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Ultra high-resolution anterior segment optical coherence tomography in the evaluation of anterior corneal dystrophies and degenerations.

Publication ,  Journal Article
Vajzovic, LM; Karp, CL; Haft, P; Shousha, MA; Dubovy, SR; Hurmeric, V; Yoo, SH; Wang, J
Published in: Ophthalmology
July 2011

PURPOSE: To evaluate the clinical usefulness of a spectral-domain ultra high-resolution anterior segment optical coherence tomography (UHR OCT) in examination, diagnosis, and management of various anterior corneal dystrophies and degenerations. DESIGN: Noncomparative case series. PARTICIPANTS: Fifty-nine eyes of 38 consecutive patients were enrolled in the study and included 28 eyes of 14 patients with anterior corneal dystrophies, 21 eyes of 19 patients with anterior corneal degenerations or neoplasia, and 10 eyes of 5 patients with normal corneas. METHODS: Subjects were imaged using a novel custom-built UHR OCT. Images were used to evaluate and describe the characteristics of anterior corneal dystrophies and degenerations. Nineteen patients underwent surgical management, and those histopathologic specimens were analyzed and correlated with the UHR OCT images. MAIN OUTCOME MEASURES: Comparison of clinical findings, UHR OCT images, and corresponding histopathologic specimens. RESULTS: The UHR OCT provided clear delineation of corneal anatomic features and pathologic corneal deposits in most cases. The characteristics and depth of these deposits are illustrated and can be localized to specific layers of the cornea. When available, there was significant correlation between UHR OCT images and histopathologic features, providing a noninvasive confirmation of the clinical diagnosis. CONCLUSIONS: Ultra high-resolution OCT is an innovative technique to perform in vivo optical biopsies and a promising research and clinical tool for the evaluation of corneal pathologic features in a noninvasive manner. The future use of this novel technology will evolve and increasingly is becoming a vital tool in the clinical and surgical management of corneal diseases.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

July 2011

Volume

118

Issue

7

Start / End Page

1291 / 1296

Location

United States

Related Subject Headings

  • Young Adult
  • Tomography, Optical Coherence
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Female
  • Corneal Diseases
  • Conjunctival Neoplasms
  • Carcinoma, Squamous Cell
 

Citation

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ICMJE
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Vajzovic, L. M., Karp, C. L., Haft, P., Shousha, M. A., Dubovy, S. R., Hurmeric, V., … Wang, J. (2011). Ultra high-resolution anterior segment optical coherence tomography in the evaluation of anterior corneal dystrophies and degenerations. Ophthalmology, 118(7), 1291–1296. https://doi.org/10.1016/j.ophtha.2010.12.015
Vajzovic, Lejla M., Carol L. Karp, Payman Haft, Mohamed Abou Shousha, Sander R. Dubovy, Volkan Hurmeric, Sonia H. Yoo, and Jianhua Wang. “Ultra high-resolution anterior segment optical coherence tomography in the evaluation of anterior corneal dystrophies and degenerations.Ophthalmology 118, no. 7 (July 2011): 1291–96. https://doi.org/10.1016/j.ophtha.2010.12.015.
Vajzovic LM, Karp CL, Haft P, Shousha MA, Dubovy SR, Hurmeric V, et al. Ultra high-resolution anterior segment optical coherence tomography in the evaluation of anterior corneal dystrophies and degenerations. Ophthalmology. 2011 Jul;118(7):1291–6.
Vajzovic, Lejla M., et al. “Ultra high-resolution anterior segment optical coherence tomography in the evaluation of anterior corneal dystrophies and degenerations.Ophthalmology, vol. 118, no. 7, July 2011, pp. 1291–96. Pubmed, doi:10.1016/j.ophtha.2010.12.015.
Vajzovic LM, Karp CL, Haft P, Shousha MA, Dubovy SR, Hurmeric V, Yoo SH, Wang J. Ultra high-resolution anterior segment optical coherence tomography in the evaluation of anterior corneal dystrophies and degenerations. Ophthalmology. 2011 Jul;118(7):1291–1296.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

July 2011

Volume

118

Issue

7

Start / End Page

1291 / 1296

Location

United States

Related Subject Headings

  • Young Adult
  • Tomography, Optical Coherence
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Female
  • Corneal Diseases
  • Conjunctival Neoplasms
  • Carcinoma, Squamous Cell