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Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study.

Publication ,  Journal Article
Fox, CS; Pencina, MJ; Meigs, JB; Vasan, RS; Levitzky, YS; D'Agostino, RB
Published in: Circulation
June 27, 2006

BACKGROUND: Recent studies indicate that the prevalence of type 2 diabetes mellitus is increasing in the United States; less is known about trends in the incidence of type 2 diabetes mellitus. METHODS AND RESULTS: Participants free of diabetes mellitus (n=3104; mean age 47 years; 1587 women) from the Framingham Offspring Study who attended a routine examination in the 1970s, 1980s, or 1990s were followed up for the 8-year incidence of diabetes mellitus. Diabetes was defined as a fasting plasma glucose > or = 7.0 mmol/L or treatment with either insulin or a hypoglycemic agent. Pooled logistic regression was used to compare diabetes incidence across decades for participants between 40 and 55 years of age in each decade. The age-adjusted 8-year incidence rate of diabetes was 2.0%, 3.0%, and 3.7% among women and 2.7%, 3.6%, and 5.8% among men in the 1970s, 1980s, and 1990s, respectively. Compared with the 1970s, the age- and sex-adjusted odds ratio (OR) for diabetes was 1.40 (95% confidence interval [CI], 0.89 to 2.22) in the 1980s and 2.05 (95% CI, 1.33 to 3.14) in the 1990s (P for trend=0.0006). Among women, the OR was 1.50 (95% CI, 0.75 to 2.98) in the 1980s and 1.84 (95% CI, 0.95 to 3.55) in the 1990s (P for trend=0.07) compared with the 1970s, whereas among men, the OR was 1.33 (95% CI, 0.72 to 2.47) in the 1980s and 2.21 (95% CI, 1.25 to 3.90) in the 1990s (P for trend=0.003). Most of the increase in absolute incidence of diabetes occurred in individuals with body mass index > or = 30 kg/m2 (P for trend=0.03). CONCLUSIONS: In the present community-based sample of middle-aged adults, we observed a doubling in the incidence of type 2 diabetes over the last 30 years. Careful surveillance of changes in diabetes incidence may be necessary if current trends of excess adiposity continue.

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

June 27, 2006

Volume

113

Issue

25

Start / End Page

2914 / 2918

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Retrospective Studies
  • Regression Analysis
  • Odds Ratio
  • Obesity
  • Middle Aged
  • Massachusetts
  • Male
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fox, C. S., Pencina, M. J., Meigs, J. B., Vasan, R. S., Levitzky, Y. S., & D’Agostino, R. B. (2006). Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation, 113(25), 2914–2918. https://doi.org/10.1161/CIRCULATIONAHA.106.613828
Fox, Caroline S., Michael J. Pencina, James B. Meigs, Ramachandran S. Vasan, Yamini S. Levitzky, and Ralph B. D’Agostino. “Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study.Circulation 113, no. 25 (June 27, 2006): 2914–18. https://doi.org/10.1161/CIRCULATIONAHA.106.613828.
Fox CS, Pencina MJ, Meigs JB, Vasan RS, Levitzky YS, D’Agostino RB. Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation. 2006 Jun 27;113(25):2914–8.
Fox, Caroline S., et al. “Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study.Circulation, vol. 113, no. 25, June 2006, pp. 2914–18. Pubmed, doi:10.1161/CIRCULATIONAHA.106.613828.
Fox CS, Pencina MJ, Meigs JB, Vasan RS, Levitzky YS, D’Agostino RB. Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation. 2006 Jun 27;113(25):2914–2918.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

June 27, 2006

Volume

113

Issue

25

Start / End Page

2914 / 2918

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Retrospective Studies
  • Regression Analysis
  • Odds Ratio
  • Obesity
  • Middle Aged
  • Massachusetts
  • Male
  • Incidence