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Characteristics of Framingham offspring participants with long-lived parents.

Publication ,  Journal Article
Terry, DF; Evans, JC; Pencina, MJ; Murabito, JM; Vasan, RS; Wolf, PA; Kelly-Hayes, M; Levy, D; D'Agostino, RB; Benjamin, EJ
Published in: Arch Intern Med
March 12, 2007

BACKGROUND: Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity. METHODS: We studied 1697 Framingham Heart Study (FHS) offspring members 30 years or older, whose parents (1) participated in the original FHS cohort and (2) achieved age 85 years or died before January 1, 2005. Offspring participants (mean +/- SD age, 40 +/- 7 years; 51% women) were grouped according to whether neither (n = 705), one (n = 804), or both parents (n = 188) survived to 85 years or older. We examined offspring risk factors at examination cycle 1 (1971-1975) including age, sex, education, cigarette smoking, systolic and diastolic blood pressures, total-high-density lipoprotein cholesterol ratio, body mass index, and Framingham Risk Score. Participants returning for examination cycle 3 (1983-1987; n = 1319) were eligible for inclusion in longitudinal analyses evaluating risk factor progression from baseline to a higher follow-up risk category. RESULTS: For all factors studied, except body mass index, we observed statistically significant linear trends for lower offspring examination 1 risk factor levels with increasing parental survival category. The mean Framingham Risk Score was most favorable in offspring with both parents surviving to 85 years or older and was progressively worse in those with one or no long-lived parent (0.55, 1.08, and 1.71, respectively; P value for trend, <.001). Longitudinally, offspring of parents who lived longer had lower risk of blood pressure and Framingham Risk Score progression. CONCLUSIONS: Our findings suggest that individuals with long-lived parents have advantageous cardiovascular risk profiles in middle age compared with those whose parents died younger. The risk factor advantage persists over time.

Duke Scholars

Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

March 12, 2007

Volume

167

Issue

5

Start / End Page

438 / 444

Location

United States

Related Subject Headings

  • Survival Rate
  • Smoking
  • Sex Factors
  • Risk Factors
  • Prognosis
  • Parents
  • Massachusetts
  • Male
  • Longevity
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Terry, D. F., Evans, J. C., Pencina, M. J., Murabito, J. M., Vasan, R. S., Wolf, P. A., … Benjamin, E. J. (2007). Characteristics of Framingham offspring participants with long-lived parents. Arch Intern Med, 167(5), 438–444. https://doi.org/10.1001/archinte.167.5.438
Terry, Dellara F., Jane C. Evans, Michael J. Pencina, Joanne M. Murabito, Ramachandran S. Vasan, Philip A. Wolf, Margaret Kelly-Hayes, Daniel Levy, Ralph B. D’Agostino, and Emelia J. Benjamin. “Characteristics of Framingham offspring participants with long-lived parents.Arch Intern Med 167, no. 5 (March 12, 2007): 438–44. https://doi.org/10.1001/archinte.167.5.438.
Terry DF, Evans JC, Pencina MJ, Murabito JM, Vasan RS, Wolf PA, et al. Characteristics of Framingham offspring participants with long-lived parents. Arch Intern Med. 2007 Mar 12;167(5):438–44.
Terry, Dellara F., et al. “Characteristics of Framingham offspring participants with long-lived parents.Arch Intern Med, vol. 167, no. 5, Mar. 2007, pp. 438–44. Pubmed, doi:10.1001/archinte.167.5.438.
Terry DF, Evans JC, Pencina MJ, Murabito JM, Vasan RS, Wolf PA, Kelly-Hayes M, Levy D, D’Agostino RB, Benjamin EJ. Characteristics of Framingham offspring participants with long-lived parents. Arch Intern Med. 2007 Mar 12;167(5):438–444.

Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

March 12, 2007

Volume

167

Issue

5

Start / End Page

438 / 444

Location

United States

Related Subject Headings

  • Survival Rate
  • Smoking
  • Sex Factors
  • Risk Factors
  • Prognosis
  • Parents
  • Massachusetts
  • Male
  • Longevity
  • Incidence