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CNS inflammation and bone marrow neuropathy in type 1 diabetes.

Publication ,  Journal Article
Hu, P; Thinschmidt, JS; Yan, Y; Hazra, S; Bhatwadekar, A; Caballero, S; Salazar, T; Miyan, JA; Li, W; Derbenev, A; Zsombok, A; Tikhonenko, M ...
Published in: Am J Pathol
November 2013

By using pseudorabies virus expressing green fluorescence protein, we found that efferent bone marrow-neural connections trace to sympathetic centers of the central nervous system in normal mice. However, this was markedly reduced in type 1 diabetes, suggesting a significant loss of bone marrow innervation. This loss of innervation was associated with a change in hematopoiesis toward generation of more monocytes and an altered diurnal release of monocytes in rodents and patients with type 1 diabetes. In the hypothalamus and granular insular cortex of mice with type 1 diabetes, bone marrow-derived microglia/macrophages were activated and found at a greater density than in controls. Infiltration of CD45(+)/CCR2(+)/GR-1(+)/Iba-1(+) bone marrow-derived monocytes into the hypothalamus could be mitigated by treatment with minocycline, an anti-inflammatory agent capable of crossing the blood-brain barrier. Our studies suggest that targeting central inflammation may facilitate management of microvascular complications.

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Published In

Am J Pathol

DOI

EISSN

1525-2191

Publication Date

November 2013

Volume

183

Issue

5

Start / End Page

1608 / 1620

Location

United States

Related Subject Headings

  • Sympathetic Nervous System
  • Rats, Wistar
  • Rats
  • Proto-Oncogene Proteins c-fos
  • Pathology
  • Neurotransmitter Agents
  • Neurons
  • Monocytes
  • Models, Biological
  • Minocycline
 

Citation

APA
Chicago
ICMJE
MLA
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Hu, P., Thinschmidt, J. S., Yan, Y., Hazra, S., Bhatwadekar, A., Caballero, S., … Grant, M. B. (2013). CNS inflammation and bone marrow neuropathy in type 1 diabetes. Am J Pathol, 183(5), 1608–1620. https://doi.org/10.1016/j.ajpath.2013.07.009
Hu, Ping, Jeffrey S. Thinschmidt, Yuanqing Yan, Sugata Hazra, Ashay Bhatwadekar, Sergio Caballero, Tatiana Salazar, et al. “CNS inflammation and bone marrow neuropathy in type 1 diabetes.Am J Pathol 183, no. 5 (November 2013): 1608–20. https://doi.org/10.1016/j.ajpath.2013.07.009.
Hu P, Thinschmidt JS, Yan Y, Hazra S, Bhatwadekar A, Caballero S, et al. CNS inflammation and bone marrow neuropathy in type 1 diabetes. Am J Pathol. 2013 Nov;183(5):1608–20.
Hu, Ping, et al. “CNS inflammation and bone marrow neuropathy in type 1 diabetes.Am J Pathol, vol. 183, no. 5, Nov. 2013, pp. 1608–20. Pubmed, doi:10.1016/j.ajpath.2013.07.009.
Hu P, Thinschmidt JS, Yan Y, Hazra S, Bhatwadekar A, Caballero S, Salazar T, Miyan JA, Li W, Derbenev A, Zsombok A, Tikhonenko M, Dominguez JM, McGorray SP, Saban DR, Boulton ME, Busik JV, Raizada MK, Chan-Ling T, Grant MB. CNS inflammation and bone marrow neuropathy in type 1 diabetes. Am J Pathol. 2013 Nov;183(5):1608–1620.
Journal cover image

Published In

Am J Pathol

DOI

EISSN

1525-2191

Publication Date

November 2013

Volume

183

Issue

5

Start / End Page

1608 / 1620

Location

United States

Related Subject Headings

  • Sympathetic Nervous System
  • Rats, Wistar
  • Rats
  • Proto-Oncogene Proteins c-fos
  • Pathology
  • Neurotransmitter Agents
  • Neurons
  • Monocytes
  • Models, Biological
  • Minocycline