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NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS.

Publication ,  Journal Article
Chen, M; McDaniel, JR; Mackay, JA; Chilkoti, A
Published in: Technology and innovation
January 2011

Self-assemblies are complex structures spontaneously organized from simpler subcomponents, primarily through noncovalent interactions. These structures are being exploited as delivery vehicles of therapeutic and imaging agents. They have two unique advantages in comparison to other vehicles: 1) they are able to assume complex structures that are difficult to attain by chemical synthesis, and 2) the dissociation of self-assembled structures can be triggered by external stimuli, which can serve as a mechanism of payload release. In this review, we discuss two naturally occurring (proteins and viral capsids) and five engineered self-assemblies (vesicles, micelles, proteins, hydrogels, and inclusion complexes) that are under development for delivery of drugs and imaging agents. For each class of self-assembled supramolecular structures, we examine its structural and physicochemical properties, and potential applications within the context of assembly, loading, and payload release.

Duke Scholars

Published In

Technology and innovation

DOI

ISSN

1949-8241

Publication Date

January 2011

Volume

13

Issue

1

Start / End Page

5 / 25
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, M., McDaniel, J. R., Mackay, J. A., & Chilkoti, A. (2011). NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS. Technology and Innovation, 13(1), 5–25. https://doi.org/10.3727/194982411x13003853539948
Chen, Mingnan, Jonathan R. McDaniel, J Andrew Mackay, and Ashutosh Chilkoti. “NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS.Technology and Innovation 13, no. 1 (January 2011): 5–25. https://doi.org/10.3727/194982411x13003853539948.
Chen M, McDaniel JR, Mackay JA, Chilkoti A. NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS. Technology and innovation. 2011 Jan;13(1):5–25.
Chen, Mingnan, et al. “NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS.Technology and Innovation, vol. 13, no. 1, Jan. 2011, pp. 5–25. Epmc, doi:10.3727/194982411x13003853539948.
Chen M, McDaniel JR, Mackay JA, Chilkoti A. NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS. Technology and innovation. 2011 Jan;13(1):5–25.
Journal cover image

Published In

Technology and innovation

DOI

ISSN

1949-8241

Publication Date

January 2011

Volume

13

Issue

1

Start / End Page

5 / 25