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Risk factors for febrile status epilepticus: a case-control study.

Publication ,  Journal Article
Hesdorffer, DC; Shinnar, S; Lewis, DV; Nordli, DR; Pellock, JM; Moshé, SL; Shinnar, RC; Litherland, C; Bagiella, E; Frank, LM; Bello, JA ...
Published in: J Pediatr
October 2013

OBJECTIVE: To identify risk factors for developing a first febrile status epilepticus (FSE) among children with a first febrile seizure (FS). STUDY DESIGN: Cases were children with a first FS that was FSE drawn from the Consequences of Prolonged Febrile Seizures in Childhood and Columbia cohorts. Controls were children with a first simple FS and separately, children with a first complex FS that was not FSE. Identical questionnaires were administered to family members of the 3 cohorts. Magnetic resonance imaging protocol and readings were consistent across cohorts, and seizure phenomenology was assessed by the same physicians. Risk factors were analyzed using logistic regression. RESULTS: Compared with children with simple FS, FSE was associated with younger age, lower temperature, longer duration (1-24 hours) of recognized temperature before FS, female sex, structural temporal lobe abnormalities, and first-degree family history of FS. Compared with children with other complex FS, FSE was associated with low temperature and longer duration (1-24 hours) of temperature recognition before FS. Risk factors for complex FS that was not FSE were similar in magnitude to those for FSE but only younger age was significant. CONCLUSIONS: Among children with a first FS, FSE appears to be due to a combination of lower seizure threshold (younger age and lower temperatures) and impaired regulation of seizure duration. Clinicians evaluating FS should be aware of these factors as many episodes of FSE go unnoticed. Further work is needed to develop strategies to prevent FSE.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

October 2013

Volume

163

Issue

4

Start / End Page

1147 / 51.e1

Location

United States

Related Subject Headings

  • Time Factors
  • Surveys and Questionnaires
  • Status Epilepticus
  • Seizures, Febrile
  • Risk Factors
  • Regression Analysis
  • Pediatrics
  • Odds Ratio
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
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ICMJE
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Hesdorffer, D. C., Shinnar, S., Lewis, D. V., Nordli, D. R., Pellock, J. M., Moshé, S. L., … Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) Study Team, . (2013). Risk factors for febrile status epilepticus: a case-control study. J Pediatr, 163(4), 1147-51.e1. https://doi.org/10.1016/j.jpeds.2013.05.038
Hesdorffer, Dale C., Shlomo Shinnar, Darrell V. Lewis, Douglas R. Nordli, John M. Pellock, Solomon L. Moshé, Ruth C. Shinnar, et al. “Risk factors for febrile status epilepticus: a case-control study.J Pediatr 163, no. 4 (October 2013): 1147-51.e1. https://doi.org/10.1016/j.jpeds.2013.05.038.
Hesdorffer DC, Shinnar S, Lewis DV, Nordli DR, Pellock JM, Moshé SL, et al. Risk factors for febrile status epilepticus: a case-control study. J Pediatr. 2013 Oct;163(4):1147-51.e1.
Hesdorffer, Dale C., et al. “Risk factors for febrile status epilepticus: a case-control study.J Pediatr, vol. 163, no. 4, Oct. 2013, pp. 1147-51.e1. Pubmed, doi:10.1016/j.jpeds.2013.05.038.
Hesdorffer DC, Shinnar S, Lewis DV, Nordli DR, Pellock JM, Moshé SL, Shinnar RC, Litherland C, Bagiella E, Frank LM, Bello JA, Chan S, Masur D, Macfall J, Sun S, Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT) Study Team. Risk factors for febrile status epilepticus: a case-control study. J Pediatr. 2013 Oct;163(4):1147–51.e1.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

October 2013

Volume

163

Issue

4

Start / End Page

1147 / 51.e1

Location

United States

Related Subject Headings

  • Time Factors
  • Surveys and Questionnaires
  • Status Epilepticus
  • Seizures, Febrile
  • Risk Factors
  • Regression Analysis
  • Pediatrics
  • Odds Ratio
  • Male
  • Magnetic Resonance Imaging