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Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure.

Publication ,  Journal Article
Novack, V; Pencina, M; Zahger, D; Fuchs, L; Nevzorov, R; Jotkowitz, A; Porath, A
Published in: PLoS One
August 17, 2010

INTRODUCTION: Several blood tests are performed uniformly in patients hospitalized with acute decompensated heart failure and are predictive of the outcomes: complete blood count, electrolytes, renal function, glucose, albumin and uric acid. We sought to evaluate the relationship between routine admission laboratory tests results, patient characteristics and 30-day and one-year mortality of patients admitted for decompensated heart failure and to construct a simple mortality prediction tool. METHODS: A retrospective population based study. Data from seven tertiary hospitals on all admissions with a principal diagnosis of heart failure during the years 2002-2005 throughout Israel were captured. RESULTS: 8,246 patients were included in the study cohort. Thirty day mortality rate was 8.5% (701 patients) and one-year mortality rate was 28.7% (2,365 patients). Addition of five routine laboratory tests results (albumin, sodium, blood urea, uric acid and WBC) to a set of clinical and demographic characteristics improved c-statistics from 0.76 to 0.81 for 30-days and from 0.72 to 0.76 for one-year mortality prediction (both p-values <0.0001). Three dichotomized abnormal laboratory results with highest odds ratio for one-year mortality (hypoalbuminaemia, hyponatremia and elevated blood urea) were used to construct a simple prediction score, capable of discriminating from 1.1% to 21.4% in 30-day and from 11.6% to 55.6% in one-year mortality rates between patients with a score of 0 (1,477 patients) vs. score of 3 (544 patients). DISCUSSION: A small set of abnormal routine laboratory results upon admission can risk-stratify and independently predict 30-day and one-year mortality in patients hospitalized with acute decompensated heart failure.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

August 17, 2010

Volume

5

Issue

8

Start / End Page

e12184

Location

United States

Related Subject Headings

  • Time Factors
  • Risk
  • Retrospective Studies
  • Reproducibility of Results
  • Prognosis
  • Multivariate Analysis
  • Male
  • Humans
  • Hospitalization
  • Heart Failure
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Novack, V., Pencina, M., Zahger, D., Fuchs, L., Nevzorov, R., Jotkowitz, A., & Porath, A. (2010). Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure. PLoS One, 5(8), e12184. https://doi.org/10.1371/journal.pone.0012184
Novack, Victor, Michael Pencina, Doron Zahger, Lior Fuchs, Roman Nevzorov, Allan Jotkowitz, and Avi Porath. “Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure.PLoS One 5, no. 8 (August 17, 2010): e12184. https://doi.org/10.1371/journal.pone.0012184.
Novack V, Pencina M, Zahger D, Fuchs L, Nevzorov R, Jotkowitz A, et al. Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure. PLoS One. 2010 Aug 17;5(8):e12184.
Novack, Victor, et al. “Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure.PLoS One, vol. 5, no. 8, Aug. 2010, p. e12184. Pubmed, doi:10.1371/journal.pone.0012184.
Novack V, Pencina M, Zahger D, Fuchs L, Nevzorov R, Jotkowitz A, Porath A. Routine laboratory results and thirty day and one-year mortality risk following hospitalization with acute decompensated heart failure. PLoS One. 2010 Aug 17;5(8):e12184.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

August 17, 2010

Volume

5

Issue

8

Start / End Page

e12184

Location

United States

Related Subject Headings

  • Time Factors
  • Risk
  • Retrospective Studies
  • Reproducibility of Results
  • Prognosis
  • Multivariate Analysis
  • Male
  • Humans
  • Hospitalization
  • Heart Failure