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C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study.

Publication ,  Journal Article
Wilson, PWF; Nam, B-H; Pencina, M; D'Agostino, RB; Benjamin, EJ; O'Donnell, CJ
Published in: Arch Intern Med
November 28, 2005

BACKGROUND: Determination of C-reactive protein (CRP) level has been suggested to improve cardiovascular disease (CVD) risk assessment. This study examines the utility of CRP levels to assess CVD risk in a community setting. METHODS: We performed a prospective observational cohort study on a community population sample. A total of 1949 men and 2497 women without CVD from the Framingham Heart Study underwent CVD risk factor assessment. Initial CVD events during 8 years of follow-up were recorded. RESULTS: There were 283 major CVD and 160 major coronary heart disease incident events. Age-, sex-, and multivariable-adjusted analyses generally used CRP level categories of less than 1, 1 to 3, and greater than 3 mg/L. In age- and sex-adjusted models, the traditional risk factors and elevated CRP levels indicated increased risk. The age- and sex-adjusted relative risk (RR) and 95% confidence interval (CI) of CRP level greater than 3 mg/L for major CVD was elevated (RR, 1.60; 95% CI, 1.19-2.14), with evidence of attenuation (RR, 1.22; 95% CI, 0.90-1.66) in multivariable models. The C statistic, a measure of the discriminatory capability of the prediction models, was 0.74 for prediction of major CVD with age and CRP level. In multivariable models that included traditional risk factors, the C statistic was 0.78, a value that was unchanged with the addition of CRP to the multivariable model. Similar relations were noted for major coronary heart disease events. CONCLUSION: Elevated CRP level provided no further prognostic information beyond traditional office risk factor assessment to predict future major CVD and major coronary heart disease in this population sample.

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Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

November 28, 2005

Volume

165

Issue

21

Start / End Page

2473 / 2478

Location

United States

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Prevalence
  • Population Surveillance
  • Observation
  • Middle Aged
  • Male
  • Humans
  • General & Internal Medicine
 

Citation

APA
Chicago
ICMJE
MLA
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Wilson, P. W. F., Nam, B.-H., Pencina, M., D’Agostino, R. B., Benjamin, E. J., & O’Donnell, C. J. (2005). C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Arch Intern Med, 165(21), 2473–2478. https://doi.org/10.1001/archinte.165.21.2473
Wilson, Peter W. F., Byung-Ho Nam, Michael Pencina, Ralph B. D’Agostino, Emelia J. Benjamin, and Christopher J. O’Donnell. “C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study.Arch Intern Med 165, no. 21 (November 28, 2005): 2473–78. https://doi.org/10.1001/archinte.165.21.2473.
Wilson PWF, Nam B-H, Pencina M, D’Agostino RB, Benjamin EJ, O’Donnell CJ. C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Arch Intern Med. 2005 Nov 28;165(21):2473–8.
Wilson, Peter W. F., et al. “C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study.Arch Intern Med, vol. 165, no. 21, Nov. 2005, pp. 2473–78. Pubmed, doi:10.1001/archinte.165.21.2473.
Wilson PWF, Nam B-H, Pencina M, D’Agostino RB, Benjamin EJ, O’Donnell CJ. C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Arch Intern Med. 2005 Nov 28;165(21):2473–2478.

Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

November 28, 2005

Volume

165

Issue

21

Start / End Page

2473 / 2478

Location

United States

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Prevalence
  • Population Surveillance
  • Observation
  • Middle Aged
  • Male
  • Humans
  • General & Internal Medicine