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Mitochondria as a target of environmental toxicants

Publication ,  Journal Article
Meyer, JN; Leung, MCK; Rooney, JP; Sendoel, A; Hengartner, MO; Kisby, GE; Bess, AS
Published in: Toxicological Sciences
2013

Enormous strides have recently been made in our understanding of the biology and pathobiology of mitochondria. Many diseases have been identified as caused by mitochondrial dysfunction, and many pharmaceuticals have been identified as previously unrecognized mitochondrial toxicants. A much smaller but growing literature indicates that mitochondria are also targeted by environmental pollutants. We briefly review the importance of mitochondrial function and maintenance for health based on the genetics of mitochondrial diseases and the toxicities resulting from pharmaceutical exposure. We then discuss how the principles of mitochondrial vulnerability illustrated by those fields might apply to environmental contaminants, with particular attention to factors that may modulate vulnerability including genetic differences, epigenetic interactions, tissue characteristics, and developmental stage. Finally, we review the literature related to environmental mitochondrial toxicants, with a particular focus on those toxicants that target mitochondrial DNA. We conclude that the fields of environmental toxicology and environmental health should focus more strongly on mitochondria. © The Author 2013.

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Published In

Toxicological Sciences

DOI

ISSN

1096-6080

Publication Date

2013

Volume

134

Issue

1

Start / End Page

1 / 17

Related Subject Headings

  • Toxicology
  • Mutagens
  • Mitochondrial Diseases
  • Mitochondria
  • Humans
  • Environmental Pollutants
  • DNA, Mitochondrial
  • DNA Damage
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Meyer, J. N., Leung, M. C. K., Rooney, J. P., Sendoel, A., Hengartner, M. O., Kisby, G. E., & Bess, A. S. (2013). Mitochondria as a target of environmental toxicants. Toxicological Sciences, 134(1), 1–17. https://doi.org/10.1093/toxsci/kft102
Meyer, J. N., M. C. K. Leung, J. P. Rooney, A. Sendoel, M. O. Hengartner, G. E. Kisby, and A. S. Bess. “Mitochondria as a target of environmental toxicants.” Toxicological Sciences 134, no. 1 (2013): 1–17. https://doi.org/10.1093/toxsci/kft102.
Meyer JN, Leung MCK, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, et al. Mitochondria as a target of environmental toxicants. Toxicological Sciences. 2013;134(1):1–17.
Meyer, J. N., et al. “Mitochondria as a target of environmental toxicants.” Toxicological Sciences, vol. 134, no. 1, 2013, pp. 1–17. Scival, doi:10.1093/toxsci/kft102.
Meyer JN, Leung MCK, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, Bess AS. Mitochondria as a target of environmental toxicants. Toxicological Sciences. 2013;134(1):1–17.

Published In

Toxicological Sciences

DOI

ISSN

1096-6080

Publication Date

2013

Volume

134

Issue

1

Start / End Page

1 / 17

Related Subject Headings

  • Toxicology
  • Mutagens
  • Mitochondrial Diseases
  • Mitochondria
  • Humans
  • Environmental Pollutants
  • DNA, Mitochondrial
  • DNA Damage
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences