Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.
Publication
, Journal Article
Carr, G; Derbyshire, ER; Caldera, E; Currie, CR; Clardy, J
Published in: Journal of natural products
October 2012
Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.
Duke Scholars
Published In
Journal of natural products
DOI
EISSN
1520-6025
ISSN
0163-3864
Publication Date
October 2012
Volume
75
Issue
10
Start / End Page
1806 / 1809
Related Subject Headings
- Symbiosis
- Sporozoites
- Saccharomyces cerevisiae
- Plasmodium berghei
- Microbial Sensitivity Tests
- Medicinal & Biomolecular Chemistry
- Liver
- Humans
- Hep G2 Cells
- Escherichia coli
Citation
APA
Chicago
ICMJE
MLA
NLM
Carr, G., Derbyshire, E. R., Caldera, E., Currie, C. R., & Clardy, J. (2012). Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of Natural Products, 75(10), 1806–1809. https://doi.org/10.1021/np300380t
Carr, Gavin, Emily R. Derbyshire, Eric Caldera, Cameron R. Currie, and Jon Clardy. “Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.” Journal of Natural Products 75, no. 10 (October 2012): 1806–9. https://doi.org/10.1021/np300380t.
Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of natural products. 2012 Oct;75(10):1806–9.
Carr, Gavin, et al. “Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.” Journal of Natural Products, vol. 75, no. 10, Oct. 2012, pp. 1806–09. Epmc, doi:10.1021/np300380t.
Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy J. Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. Journal of natural products. 2012 Oct;75(10):1806–1809.
Published In
Journal of natural products
DOI
EISSN
1520-6025
ISSN
0163-3864
Publication Date
October 2012
Volume
75
Issue
10
Start / End Page
1806 / 1809
Related Subject Headings
- Symbiosis
- Sporozoites
- Saccharomyces cerevisiae
- Plasmodium berghei
- Microbial Sensitivity Tests
- Medicinal & Biomolecular Chemistry
- Liver
- Humans
- Hep G2 Cells
- Escherichia coli