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Protecting the hedgerow: p53 and hedgehog pathway interactions.

Publication ,  Journal Article
Ho, L; Alman, B
Published in: Cell Cycle
February 1, 2010

A common environment for the Hedgehog (Subfamily: erinaceinae) is a row of shrubs and trees often used on farms for enclosing or separating fields, called a hedgerow. Maintenance of a continuous shrub border is important for shielding crops from weather damage, but also provides an ideal protective habitat for the hedgehog. Similar to its mammalian counterpart, the Hedgehog (Hh) signalling pathway requires a controlled environment to regulate proper functioning of the cell. When allowed to run wild, constitutive activation of the Hh pathway results in tumorigenesis in different tissues types, including brain, skin and cartilage. With an additional loss of p53 tumor suppressor activity, an increase in tumor incidence, size and metastasis have been observed. p53 has a number of functions that can suppress tumor formation and growth in most, if not all Hh-related cancers, such as the inhibition of cell cycle progression and cell survival. Furthermore, increasing evidence of an interaction between p53 and Hedgehog signalling pathways suggests a critical role for the tumor suppressor activity of p53 in "protecting the hedgerow".

Duke Scholars

Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

February 1, 2010

Volume

9

Issue

3

Start / End Page

506 / 511

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Protein Binding
  • Neoplasms
  • Humans
  • Hedgehog Proteins
  • Evolution, Molecular
  • Developmental Biology
  • Animals
  • 3101 Biochemistry and cell biology
 

Citation

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Ho, L., & Alman, B. (2010). Protecting the hedgerow: p53 and hedgehog pathway interactions. Cell Cycle, 9(3), 506–511. https://doi.org/10.4161/cc.9.3.10552
Ho, Louisa, and Benjamin Alman. “Protecting the hedgerow: p53 and hedgehog pathway interactions.Cell Cycle 9, no. 3 (February 1, 2010): 506–11. https://doi.org/10.4161/cc.9.3.10552.
Ho L, Alman B. Protecting the hedgerow: p53 and hedgehog pathway interactions. Cell Cycle. 2010 Feb 1;9(3):506–11.
Ho, Louisa, and Benjamin Alman. “Protecting the hedgerow: p53 and hedgehog pathway interactions.Cell Cycle, vol. 9, no. 3, Feb. 2010, pp. 506–11. Pubmed, doi:10.4161/cc.9.3.10552.
Ho L, Alman B. Protecting the hedgerow: p53 and hedgehog pathway interactions. Cell Cycle. 2010 Feb 1;9(3):506–511.

Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

February 1, 2010

Volume

9

Issue

3

Start / End Page

506 / 511

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Protein Binding
  • Neoplasms
  • Humans
  • Hedgehog Proteins
  • Evolution, Molecular
  • Developmental Biology
  • Animals
  • 3101 Biochemistry and cell biology