Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study.

Publication ,  Journal Article
Dhingra, R; Pencina, MJ; Wang, TJ; Nam, B-H; Benjamin, EJ; Levy, D; Larson, MG; Kannel, WB; D'Agostino, RB; Vasan, RS
Published in: Hypertension
May 2006

Prolonged electrocardiographic QRS duration is frequently observed in congestive heart failure (CHF) patients. We hypothesized that CHF risk increases with longer QRS interval in individuals free of CHF. We evaluated 1759 Framingham Study participants (mean age, 69 years; 63% women) without prior myocardial infarction or CHF who attended a routine examination. QRS duration was analyzed as a continuous (log-transformed) and a categorical variable [referent, <100 ms; incomplete bundle branch block (BBB), 100 to 119 ms; complete BBB, > or =120 ms]. During follow-up (mean, 12.7 years), 324 participants (205 women) developed CHF. CHF incidence increased across the 3 baseline QRS duration categories in both sexes. Each SD increment in log-QRS duration was associated with a multivariable-adjusted 23% increase in CHF risk [95% confidence interval [CI] 8% to 38%; P<0.001]. In time- dependent models with QRS category and risk factors updated every 2 years, incomplete BBB was associated with a 1.4-fold (95% CI, 1.05 to 1.96; P=0.03) and complete BBB with a 1.7-fold (95% CI, 1.28 to 2.35; P<0.001) risk of CHF. These associations were maintained on adjustment for baseline left ventricular mass. In our community-based sample, longer electrocardiographic QRS was associated with increased CHF risk, consistent with the hypothesis that depolarization delay may increase CHF risk.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

May 2006

Volume

47

Issue

5

Start / End Page

861 / 867

Location

United States

Related Subject Headings

  • Risk Factors
  • Models, Cardiovascular
  • Middle Aged
  • Male
  • Incidence
  • Humans
  • Heart Failure
  • Heart
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dhingra, R., Pencina, M. J., Wang, T. J., Nam, B.-H., Benjamin, E. J., Levy, D., … Vasan, R. S. (2006). Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study. Hypertension, 47(5), 861–867. https://doi.org/10.1161/01.HYP.0000217141.20163.23
Dhingra, Ravi, Michael J. Pencina, Thomas J. Wang, Byung-Ho Nam, Emelia J. Benjamin, Daniel Levy, Martin G. Larson, William B. Kannel, Ralph B. D’Agostino, and Ramachandran S. Vasan. “Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study.Hypertension 47, no. 5 (May 2006): 861–67. https://doi.org/10.1161/01.HYP.0000217141.20163.23.
Dhingra R, Pencina MJ, Wang TJ, Nam B-H, Benjamin EJ, Levy D, et al. Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study. Hypertension. 2006 May;47(5):861–7.
Dhingra, Ravi, et al. “Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study.Hypertension, vol. 47, no. 5, May 2006, pp. 861–67. Pubmed, doi:10.1161/01.HYP.0000217141.20163.23.
Dhingra R, Pencina MJ, Wang TJ, Nam B-H, Benjamin EJ, Levy D, Larson MG, Kannel WB, D’Agostino RB, Vasan RS. Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study. Hypertension. 2006 May;47(5):861–867.

Published In

Hypertension

DOI

EISSN

1524-4563

Publication Date

May 2006

Volume

47

Issue

5

Start / End Page

861 / 867

Location

United States

Related Subject Headings

  • Risk Factors
  • Models, Cardiovascular
  • Middle Aged
  • Male
  • Incidence
  • Humans
  • Heart Failure
  • Heart
  • Follow-Up Studies
  • Female