lanier KJ, Jacques PF, Fox CS, Meigs JB, Levy D, Larson MG, Selhub J, D’Agostino RB, Wang TJ, Vasan RS. Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation. 2007 Aug 28;116(9):984–992.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

August 28, 2007

Volume

116

Issue

9

Start / End Page

984 / 992

Location

United States

Related Subject Headings

  • Risk Factors
  • Plasminogen Activator Inhibitor 1
  • Metabolic Syndrome
  • Longitudinal Studies
  • Insulin
  • Incidence
  • Humans
  • Follow-Up Studies
  • Child
  • Cardiovascular System & Hematology