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Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations.

Publication ,  Journal Article
Meeker, JD; Cooper, EM; Stapleton, HM; Hauser, R
Published in: Environmental health perspectives
May 2013

A reduction in the use of polybrominated diphenyl ethers (PBDEs) because of human health concerns may result in an increased use of and human exposure to organophosphate flame retardants (OPFRs). Human exposure and health studies of OPFRs are lacking.We sought to define the degree of temporal variability in urinary OPFR metabolites in order to inform epidemiologic study design, and to explore a potential primary source of exposure by examining the relationship between OPFRs in house dust and their metabolites in urine.Nine repeated urine samples were collected from 7 men over the course of 3 months and analyzed for bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosphate (DPP), metabolites of the OPFRs tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), respectively. Intraclass correlation coefficients (ICCs) were calculated to characterize temporal reliability. Paired house dust and urine samples were collected from 45 men.BDCPP was detected in 91% of urine samples, and DPP in 96%. Urinary BDCPP showed moderate-to-strong temporal reliability (ICC range, 0.55-0.72). ICCs for DPP were lower, but moderately reliable (range, 0.35-0.51). There was a weak [Spearman r (r(S)) = 0.31] but significant (p = 0.03) correlation between urinary BDCPP and TDCPP concentrations in house dust that strengthened when nondetects (r(S) = 0.47) were excluded. There was no correlation between uncorrected DPP and TPP measured in house dust (r(S) < 0.1).Household dust may be an important source of exposure to TDCPP but not TPP. Urinary concentrations of BDCPP and DPP were moderately to highly reliable within individuals over 3 months.

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Published In

Environmental health perspectives

DOI

EISSN

1552-9924

ISSN

0091-6765

Publication Date

May 2013

Volume

121

Issue

5

Start / End Page

580 / 585

Related Subject Headings

  • Toxicology
  • Organophosphorus Compounds
  • Organophosphonates
  • Organophosphates
  • Middle Aged
  • Male
  • Humans
  • Flame Retardants
  • Environmental Monitoring
  • Dust
 

Citation

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ICMJE
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Meeker, J. D., Cooper, E. M., Stapleton, H. M., & Hauser, R. (2013). Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations. Environmental Health Perspectives, 121(5), 580–585. https://doi.org/10.1289/ehp.1205907
Meeker, John D., Ellen M. Cooper, Heather M. Stapleton, and Russ Hauser. “Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations.Environmental Health Perspectives 121, no. 5 (May 2013): 580–85. https://doi.org/10.1289/ehp.1205907.
Meeker JD, Cooper EM, Stapleton HM, Hauser R. Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations. Environmental health perspectives. 2013 May;121(5):580–5.
Meeker, John D., et al. “Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations.Environmental Health Perspectives, vol. 121, no. 5, May 2013, pp. 580–85. Epmc, doi:10.1289/ehp.1205907.
Meeker JD, Cooper EM, Stapleton HM, Hauser R. Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations. Environmental health perspectives. 2013 May;121(5):580–585.

Published In

Environmental health perspectives

DOI

EISSN

1552-9924

ISSN

0091-6765

Publication Date

May 2013

Volume

121

Issue

5

Start / End Page

580 / 585

Related Subject Headings

  • Toxicology
  • Organophosphorus Compounds
  • Organophosphonates
  • Organophosphates
  • Middle Aged
  • Male
  • Humans
  • Flame Retardants
  • Environmental Monitoring
  • Dust