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Complex relationships of nicotinic receptor actions and cognitive functions.

Publication ,  Journal Article
Levin, ED
Published in: Biochem Pharmacol
October 15, 2013

Nicotine has been shown in a variety of studies to improve cognitive function including learning, memory and attention. Nicotine both stimulates and desensitizes nicotinic receptors, thus acting both as an agonist and a net antagonist. The relative roles of these two actions for nicotine-induced cognitive improvement have not yet been fully determined. We and others have found that acute nicotinic antagonist treatment can improve learning and attention. Nicotine acts on a variety of nicotinic receptor subtypes. The relative role and interactions of neuronal nicotinic receptor subtypes for cognition also needs to be better characterized. Nicotine acts on nicotinic receptors in a wide variety of brain areas. The role of some of these areas such as the hippocampus has been relatively well studied but other areas like the thalamus, which has the densest nicotinic receptor concentration are still only partially characterized. In a series of studies we characterized nicotinic receptor actions, anatomic localization and circuit interactions, which are critical to nicotine effects on the cognitive functions of learning, memory and attention. The relative role of increases and decreases in nicotinic receptor activation by nicotine were determined in regionally specific studies of the hippocampus, the amygdala, the frontal cortex and the mediodorsal thalamic nucleus with local infusions of antagonists of nicotinic receptor subtypes (α7 and α4β2). The understanding of the functional neural bases of cognitive function is fundamental to the more effective development of nicotinic drugs for treating cognitive dysfunction.

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Published In

Biochem Pharmacol

DOI

EISSN

1873-2968

Publication Date

October 15, 2013

Volume

86

Issue

8

Start / End Page

1145 / 1152

Location

England

Related Subject Headings

  • Receptors, Nicotinic
  • Pharmacology & Pharmacy
  • Humans
  • Gene Expression Regulation
  • Cognition Disorders
  • Cognition
  • Cholinergic Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3101 Biochemistry and cell biology
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Levin, E. D. (2013). Complex relationships of nicotinic receptor actions and cognitive functions. Biochem Pharmacol, 86(8), 1145–1152. https://doi.org/10.1016/j.bcp.2013.07.021
Levin, Edward D. “Complex relationships of nicotinic receptor actions and cognitive functions.Biochem Pharmacol 86, no. 8 (October 15, 2013): 1145–52. https://doi.org/10.1016/j.bcp.2013.07.021.
Levin ED. Complex relationships of nicotinic receptor actions and cognitive functions. Biochem Pharmacol. 2013 Oct 15;86(8):1145–52.
Levin, Edward D. “Complex relationships of nicotinic receptor actions and cognitive functions.Biochem Pharmacol, vol. 86, no. 8, Oct. 2013, pp. 1145–52. Pubmed, doi:10.1016/j.bcp.2013.07.021.
Levin ED. Complex relationships of nicotinic receptor actions and cognitive functions. Biochem Pharmacol. 2013 Oct 15;86(8):1145–1152.
Journal cover image

Published In

Biochem Pharmacol

DOI

EISSN

1873-2968

Publication Date

October 15, 2013

Volume

86

Issue

8

Start / End Page

1145 / 1152

Location

England

Related Subject Headings

  • Receptors, Nicotinic
  • Pharmacology & Pharmacy
  • Humans
  • Gene Expression Regulation
  • Cognition Disorders
  • Cognition
  • Cholinergic Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3101 Biochemistry and cell biology
  • 1115 Pharmacology and Pharmaceutical Sciences