Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Liver lesions: manganese-enhanced MR and dual-phase helical CT for preoperative detection and characterization comparison with receiver operating characteristic analysis.

Publication ,  Journal Article
Braga, HJV; Choti, MA; Lee, VS; Paulson, EK; Siegelman, ES; Bluemke, DA
Published in: Radiology
May 2002

PURPOSE: The purpose of this study was to compare, by means of receiver operating characteristic (ROC) analysis, dual-phase helical computed tomography (CT) and manganese-enhanced magnetic resonance (MR) imaging in the detection and characterization of hepatic lesions in patients prior to surgery. MATERIALS AND METHODS: Twenty-five patients known to have or suspected of having hepatic lesions who were eligible for surgery underwent dual-phase (ie, arterial and portal phase) helical CT and phased-array MR imaging (ie, unenhanced fast spin-echo T2-weighted imaging and gradient-echo T1-weighted imaging performed before and after administration of mangafodipir trisodium). All images were reviewed independently by three off-site blinded reviewers who separately reviewed the CT scans and MR images. The standard of reference was findings at surgery, intraoperative ultrasonography (US), and histopathologic examination. ROC curves were established to analyze the results for each reader and modality. RESULTS: Ninety-four lesions (77 malignant and 17 benign) were revealed at surgery, intraoperative US, and/or histopathologic examination. The overall rate of lesion detection for the three readers at CT was 81.9% +/- 7.8, 90.4% +/- 5.9, and 76.6% +/- 8.6. At MR imaging, the detection rates were 72.3% +/- 9.0, 71.3% +/- 9.1, and 69.1% +/- 9.3 (P =.001 for the difference between MR and CT). The average rate of false-positive diagnoses in patients was 14.1% at CT and 6.4% at MR imaging (P =.06 for the difference between MR and CT). The mean areas under the alternative-free-response ROC curves were 0.74 for MR and 0.72 for CT (P =.751, not significant). CONCLUSION: In detection and characterization of liver lesions, manganese-enhanced MR imaging and dual-phase helical CT were not statistically different.

Duke Scholars

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

May 2002

Volume

223

Issue

2

Start / End Page

525 / 531

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sensitivity and Specificity
  • ROC Curve
  • Pyridoxal Phosphate
  • Preoperative Care
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Diseases
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Braga, H. J. V., Choti, M. A., Lee, V. S., Paulson, E. K., Siegelman, E. S., & Bluemke, D. A. (2002). Liver lesions: manganese-enhanced MR and dual-phase helical CT for preoperative detection and characterization comparison with receiver operating characteristic analysis. Radiology, 223(2), 525–531. https://doi.org/10.1148/radiol.2232010908
Braga, Helio J. V., Michael A. Choti, Vivian S. Lee, Erik K. Paulson, Evan S. Siegelman, and David A. Bluemke. “Liver lesions: manganese-enhanced MR and dual-phase helical CT for preoperative detection and characterization comparison with receiver operating characteristic analysis.Radiology 223, no. 2 (May 2002): 525–31. https://doi.org/10.1148/radiol.2232010908.
Braga, Helio J. V., et al. “Liver lesions: manganese-enhanced MR and dual-phase helical CT for preoperative detection and characterization comparison with receiver operating characteristic analysis.Radiology, vol. 223, no. 2, May 2002, pp. 525–31. Pubmed, doi:10.1148/radiol.2232010908.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

May 2002

Volume

223

Issue

2

Start / End Page

525 / 531

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Sensitivity and Specificity
  • ROC Curve
  • Pyridoxal Phosphate
  • Preoperative Care
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Diseases