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Multivessel drug-eluting stenting and impact of diabetes mellitus--a report from the EVENT registry.

Publication ,  Journal Article
Novack, V; Tsyvine, D; Cohen, DJ; Pencina, M; Dubin, J; Dehghani, H; Kleiman, NS; Cutlip, DE
Published in: Catheter Cardiovasc Interv
June 1, 2009

OBJECTIVES: To compare clinical outcomes in patients with and without diabetes after multivessel percutaneous coronary intervention (PCI). BACKGROUND: Diabetes is associated with significantly worse outcomes after multivessel PCI and coronary bypass surgery is recommended as the preferred option for these patients. METHODS AND RESULTS: The Evaluation of Drug Eluting Stents and Ischemic Events registry is a multicenter evaluation of acute and 1 year outcomes in unselected patients undergoing PCI since approval of drug-eluting stents (DES). Major adverse cardiac events (MACE) were defined as all cause mortality, myocardial infarction, or repeat revascularization and rate was estimated by Kaplan-Meier method and compared using log-rank. The independent correlates of MACE were determined using Cox proportional hazards regression. Of 4,819 nonemergency native coronary DES procedures, 1,595 (33.1%) were in patients with diabetes and 722 (11.7%) involved >1 vessel. Of patients undergoing multivessel procedures, diabetes was present in 256 (35.5%). One year after multivessel PCI, MACE was similar for patients with or without diabetes (22.3% versus 21.2%, log-rank test P = 0.85). The independent correlates of 1 year MACE were female sex (Hazard ratio [HR], 1.58, 95% CI 1.14-2.20), ejection fraction (HR 0.74 per group [<25%, 26-35%, 36-50%, and >50%], 95%CI 0.59-0.94) and number of stents (HR 1.20 per stent, 95%CI 1.04-1.38) but not diabetes (HR 1.00, 95% CI 0.71-1.39). CONCLUSIONS: Multivessel DES is performed commonly in patients with diabetes with outcomes at 1 year similar to patients without diabetes. Longer follow-up is required to more fully evaluate the safety and effectiveness of this strategy.

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Published In

Catheter Cardiovasc Interv

DOI

EISSN

1522-726X

Publication Date

June 1, 2009

Volume

73

Issue

7

Start / End Page

874 / 880

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Registries
  • Prospective Studies
  • Proportional Hazards Models
  • Myocardial Infarction
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Novack, V., Tsyvine, D., Cohen, D. J., Pencina, M., Dubin, J., Dehghani, H., … Cutlip, D. E. (2009). Multivessel drug-eluting stenting and impact of diabetes mellitus--a report from the EVENT registry. Catheter Cardiovasc Interv, 73(7), 874–880. https://doi.org/10.1002/ccd.21925
Novack, Victor, Daniel Tsyvine, David J. Cohen, Michael Pencina, Joseph Dubin, Hossein Dehghani, Neal S. Kleiman, and Donald E. Cutlip. “Multivessel drug-eluting stenting and impact of diabetes mellitus--a report from the EVENT registry.Catheter Cardiovasc Interv 73, no. 7 (June 1, 2009): 874–80. https://doi.org/10.1002/ccd.21925.
Novack V, Tsyvine D, Cohen DJ, Pencina M, Dubin J, Dehghani H, et al. Multivessel drug-eluting stenting and impact of diabetes mellitus--a report from the EVENT registry. Catheter Cardiovasc Interv. 2009 Jun 1;73(7):874–80.
Novack, Victor, et al. “Multivessel drug-eluting stenting and impact of diabetes mellitus--a report from the EVENT registry.Catheter Cardiovasc Interv, vol. 73, no. 7, June 2009, pp. 874–80. Pubmed, doi:10.1002/ccd.21925.
Novack V, Tsyvine D, Cohen DJ, Pencina M, Dubin J, Dehghani H, Kleiman NS, Cutlip DE. Multivessel drug-eluting stenting and impact of diabetes mellitus--a report from the EVENT registry. Catheter Cardiovasc Interv. 2009 Jun 1;73(7):874–880.
Journal cover image

Published In

Catheter Cardiovasc Interv

DOI

EISSN

1522-726X

Publication Date

June 1, 2009

Volume

73

Issue

7

Start / End Page

874 / 880

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Registries
  • Prospective Studies
  • Proportional Hazards Models
  • Myocardial Infarction
  • Middle Aged