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Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention.

Publication ,  Journal Article
Fatemi, O; Paranilam, J; Rainow, A; Kennedy, K; Choi, J; Cutlip, D; Pencina, M; Berger, PB; Cohen, DJ; Kleiman, NS
Published in: J Thromb Thrombolysis
January 2013

Red cell distribution width (RDW), a measure of the variability in size of circulating erythrocytes, is an independent predictor of mortality in patients with cardiovascular disease. We hypothesized that RDW is a prognostic marker of death, myocardial infarction and unplanned revascularization in a broad population undergoing percutaneous coronary intervention (PCI). We investigated the prognostic value of RDW derived from a complete blood count drawn ≤24 h of PCI in 1,689 patients at four centers who underwent PCI between 2004 and 2007 in the evaluation of drug eluting stents and ischemic events registry. Patients who underwent blood transfusions were excluded. Multivariable analyses of death, MI, unplanned revascularization, and the combined occurrence of these events at 1 year were performed using methods from survival analysis. The analysis was adjusted for creatinine ≥1.5 mg/dL, hemoglobin, congestive heart failure, coronary artery bypass grafting history, male sex, BMI, atherosclerosis of ≥2 coronary vessels, and hypertension. In univariate analysis of RDW stratified by quartiles, membership in the highest quartile was a predictor of mortality as compared to the lowest quartile (HR 5.07, CI 2.07-12.40, p < 0.001). In multivariate analysis, RDW was not an independent predictor of unplanned revascularization after PCI; however, RDW remained an independent correlate of 1 year mortality (HR 1.65, CI 1.22-2.23, p = 0.001); with a continuous net reclassification improvement of 46.5% (95% CI 15.1-76.4%) and a relative integrated discrimination improvement of 57.8% (95% CI 22.1-94.9%) after PCI. RDW is a widely available independent correlate of 1-year mortality after PCI that increases the discriminative value of risk prediction in these patients.

Duke Scholars

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

January 2013

Volume

35

Issue

1

Start / End Page

57 / 64

Location

Netherlands

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Predictive Value of Tests
  • Percutaneous Coronary Intervention
  • Middle Aged
  • Male
  • Humans
  • Hemoglobins
  • Heart Failure
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Fatemi, O., Paranilam, J., Rainow, A., Kennedy, K., Choi, J., Cutlip, D., … Kleiman, N. S. (2013). Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention. J Thromb Thrombolysis, 35(1), 57–64. https://doi.org/10.1007/s11239-012-0767-x
Fatemi, Omid, Jaya Paranilam, Alex Rainow, Kevin Kennedy, Jason Choi, Donald Cutlip, Michael Pencina, Peter B. Berger, David J. Cohen, and Neal S. Kleiman. “Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention.J Thromb Thrombolysis 35, no. 1 (January 2013): 57–64. https://doi.org/10.1007/s11239-012-0767-x.
Fatemi O, Paranilam J, Rainow A, Kennedy K, Choi J, Cutlip D, et al. Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention. J Thromb Thrombolysis. 2013 Jan;35(1):57–64.
Fatemi, Omid, et al. “Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention.J Thromb Thrombolysis, vol. 35, no. 1, Jan. 2013, pp. 57–64. Pubmed, doi:10.1007/s11239-012-0767-x.
Fatemi O, Paranilam J, Rainow A, Kennedy K, Choi J, Cutlip D, Pencina M, Berger PB, Cohen DJ, Kleiman NS. Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention. J Thromb Thrombolysis. 2013 Jan;35(1):57–64.
Journal cover image

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

January 2013

Volume

35

Issue

1

Start / End Page

57 / 64

Location

Netherlands

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Predictive Value of Tests
  • Percutaneous Coronary Intervention
  • Middle Aged
  • Male
  • Humans
  • Hemoglobins
  • Heart Failure
  • Follow-Up Studies