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Fracture failure mechanisms in patients with osteogenesis imperfecta.

Publication ,  Journal Article
Alman, B; Frasca, P
Published in: J Orthop Res
1987

This investigation examines the failure mechanism of bone from patients with osteogenesis imperfecta (OI). Mechanical testing and ultrastructural analysis of surgically obtained bone specimens, from patients with OI and from approximately age matched normal controls, were performed. Small rectangular bone samples (1.0 mm X 1.2 mm X 15 mm) with a prismatic cross section were put under three-point bending to determine the work to fracture. Furthermore, the fracture surface was observed with scanning electron microscopy (SEM). The SEM observation of partially dissected lamellae was also performed to determine the collagen organization of the bone. The OI bone has a consistently lower work to fracture and reduced collagen organization than the normal controls. The fracture surface of the OI bone is rough and exhibits a "pull-out" type of morphology, as opposed to the smoother fracture surface of the controls. This study shows that a relatively simple mechanical test utilizing a small amount of bone can differentiate between a diseased state (OI) and a normal state of bone.

Duke Scholars

Published In

J Orthop Res

DOI

ISSN

0736-0266

Publication Date

1987

Volume

5

Issue

1

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Osteogenesis Imperfecta
  • Orthopedics
  • Microscopy, Electron, Scanning
  • Humans
  • Fractures, Spontaneous
  • Bone and Bones
  • Biomechanical Phenomena
  • 4207 Sports science and exercise
  • 4003 Biomedical engineering
  • 1106 Human Movement and Sports Sciences
 

Citation

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Alman, B., & Frasca, P. (1987). Fracture failure mechanisms in patients with osteogenesis imperfecta. J Orthop Res, 5(1), 139–143. https://doi.org/10.1002/jor.1100050118
Alman, B., and P. Frasca. “Fracture failure mechanisms in patients with osteogenesis imperfecta.J Orthop Res 5, no. 1 (1987): 139–43. https://doi.org/10.1002/jor.1100050118.
Alman B, Frasca P. Fracture failure mechanisms in patients with osteogenesis imperfecta. J Orthop Res. 1987;5(1):139–43.
Alman, B., and P. Frasca. “Fracture failure mechanisms in patients with osteogenesis imperfecta.J Orthop Res, vol. 5, no. 1, 1987, pp. 139–43. Pubmed, doi:10.1002/jor.1100050118.
Alman B, Frasca P. Fracture failure mechanisms in patients with osteogenesis imperfecta. J Orthop Res. 1987;5(1):139–143.
Journal cover image

Published In

J Orthop Res

DOI

ISSN

0736-0266

Publication Date

1987

Volume

5

Issue

1

Start / End Page

139 / 143

Location

United States

Related Subject Headings

  • Osteogenesis Imperfecta
  • Orthopedics
  • Microscopy, Electron, Scanning
  • Humans
  • Fractures, Spontaneous
  • Bone and Bones
  • Biomechanical Phenomena
  • 4207 Sports science and exercise
  • 4003 Biomedical engineering
  • 1106 Human Movement and Sports Sciences