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Hedgehog signaling requires motile cilia in the sea urchin.

Publication ,  Journal Article
Warner, JF; McCarthy, AM; Morris, RL; McClay, DR
Published in: Molecular biology and evolution
January 2014

A relatively small number of signaling pathways govern the early patterning processes of metazoan development. The architectural changes over time to these signaling pathways offer unique insights into their evolution. In the case of Hedgehog (Hh) signaling, two very divergent mechanisms of pathway transduction have evolved. In vertebrates, signaling relies on trafficking of Hh pathway components to nonmotile specialized primary cilia. In contrast, protostomes do not use cilia of any kind for Hh signal transduction. How these divergent lineages adapted such dramatically different ways of activating the signaling pathway is an unanswered question. Here, we present evidence that in the sea urchin, a basal deuterostome, motile cilia are required for embryonic Hh signal transduction, and the Hh receptor Smoothened (Smo) localizes to cilia during active Hh signaling. This is the first evidence that Hh signaling requires motile cilia and the first case of an organism requiring cilia outside of the vertebrate lineage.

Duke Scholars

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

January 2014

Volume

31

Issue

1

Start / End Page

18 / 22

Related Subject Headings

  • Signal Transduction
  • Sea Urchins
  • Receptors, G-Protein-Coupled
  • Microscopy, Electron, Scanning
  • Hedgehog Proteins
  • Evolutionary Biology
  • Evolution, Molecular
  • Cilia
  • Animals
  • 3105 Genetics
 

Citation

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Warner, J. F., McCarthy, A. M., Morris, R. L., & McClay, D. R. (2014). Hedgehog signaling requires motile cilia in the sea urchin. Molecular Biology and Evolution, 31(1), 18–22. https://doi.org/10.1093/molbev/mst176
Warner, Jacob F., Ali M. McCarthy, Robert L. Morris, and David R. McClay. “Hedgehog signaling requires motile cilia in the sea urchin.Molecular Biology and Evolution 31, no. 1 (January 2014): 18–22. https://doi.org/10.1093/molbev/mst176.
Warner JF, McCarthy AM, Morris RL, McClay DR. Hedgehog signaling requires motile cilia in the sea urchin. Molecular biology and evolution. 2014 Jan;31(1):18–22.
Warner, Jacob F., et al. “Hedgehog signaling requires motile cilia in the sea urchin.Molecular Biology and Evolution, vol. 31, no. 1, Jan. 2014, pp. 18–22. Epmc, doi:10.1093/molbev/mst176.
Warner JF, McCarthy AM, Morris RL, McClay DR. Hedgehog signaling requires motile cilia in the sea urchin. Molecular biology and evolution. 2014 Jan;31(1):18–22.
Journal cover image

Published In

Molecular biology and evolution

DOI

EISSN

1537-1719

ISSN

0737-4038

Publication Date

January 2014

Volume

31

Issue

1

Start / End Page

18 / 22

Related Subject Headings

  • Signal Transduction
  • Sea Urchins
  • Receptors, G-Protein-Coupled
  • Microscopy, Electron, Scanning
  • Hedgehog Proteins
  • Evolutionary Biology
  • Evolution, Molecular
  • Cilia
  • Animals
  • 3105 Genetics