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Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation.

Publication ,  Journal Article
Sinner, MF; Wang, N; Fox, CS; Fontes, JD; Rienstra, M; Magnani, JW; Vasan, RS; Calderwood, AH; Pencina, M; Sullivan, LM; Ellinor, PT; Benjamin, EJ
Published in: Am J Cardiol
January 15, 2013

Heart failure, a strong risk factor for atrial fibrillation (AF), is often accompanied by elevated liver transaminases. The aim of this study was to test the hypothesis that elevated transaminases are associated with the risk for incident AF in the community. A total of 3,744 participants (mean age 65 ± 10 years, 56.8% women) from the Framingham Heart Study Original and Offspring cohorts, free of clinical heart failure, were studied. Cox proportional-hazards models adjusted for standard AF risk factors (age, gender, body mass index, systolic blood pressure, electrocardiographic PR interval, antihypertensive treatment, smoking, diabetes, valvular heart disease, and alcohol consumption) were examined to investigate associations between baseline serum transaminase levels (alanine transaminase and aspartate transaminase) and the incidence of AF over up to 10 years (29,099 person-years) of follow-up. During follow-up, 383 subjects developed AF. The 2 transaminases were significantly associated with greater risk for incident AF (hazard ratio expressed per SD of natural logarithmically transformed biomarker: alanine transaminase hazard ratio 1.19, 95% confidence interval 1.07 to 1.32, p = 0.002; aspartate transaminase hazard ratio 1.12, 95% confidence interval 1.01 to 1.24, p = 0.03). The associations between transaminases and AF remained consistent after the exclusion of participants with moderate to severe alcohol consumption. However, when added to known risk factors for AF, alanine transaminase and aspartate transaminase only subtly improved the prediction of AF. In conclusion, elevated transaminase concentrations are associated with increased AF incidence. The mechanisms by which higher mean transaminase concentrations are associated with incident AF remain to be determined.

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Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

January 15, 2013

Volume

111

Issue

2

Start / End Page

219 / 224

Location

United States

Related Subject Headings

  • Transaminases
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Proportional Hazards Models
  • Massachusetts
  • Male
  • Liver
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
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Sinner, M. F., Wang, N., Fox, C. S., Fontes, J. D., Rienstra, M., Magnani, J. W., … Benjamin, E. J. (2013). Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation. Am J Cardiol, 111(2), 219–224. https://doi.org/10.1016/j.amjcard.2012.09.021
Sinner, Moritz F., Na Wang, Caroline S. Fox, João D. Fontes, Michiel Rienstra, Jared W. Magnani, Ramachandran S. Vasan, et al. “Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation.Am J Cardiol 111, no. 2 (January 15, 2013): 219–24. https://doi.org/10.1016/j.amjcard.2012.09.021.
Sinner MF, Wang N, Fox CS, Fontes JD, Rienstra M, Magnani JW, et al. Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation. Am J Cardiol. 2013 Jan 15;111(2):219–24.
Sinner, Moritz F., et al. “Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation.Am J Cardiol, vol. 111, no. 2, Jan. 2013, pp. 219–24. Pubmed, doi:10.1016/j.amjcard.2012.09.021.
Sinner MF, Wang N, Fox CS, Fontes JD, Rienstra M, Magnani JW, Vasan RS, Calderwood AH, Pencina M, Sullivan LM, Ellinor PT, Benjamin EJ. Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation. Am J Cardiol. 2013 Jan 15;111(2):219–224.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

January 15, 2013

Volume

111

Issue

2

Start / End Page

219 / 224

Location

United States

Related Subject Headings

  • Transaminases
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Proportional Hazards Models
  • Massachusetts
  • Male
  • Liver
  • Incidence