Skip to main content
Journal cover image

The organization of submodality-specific touch afferent inputs in the vibrissa column.

Publication ,  Journal Article
Sakurai, K; Akiyama, M; Cai, B; Scott, A; Han, B-X; Takatoh, J; Sigrist, M; Arber, S; Wang, F
Published in: Cell Rep
October 17, 2013

The rodent tactile vibrissae are innervated by several different types of touch sensory neurons. The central afferents of all touch neurons from one vibrissa collectively project to a columnar structure called a barrelette in the brainstem. Delineating how distinct types of sensors connect to second-order neurons within each barrelette is critical for understanding tactile information coding and processing. Using genetic and viral techniques, we labeled slowly adapting (SA) mechanosensory neurons, rapidly adapting (RA) mechanosensory neurons, afferent synapses, and second-order projection neurons with four different fluorescent markers to examine their connectivity. We discovered that within each vibrissa column, individual sensory neurons project collaterals to multiply distributed locations, inputs from SA and RA afferents are spatially intermixed without any discernible stereotypy or topography, and second-order projection neurons receive convergent SA and RA inputs. Our findings reveal a "one-to-many and many-to-one" connectivity scheme and the circuit architecture for tactile information processing at the first-order synapses.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

October 17, 2013

Volume

5

Issue

1

Start / End Page

87 / 98

Location

United States

Related Subject Headings

  • Vibrissae
  • Touch
  • Neurons, Afferent
  • Mice, Transgenic
  • Mice
  • Brain Stem
  • Axons
  • Animals
  • 31 Biological sciences
  • 1116 Medical Physiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sakurai, K., Akiyama, M., Cai, B., Scott, A., Han, B.-X., Takatoh, J., … Wang, F. (2013). The organization of submodality-specific touch afferent inputs in the vibrissa column. Cell Rep, 5(1), 87–98. https://doi.org/10.1016/j.celrep.2013.08.051
Sakurai, Katsuyasu, Masahiro Akiyama, Bin Cai, Alexandra Scott, Bao-Xia Han, Jun Takatoh, Markus Sigrist, Silvia Arber, and Fan Wang. “The organization of submodality-specific touch afferent inputs in the vibrissa column.Cell Rep 5, no. 1 (October 17, 2013): 87–98. https://doi.org/10.1016/j.celrep.2013.08.051.
Sakurai K, Akiyama M, Cai B, Scott A, Han B-X, Takatoh J, et al. The organization of submodality-specific touch afferent inputs in the vibrissa column. Cell Rep. 2013 Oct 17;5(1):87–98.
Sakurai, Katsuyasu, et al. “The organization of submodality-specific touch afferent inputs in the vibrissa column.Cell Rep, vol. 5, no. 1, Oct. 2013, pp. 87–98. Pubmed, doi:10.1016/j.celrep.2013.08.051.
Sakurai K, Akiyama M, Cai B, Scott A, Han B-X, Takatoh J, Sigrist M, Arber S, Wang F. The organization of submodality-specific touch afferent inputs in the vibrissa column. Cell Rep. 2013 Oct 17;5(1):87–98.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

October 17, 2013

Volume

5

Issue

1

Start / End Page

87 / 98

Location

United States

Related Subject Headings

  • Vibrissae
  • Touch
  • Neurons, Afferent
  • Mice, Transgenic
  • Mice
  • Brain Stem
  • Axons
  • Animals
  • 31 Biological sciences
  • 1116 Medical Physiology