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Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.

Publication ,  Journal Article
Asada, Y; Sukemori, A; Watanabe, T; Malla, KJ; Yoshikawa, T; Li, W; Kuang, X; Koike, K; Chen, C-H; Akiyama, T; Qian, K; Nakagawa-Goto, K ...
Published in: J Nat Prod
May 24, 2013

Five novel tigliane-type diterpenes, stelleracins A-E (3-7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from the roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3-5 showed potent anti-HIV activity (EC90 0.00056-0.0068 μM) and relatively low or no cytotoxicity (IC50 4.4-17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates.

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Published In

J Nat Prod

DOI

EISSN

1520-6025

Publication Date

May 24, 2013

Volume

76

Issue

5

Start / End Page

852 / 857

Location

United States

Related Subject Headings

  • Thymelaeaceae
  • Plant Roots
  • Nuclear Magnetic Resonance, Biomolecular
  • Nepal
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • Flavanones
  • Diterpenes
  • Cell Survival
  • Anti-HIV Agents
 

Citation

APA
Chicago
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MLA
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Asada, Y., Sukemori, A., Watanabe, T., Malla, K. J., Yoshikawa, T., Li, W., … Lee, K.-H. (2013). Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme. J Nat Prod, 76(5), 852–857. https://doi.org/10.1021/np300815t
Asada, Yoshihisa, Aya Sukemori, Takashi Watanabe, Kuber J. Malla, Takafumi Yoshikawa, Wei Li, Xinzhu Kuang, et al. “Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.J Nat Prod 76, no. 5 (May 24, 2013): 852–57. https://doi.org/10.1021/np300815t.
Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, et al. Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme. J Nat Prod. 2013 May 24;76(5):852–7.
Asada, Yoshihisa, et al. “Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme.J Nat Prod, vol. 76, no. 5, May 2013, pp. 852–57. Pubmed, doi:10.1021/np300815t.
Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Kuang X, Koike K, Chen C-H, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lu Y, Lee K-H. Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme. J Nat Prod. 2013 May 24;76(5):852–857.
Journal cover image

Published In

J Nat Prod

DOI

EISSN

1520-6025

Publication Date

May 24, 2013

Volume

76

Issue

5

Start / End Page

852 / 857

Location

United States

Related Subject Headings

  • Thymelaeaceae
  • Plant Roots
  • Nuclear Magnetic Resonance, Biomolecular
  • Nepal
  • Molecular Structure
  • Medicinal & Biomolecular Chemistry
  • Flavanones
  • Diterpenes
  • Cell Survival
  • Anti-HIV Agents