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First successful lower-extremity transplantation: technique and functional result.

Publication ,  Journal Article
Zuker, RM; Redett, R; Alman, B; Coles, JG; Timoney, N; Ein, SH
Published in: J Reconstr Microsurg
May 2006

Composite tissue transplantation has emerged as a viable alternative to prosthetics and complex reconstructive surgery. Thus far it is reserved for cases which cannot be effectively reconstructed and where it offers some benefits over prostheses. It has been used in the upper extremity with encouraging results and, most recently, in the face. This report outlines what is believed to be the first such use in the lower extremity. A normal lower limb in a 3-month-old ischiopagus twin who was not going to survive was transplanted to the appropriate pelvic position, revascularized, and reinnervated in an otherwise healthy sister. The limb survived and, because of the immune compatibility, did not require immune suppressive therapy. The return of muscle function in the transplanted limb is encouraging. The transplanted limb appears to be fully sensate. In addition to reinnervation, the limb is now spontaneously under the cortical control of the recipient.

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Published In

J Reconstr Microsurg

DOI

ISSN

0743-684X

Publication Date

May 2006

Volume

22

Issue

4

Start / End Page

239 / 244

Location

United States

Related Subject Headings

  • Twins, Conjoined
  • Treatment Outcome
  • Surgical Flaps
  • Surgery
  • Skin Transplantation
  • Sciatic Nerve
  • Plastic Surgery Procedures
  • Patient Care Planning
  • Osteotomy
  • Muscle, Skeletal
 

Citation

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Zuker, R. M., Redett, R., Alman, B., Coles, J. G., Timoney, N., & Ein, S. H. (2006). First successful lower-extremity transplantation: technique and functional result. J Reconstr Microsurg, 22(4), 239–244. https://doi.org/10.1055/s-2006-939928
Zuker, Ronald M., Rick Redett, Ben Alman, John G. Coles, Norma Timoney, and Sigmund H. Ein. “First successful lower-extremity transplantation: technique and functional result.J Reconstr Microsurg 22, no. 4 (May 2006): 239–44. https://doi.org/10.1055/s-2006-939928.
Zuker RM, Redett R, Alman B, Coles JG, Timoney N, Ein SH. First successful lower-extremity transplantation: technique and functional result. J Reconstr Microsurg. 2006 May;22(4):239–44.
Zuker, Ronald M., et al. “First successful lower-extremity transplantation: technique and functional result.J Reconstr Microsurg, vol. 22, no. 4, May 2006, pp. 239–44. Pubmed, doi:10.1055/s-2006-939928.
Zuker RM, Redett R, Alman B, Coles JG, Timoney N, Ein SH. First successful lower-extremity transplantation: technique and functional result. J Reconstr Microsurg. 2006 May;22(4):239–244.
Journal cover image

Published In

J Reconstr Microsurg

DOI

ISSN

0743-684X

Publication Date

May 2006

Volume

22

Issue

4

Start / End Page

239 / 244

Location

United States

Related Subject Headings

  • Twins, Conjoined
  • Treatment Outcome
  • Surgical Flaps
  • Surgery
  • Skin Transplantation
  • Sciatic Nerve
  • Plastic Surgery Procedures
  • Patient Care Planning
  • Osteotomy
  • Muscle, Skeletal