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Trends in the association of parental history of obesity over 60 years.

Publication ,  Journal Article
Fox, CS; Pencina, MJ; Heard-Costa, NL; Shrader, P; Jaquish, C; O'Donnell, CJ; Vasan, RS; Cupples, LA; D'Agostino, RB
Published in: Obesity (Silver Spring)
March 2014

OBJECTIVE: The association of familial as compared to genetic factors in the current obesogenic environment, compared with earlier, leaner time periods, is uncertain. METHODS: Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-replicated single nucleotide polymorphisms for BMI was examined in association with BMI levels in 1948, 1971, and 2002. RESULTS: BMI was 1.49 kg/m2 higher per each affected parent among the Offspring, and increased to 2.09 kg/m2 higher among the Third Generation participants (P-value for the cohort comparison=0.007). Parental history of obesity was associated with increased weight gain (P < 0.0001) and incident obesity (P = 0.009). Despite a stronger association of parental obesity with offspring BMI in more contemporary time periods, we observed no change in the effect size of a BMI genetic risk score from 1948 to 2002 (P = 0.11 for test of trend across the time periods). CONCLUSIONS: The association of parental obesity has become stronger in more contemporary time period, whereas the association of a BMI genetic risk score has not changed.

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Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

March 2014

Volume

22

Issue

3

Start / End Page

919 / 924

Location

United States

Related Subject Headings

  • Weight Gain
  • United States
  • Risk Factors
  • Prevalence
  • Parents
  • Obesity
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fox, C. S., Pencina, M. J., Heard-Costa, N. L., Shrader, P., Jaquish, C., O’Donnell, C. J., … D’Agostino, R. B. (2014). Trends in the association of parental history of obesity over 60 years. Obesity (Silver Spring), 22(3), 919–924. https://doi.org/10.1002/oby.20564
Fox, Caroline S., Michael J. Pencina, Nancy L. Heard-Costa, Peter Shrader, Cashell Jaquish, Christopher J. O’Donnell, Ramachandran S. Vasan, L Adrienne Cupples, and Ralph B. D’Agostino. “Trends in the association of parental history of obesity over 60 years.Obesity (Silver Spring) 22, no. 3 (March 2014): 919–24. https://doi.org/10.1002/oby.20564.
Fox CS, Pencina MJ, Heard-Costa NL, Shrader P, Jaquish C, O’Donnell CJ, et al. Trends in the association of parental history of obesity over 60 years. Obesity (Silver Spring). 2014 Mar;22(3):919–24.
Fox, Caroline S., et al. “Trends in the association of parental history of obesity over 60 years.Obesity (Silver Spring), vol. 22, no. 3, Mar. 2014, pp. 919–24. Pubmed, doi:10.1002/oby.20564.
Fox CS, Pencina MJ, Heard-Costa NL, Shrader P, Jaquish C, O’Donnell CJ, Vasan RS, Cupples LA, D’Agostino RB. Trends in the association of parental history of obesity over 60 years. Obesity (Silver Spring). 2014 Mar;22(3):919–924.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

EISSN

1930-739X

Publication Date

March 2014

Volume

22

Issue

3

Start / End Page

919 / 924

Location

United States

Related Subject Headings

  • Weight Gain
  • United States
  • Risk Factors
  • Prevalence
  • Parents
  • Obesity
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans