Understanding and targeting resistance to anti-angiogenic therapies.
Publication
, Journal Article
Clarke, JM; Hurwitz, HI
Published in: J Gastrointest Oncol
September 2013
Therapies targeting tumor angiogenesis are used in a variety of malignancies, however not all patients benefit from treatment and impact on tumor control may be transient and modest. Mechanisms of resistance to anti-angiogenic therapies can be broadly categorized into VEGF-axis dependent alterations, non-VEGF pathways, and stromal cell interactions. Complimentary combinations of agents that inhibit alternative mechanisms of blood vessel formation may optimize inhibition of angiogenesis and improve clinical benefit for patients. The purpose of this review is to detail the preclinical evidence for mechanisms of angiogenic resistance and provide an overview of novel therapeutic approaches exploiting these pathways.
Duke Scholars
Published In
J Gastrointest Oncol
DOI
ISSN
2078-6891
Publication Date
September 2013
Volume
4
Issue
3
Start / End Page
253 / 263
Location
China
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Clarke, J. M., & Hurwitz, H. I. (2013). Understanding and targeting resistance to anti-angiogenic therapies. J Gastrointest Oncol, 4(3), 253–263. https://doi.org/10.3978/j.issn.2078-6891.2013.036
Clarke, Jeffrey M., and Herbert I. Hurwitz. “Understanding and targeting resistance to anti-angiogenic therapies.” J Gastrointest Oncol 4, no. 3 (September 2013): 253–63. https://doi.org/10.3978/j.issn.2078-6891.2013.036.
Clarke JM, Hurwitz HI. Understanding and targeting resistance to anti-angiogenic therapies. J Gastrointest Oncol. 2013 Sep;4(3):253–63.
Clarke, Jeffrey M., and Herbert I. Hurwitz. “Understanding and targeting resistance to anti-angiogenic therapies.” J Gastrointest Oncol, vol. 4, no. 3, Sept. 2013, pp. 253–63. Pubmed, doi:10.3978/j.issn.2078-6891.2013.036.
Clarke JM, Hurwitz HI. Understanding and targeting resistance to anti-angiogenic therapies. J Gastrointest Oncol. 2013 Sep;4(3):253–263.
Published In
J Gastrointest Oncol
DOI
ISSN
2078-6891
Publication Date
September 2013
Volume
4
Issue
3
Start / End Page
253 / 263
Location
China
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences