Matthias Gromeier | Scholars@Duke

Matthias Gromeier
Professor of Neurosurgery

I am a classically trained virologist with a focus on molecular mechanisms of RNA virus pathogenesis. My career is dedicated to unraveling RNA virus:host relations and devising methods of exploiting them for cancer immunotherapy and vaccine design. My background is in translation regulation and mRNA metabolism, viral RNA sensing and innate immunity, and cancer immunology and immunotherapy. Basic mechanistic research in my laboratory is supporting an ambitious clinical translational research program with active multi-center clinical trials in several cancer indications.

Current Research Interests

Cancer Immunotherapy
Translation Control
+ssRNA Viruses
Poliovirus
Innate Immunology
Brain Tumors

Office Hours

N/A

Current Appointments & Affiliations

Professor of Neurosurgery, Neurosurgery, Neuro-Oncology, Neurosurgery 2016
Professor in Medicine, Medicine, Infectious Diseases, Medicine 2016
Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2016
Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1999

Contact Information

Box 3020 Med Ctr, Durham, NC 27710
Research Drive, Rm 423, Msrb1, Durham, NC 27710
grome001@mc.duke.edu (919) 668-6205
Gromeier Lab

Background
Education, Training, & Certifications
- Postdoctoral Associate, Molecular Genetics & Microbiology, State University of New York, Stony Brook 1996 - 1999
- Postdoctoral fellow, Molecular Genetics & Microbiology, State University of New York, Stony Brook 1993 - 1996
- M.D., University of Hamburg (Germany) 1992
Previous Appointments & Affiliations
- Associate Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2009 - 2016
- Associate Professor of Medicine, Medicine, Infectious Diseases, Medicine 2009 - 2016
- Associate Professor of Neurosurgery, Neurosurgery, Neurosurgery 2010 - 2016
- Associate Professor of Surgery, Neurosurgery, Neurosurgery 2009 - 2010
- Assistant Professor in Medicine, Medicine, Infectious Diseases, Medicine 2002 - 2009
- Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2009
- Assistant Professor of Surgery, Neurosurgery, Neuro-Oncology, Neurosurgery 2006 - 2009
- Assistant Professor of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1999 - 2002
Recognition
In the News
- MAY 4, 2023 Duke Today
  
  Duke Awards 44 Distinguished Professorships
- JAN 31, 2020 Duke Health News
  
  Poliovirus Therapy Shows Potential as Cancer Vaccine in Lab Studies
- SEP 20, 2017 Duke Health News
  
  Poliovirus Therapy Induces Immune Responses Against Cancer
- MAY 17, 2016 The Daily Mail
  
  Could polio help cure cancer? Therapy harnessing the virus 'destroys brain tumors'
- MAY 16, 2016
  
  Poliovirus Therapy Wins 'Breakthrough' Status
- MAY 13, 2016 CBS Evening News
  
  Promising brain cancer trial given breakthrough status by FDA
- MAR 18, 2016 Washington Examiner
  
  Dr. Matthias Gromeier: The right time to invest in cancer research
- FEB 10, 2016
  
  Vice President Visits to Discuss Cancer 'Moonshot'
- APR 1, 2015 WRAL
  
  Patients clamor for Duke cancer trial after '60 Minutes' report
- MAR 31, 2015 Forbes
  
  Commentary: What ‘60 Minutes’ got right and wrong on Duke's polio virus trial against glioblastoma
- MAR 31, 2015 Duke Research Blog
  
  When Bad Viruses Do Good
- APR 30, 2014 USA Today
  
  Poliovirus injected into brain kills student's cancer
- AUG 21, 2013 Al Jazeera America
  
  An unlikely cancer cure?
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas awarded by National Institutes of Health 2022 - 2027
- Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM awarded by National Institutes of Health 2022 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- PVSRIPO in melanoma awarded by National Institutes of Health 2020 - 2025
- Regional Oncolytic Poliovirus Immunotherapy for Breast Cancer awarded by Department of Defense 2016 - 2024
- Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2024
- Innate Antiviral Signals for Cancer Immunotherapy awarded by National Institutes of Health 2018 - 2023
- Identifying oncolytic viral therapy resistance mechanisms in brain tumors awarded by American Brain Tumor Association 2021 - 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2022
- T32 UNC - Duke Immunotherapy Training Program awarded by University of North Carolina - Chapel Hill 2021 - 2022
- The Role of CD155 in Leptomeningeal Dissemination and Oncolytic Virus Susceptibility in the Medulloblastoma Microenvironment awarded by Department of Defense 2018 - 2022
- Oncolytic Polovirus, Immunotoxin, and Checkpoint Inhibitor Therapy of Gliomas awarded by National Institutes of Health 2015 - 2022
- Understanding the Mechanism of Type-I/III Interferon Dominant Inflammation Induced by PVSRIPO Immunotherapy awarded by Brain Tumor Research Charity 2021 - 2022
- Establishing a Rationale for PVSRIPO Immunotherapy in Newly Diagnosed GBM awarded by National Brain Tumor Society 2019 - 2022
- Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma? awarded by National Institutes of Health 2019 - 2022
- Phase-1 clinical trial of PVSRIPO oncolytic immunotherapy in pediatric HGG awarded by Solving Kids' Cancer 2016 - 2021
- Poliovirus-Instigated APC Responses Against BRaf(V600E) for Pediatric Brain Tumor Immunotherapy awarded by V Foundation for Cancer Research 2018 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Cancer Immunotherapy Through Intratumoral Activation of Recall Responses awarded by National Cancer Center 2017 - 2019
- Oncolytic Immunotherapy of Glioblastoma with Recombinant Poliovirus awarded by Blast Glioblastoma 2015 - 2019
- Combining PVSRIPO Immunotherapy with Lomustine for the Treatment of Recurrent GBM awarded by National Brain Tumor Society 2017 - 2019
- Recombinant Attenuated Poliovirus Immunization Vectors Targeting H3.3(K27M) in DIPG awarded by Michael Mosier Defeat DIPG Foundation 2018 - 2019
- Targeting Translation Control in Malignant Glioma awarded by National Institutes of Health 2007 - 2018
- Oncolytic PVSRIPO Expressing Tumor Antigens as a Cancer Vaccine awarded by Oligo Nation 2016 - 2017
- Research Training In Neuro-Oncology awarded by National Institutes of Health 1998 - 2016
- Phase II/III Manufacture of the Oncolytic Poliovirus Chimera, PVSRIPO awarded by North Carolina Biotechnology Center 2015 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Oncolytic Poliovirus Immunotherapy of Malignant Glioma awarded by The Slomo and Cindy Silvian Foundation, Inc 2014 - 2015
- Oncolytic Virotherapy of Meningeal Cancer awarded by National Institutes of Health 2009 - 2015
- Instrumentation for Quantitative Phosphoproteomics and Acetylomics awarded by National Institutes of Health 2014 - 2015
- Oncolytic poliovirus therapy of malignant glioma awarded by Southeastern Brain Tumor Foundation 2014 - 2015
- Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy awarded by National Institutes of Health 2009 - 2012
- Transgenic Mouse Model for the Common Cold awarded by National Institutes of Health 2008 - 2010
- Research Training In Neuro-Oncology awarded by National Institutes of Health 2005 - 2010
- Cis and Trans-acting Factors in HCV Gene Expression awarded by National Institutes of Health 2005 - 2008
- Cell Type-Specific Viral Translation in the CNS awarded by National Institutes of Health 2002 - 2007
- TARGETING BREAST CANCER CNS METASTASIS WITH ONCOLYTIC POLIOVIRUSES Targeted Breast Cancer CNS Metastasis with Oncolytic Polioviruses awarded by United States Army Medical Research and Materiel Command 2004 - 2005
- Cell Type-Specific Viral Translation in the CNS awarded by National Institutes of Health 2003 - 2005
- Genetically stable Picornavirus HIV Immunization vectors awarded by National Institutes of Health 2003 - 2005
- Production of non-pathogenic oncolytic poliovirus chimeras for the treatment of brain tumors (Project #417) awarded by National Institutes of Health 2001 - 2002
- Production of non-pathogenic oncolytic poliovirus chimeras for the treatment of brain tumors awarded by National Institutes of Health 2000 - 2001
External Relationships
- Istari Oncology Inc.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Brown, Michael C., Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, et al. “Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils.” J Immunother Cancer 11, no. 4 (April 2023). https://doi.org/10.1136/jitc-2022-006463.
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  - Thompson, Eric M., Daniel Landi, Michael C. Brown, Henry S. Friedman, Roger McLendon, James E. Herndon, Evan Buckley, et al. “Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.” Lancet Child Adolesc Health, March 30, 2023. https://doi.org/10.1016/S2352-4642(23)00031-7.
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  - Li, Sean, Roger McLendon, Eric Sankey, Reb Kornahrens, Anne-Marie Lyne, Florence Marie Géraldine Cavalli, Zachary McKay, et al. “CD155 is a putative therapeutic target in medulloblastoma.” Clin Transl Oncol 25, no. 3 (March 2023): 696–705. https://doi.org/10.1007/s12094-022-02975-9.
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  - Beasley, Georgia M., Michael C. Brown, Norma E. Farrow, Karenia Landa, Rami N. Al-Rohil, Maria Angelica Selim, Aaron D. Therien, et al. “Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma.” J Immunother Cancer 10, no. 9 (September 2022). https://doi.org/10.1136/jitc-2022-005052.
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  - Dobrikov, Mikhail I., Elena Y. Dobrikova, Zachary P. McKay, Jonathan P. Kastan, Michael C. Brown, and Matthias Gromeier. “PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.” Mbio 13, no. 3 (June 28, 2022): e0085422. https://doi.org/10.1128/mbio.00854-22.
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  - Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.
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  - Kastan, Jonathan P., Martine W. Tremblay, Michael C. Brown, Joseph D. Trimarco, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.” Mbio 12, no. 2 (April 13, 2021). https://doi.org/10.1128/mBio.00116-21.
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  - Beasley, Georgia M., Smita K. Nair, Norma E. Farrow, Karenia Landa, Maria Angelica Selim, Carol Ann Wiggs, Sin-Ho Jung, et al. “Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma.” J Immunother Cancer 9, no. 4 (April 2021). https://doi.org/10.1136/jitc-2020-002203.
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  - Brown, Michael C., Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, et al. “Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.” Nat Commun 12, no. 1 (March 25, 2021): 1858. https://doi.org/10.1038/s41467-021-22088-1.
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  - McKay, Zachary P., Michael C. Brown, and Matthias Gromeier. “Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression.” J Immunol 206, no. 6 (March 15, 2021): 1385–94. https://doi.org/10.4049/jimmunol.2000792.
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  - Gromeier, Matthias, Michael C. Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, et al. “Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.” Nat Commun 12, no. 1 (January 13, 2021): 352. https://doi.org/10.1038/s41467-020-20469-6.
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  - Mosaheb, Mubeen M., Michael C. Brown, Elena Y. Dobrikova, Mikhail I. Dobrikov, and Matthias Gromeier. “Harnessing virus tropism for dendritic cells for vaccine design.” Curr Opin Virol 44 (October 2020): 73–80. https://doi.org/10.1016/j.coviro.2020.07.012.
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  - Kastan, Jonathan P., Elena Y. Dobrikova, Jeffrey D. Bryant, and Matthias Gromeier. “CReP mediates selective translation initiation at the endoplasmic reticulum.” Sci Adv 6, no. 23 (June 2020): eaba0745. https://doi.org/10.1126/sciadv.aba0745.
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  - Mosaheb, Mubeen M., Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, and Matthias Gromeier. “Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity.” Nat Commun 11, no. 1 (January 27, 2020): 524. https://doi.org/10.1038/s41467-019-13939-z.
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  - Chandramohan, Vidyalakshmi, Xuhui Bao, Xin Yu, Scott Parker, Charlotte McDowall, Yen-Rei Yu, Patrick Healy, et al. “Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.” J Immunother Cancer 7, no. 1 (May 29, 2019): 142. https://doi.org/10.1186/s40425-019-0614-0.
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  - Yu, Xin, Mikhail Dobrikov, Stephen T. Keir, Matthias Gromeier, Ira H. Pastan, Ralph Reisfeld, Darell D. Bigner, and Vidyalakshmi Chandramohan. “Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.” Plos One 14, no. 1 (2019): e0210608. https://doi.org/10.1371/journal.pone.0210608.
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  - Dobrikov, Mikhail I., Elena Y. Dobrikova, and Matthias Gromeier. “Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding.” Mol Cell Biol 38, no. 19 (October 1, 2018). https://doi.org/10.1128/MCB.00306-18.
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  - Dobrikov, Mikhail I., Elena Y. Dobrikova, and Matthias Gromeier. “Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.” Mol Cell Biol 38, no. 19 (October 1, 2018). https://doi.org/10.1128/MCB.00304-18.
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  - Walton, Ross W., Michael C. Brown, Matthew T. Sacco, and Matthias Gromeier. “Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells.” J Virol 92, no. 19 (October 1, 2018). https://doi.org/10.1128/JVI.00879-18.
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  - Thompson, Eric M., Michael Brown, Elena Dobrikova, Vijay Ramaswamy, Michael D. Taylor, Roger McLendon, Jennifer Sanks, Vidya Chandramohan, Darell Bigner, and Matthias Gromeier. “Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma.” J Neuropathol Exp Neurol 77, no. 8 (August 1, 2018): 696–702. https://doi.org/10.1093/jnen/nly045.
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  - Desjardins, Annick, Matthias Gromeier, James E. Herndon, Nike Beaubier, Dani P. Bolognesi, Allan H. Friedman, Henry S. Friedman, et al. “Recurrent Glioblastoma Treated with Recombinant Poliovirus.” N Engl J Med 379, no. 2 (July 12, 2018): 150–61. https://doi.org/10.1056/NEJMoa1716435.
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  - Bryant, Jeffrey D., Michael C. Brown, Mikhail I. Dobrikov, Elena Y. Dobrikova, Sarah L. Gemberling, Qing Zhang, and Matthias Gromeier. “Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.” Mol Cell Biol 38, no. 11 (June 1, 2018). https://doi.org/10.1128/MCB.00647-17.
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  - Evans, Myron K., Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, et al. “XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.” Cancer Res 78, no. 7 (April 1, 2018): 1726–38. https://doi.org/10.1158/0008-5472.CAN-17-1667.
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  - Gromeier, Matthias, and Smita K. Nair. “Recombinant Poliovirus for Cancer Immunotherapy.” Annu Rev Med 69 (January 29, 2018): 289–99. https://doi.org/10.1146/annurev-med-050715-104655.
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  - Chandramohan, Vidyalakshmi, Jeffrey D. Bryant, Hailan Piao, Stephen T. Keir, Eric S. Lipp, Michaela Lefaivre, Kathryn Perkinson, Darell D. Bigner, Matthias Gromeier, and Roger E. McLendon. “Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas.” Arch Pathol Lab Med 141, no. 12 (December 2017): 1697–1704. https://doi.org/10.5858/arpa.2016-0580-OA.
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  - Brown, Michael C., Eda K. Holl, David Boczkowski, Elena Dobrikova, Mubeen Mosaheb, Vidya Chandramohan, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.” Sci Transl Med 9, no. 408 (September 20, 2017). https://doi.org/10.1126/scitranslmed.aan4220.
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  - Brown, Michael C., and Matthias Gromeier. “MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.” Cell Rep 18, no. 6 (February 7, 2017): 1444–57. https://doi.org/10.1016/j.celrep.2017.01.023.
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  - Brown, Michael C., and Matthias Gromeier. “MNK inversely regulates TELO2 vs. DEPTOR to control mTORC1 signaling.” Mol Cell Oncol 4, no. 3 (2017): e1306010. https://doi.org/10.1080/23723556.2017.1306010.
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  - Holl, Eda K., Michael C. Brown, David Boczkowski, Megan A. McNamara, Daniel J. George, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.” Oncotarget 7, no. 48 (November 29, 2016): 79828–41. https://doi.org/10.18632/oncotarget.12975.
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  - Brown, Michael C., Eda K. Holl, David Boczkowski, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Abstract A157: Oncolytic poliovirus mediated immune events.” Cancer Immunology Research 4, no. 1_Supplement (January 1, 2016): A157–A157. https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a157.
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  - Brown, Michael C., and Matthias Gromeier. “Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus.” Curr Opin Virol 13 (August 2015): 81–85. https://doi.org/10.1016/j.coviro.2015.05.007.
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  - Brown, Michael C., and Matthias Gromeier. “Oncolytic immunotherapy through tumor-specific translation and cytotoxicity of poliovirus.” Discov Med 19, no. 106 (May 2015): 359–65.
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  - Brown, Michael C., Elena Y. Dobrikova, Mikhail I. Dobrikov, Ross W. Walton, Sarah L. Gemberling, Smita K. Nair, Annick Desjardins, et al. “Oncolytic polio virotherapy of cancer.” Cancer 120, no. 21 (November 1, 2014): 3277–86. https://doi.org/10.1002/cncr.28862.
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  - Brown, Michael C., Jeffrey D. Bryant, Elena Y. Dobrikova, Mayya Shveygert, Shelton S. Bradrick, Vidyalakshmi Chandramohan, Darell D. Bigner, and Matthias Gromeier. “Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.” J Virol 88, no. 22 (November 2014): 13135–48. https://doi.org/10.1128/JVI.01883-14.
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  - Brown, Michael C., Mikhail I. Dobrikov, and Matthias Gromeier. “Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.” J Virol 88, no. 22 (November 2014): 13149–60. https://doi.org/10.1128/JVI.01884-14.
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  - Desjardins, A., J. Sampson, K. Peters, G. Vlahovic, S. Threatt, J. Herndon, S. Boulton, et al. “AT-21 * FINAL RESULTS OF A PHASE 1 TRIAL OF AN ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) AGAINST RECURRENT GLIOBLASTOMA (GBM).” Neuro Oncology 16, no. suppl 5 (November 1, 2014): v13–v13. https://doi.org/10.1093/neuonc/nou237.21.
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  - Desjardins, A., J. H. Sampson, K. B. Peters, T. Ranjan, G. Vlahovic, S. Threatt, J. E. Herndon, et al. “Oncolytic polio/rhinovirus recombinant (pvsripo) in recurrent glioblastoma (gbm): first phase I clinical trial evaluating the intratumoral administration.” Neuro Oncol 16 Suppl 3 (July 2014): iii43. https://doi.org/10.1093/neuonc/nou209.5.
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  - Gromeier, M., E. Dobrikova, M. Dobrikov, M. Brown, J. Bryant, S. Threatt, S. Boulton, et al. “Oncolytic poliovirus immunotherapy of glioblastoma.” Neuro Oncol 16 Suppl 3 (July 2014): iii41. https://doi.org/10.1093/neuonc/nou208.69.
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  - Dobrikov, Mikhail I., Mayya Shveygert, Michael C. Brown, and Matthias Gromeier. “Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.” Mol Cell Biol 34, no. 3 (February 2014): 439–51. https://doi.org/10.1128/MCB.01046-13.
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  - Sampson, J. H., A. Desjardins, K. B. Peters, T. Ranjan, G. Vlahovic, D. Lally-Goss, S. Threatt, et al. “107 Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma.” Neurosurgery 60 Suppl 1 (August 2013): 155. https://doi.org/10.1227/01.neu.0000432699.02392.a4.
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  - Chandramohan, V., D. A. Mitchell, M. Gromeier, J. H. Sampson, and D. D. Bigner. “Current immunotherapeutic targets in gliomas,” May 1, 2013, 287–305.
  - Dobrikov, Mikhail I., Elena Y. Dobrikova, and Matthias Gromeier. “Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G.” Mol Cell Biol 33, no. 5 (March 2013): 937–46. https://doi.org/10.1128/MCB.01441-12.
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  - Barton, Kelly L., Katherine Misuraca, Francisco Cordero, Elena Dobrikova, Hooney D. Min, Matthias Gromeier, David G. Kirsch, and Oren J. Becher. “PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.” Plos One 8, no. 10 (2013): e77639. https://doi.org/10.1371/journal.pone.0077639.
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  - Lawson, Sarah K., Elena Y. Dobrikova, Mayya Shveygert, and Matthias Gromeier. “p38α mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons.” Mol Cell Biol 33, no. 1 (January 2013): 127–35. https://doi.org/10.1128/MCB.00695-12.
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  - Dobrikova, Elena Y., Christian Goetz, Robert W. Walters, Sarah K. Lawson, James O. Peggins, Karen Muszynski, Sheryl Ruppel, et al. “Attenuation of neurovirulence, biodistribution, and shedding of a poliovirus:rhinovirus chimera after intrathalamic inoculation in Macaca fascicularis.” J Virol 86, no. 5 (March 2012): 2750–59. https://doi.org/10.1128/JVI.06427-11.
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  - Goetz, Christian, Elena Dobrikova, Mayya Shveygert, Mikhail Dobrikov, and Matthias Gromeier. “Oncolytic poliovirus against malignant glioma.” Future Virol 6, no. 9 (September 2011): 1045–58. https://doi.org/10.2217/fvl.11.76.
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  - Dobrikov, Mikhail, Elena Dobrikova, Mayya Shveygert, and Matthias Gromeier. “Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.” Mol Cell Biol 31, no. 14 (July 2011): 2947–59. https://doi.org/10.1128/MCB.05589-11.
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  - Wang, Eric S., Elena Dobrikova, Christian Goetz, Andrew T. Dufresne, and Matthias Gromeier. “Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract.” J Virol 85, no. 11 (June 2011): 5606–17. https://doi.org/10.1128/JVI.01502-10.
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  - Goetz, Christian, Richard G. Everson, Linda C. Zhang, and Matthias Gromeier. “MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus.” Mol Ther 18, no. 11 (November 2010): 1937–46. https://doi.org/10.1038/mt.2010.145.
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  - Shveygert, Mayya, Constanze Kaiser, Shelton S. Bradrick, and Matthias Gromeier. “Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction.” Mol Cell Biol 30, no. 21 (November 2010): 5160–67. https://doi.org/10.1128/MCB.00448-10.
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  - Neplioueva, Valentina, Elena Y. Dobrikova, Neelanjan Mukherjee, Jack D. Keene, and Matthias Gromeier. “Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs.” Plos One 5, no. 7 (July 23, 2010): e11710. https://doi.org/10.1371/journal.pone.0011710.
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  - Dobrikova, Elena, Mayya Shveygert, Robert Walters, and Matthias Gromeier. “Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution.” J Virol 84, no. 1 (January 2010): 270–79. https://doi.org/10.1128/JVI.01740-09.
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  - Walters, Robert W., Shelton S. Bradrick, and Matthias Gromeier. “Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression.” Rna 16, no. 1 (January 2010): 239–50. https://doi.org/10.1261/rna.1795410.
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  - Goetz, Christian, and Matthias Gromeier. “Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme.” Cytokine Growth Factor Rev 21, no. 2–3 (2010): 197–203. https://doi.org/10.1016/j.cytogfr.2010.02.005.
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  - Bradrick, Shelton S., and Matthias Gromeier. “Identification of gemin5 as a novel 7-methylguanosine cap-binding protein.” Plos One 4, no. 9 (September 14, 2009): e7030. https://doi.org/10.1371/journal.pone.0007030.
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  - Gromeier, Matthias, Valentina Neplioueva, Neel Makherjee, Melinda Merrill, and John H. Sampson. “THE RNA-BINDING PROTEIN 76 CONTROLS GENE EXPRESSION IN GBM.” Neuro Oncology 11, no. 2 (April 1, 2009): 221–221.
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  - Yang, Xiaoyi, Eying Chen, Hengguang Jiang, Karen Muszynski, Raymond D. Harris, Steven L. Giardina, Matthias Gromeier, Gautam Mitra, and Gopalan Soman. “Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay.” J Virol Methods 155, no. 1 (January 2009): 44–54. https://doi.org/10.1016/j.jviromet.2008.09.020.
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  - Dobrikova, Elena Y., Trevor Broadt, Judith Poiley-Nelson, Xiaoyi Yang, Gopalan Soman, Steve Giardina, Ray Harris, and Matthias Gromeier. “Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype.” Mol Ther 16, no. 11 (November 2008): 1865–72. https://doi.org/10.1038/mt.2008.184.
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  - Kaiser, Constanze, Elena Y. Dobrikova, Shelton S. Bradrick, Mayya Shveygert, James T. Herbert, and Matthias Gromeier. “Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo.” Rna 14, no. 10 (October 2008): 2170–82. https://doi.org/10.1261/rna.1171808.
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  - Everson, Richard G., Michael W. Graner, Matthias Gromeier, James J. Vredenburgh, Annick Desjardins, David A. Reardon, Henry S. Friedman, Allan H. Friedman, Darell D. Bigner, and John H. Sampson. “Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.” Expert Rev Anticancer Ther 8, no. 5 (May 2008): 717–32. https://doi.org/10.1586/14737140.8.5.717.
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  - Selznick, Lee A., Mohammed F. Shamji, Peter Fecci, Matthias Gromeier, Allan H. Friedman, and John Sampson. “Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines.” Neurosurg Rev 31, no. 2 (April 2008): 141–55. https://doi.org/10.1007/s10143-008-0121-0.
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  - Cello, Jeronimo, Hidemi Toyoda, Nidia Dejesus, Elena Y. Dobrikova, Matthias Gromeier, and Eckard Wimmer. “Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses.” J Med Virol 80, no. 2 (February 2008): 352–59. https://doi.org/10.1002/jmv.21063.
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  - Bradrick, Shelton S., Elena Y. Dobrikova, Constanze Kaiser, Mayya Shveygert, and Matthias Gromeier. “Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosome entry sites.” Rna 13, no. 9 (September 2007): 1582–93. https://doi.org/10.1261/rna.556107.
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  - Florez de Sessions, Paola, Elena Dobrikova, and Matthias Gromeier. “Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD.” J Virol 81, no. 16 (August 2007): 8396–8405. https://doi.org/10.1128/JVI.00321-07.
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  - Everson, Richard G., Mathias Gromeier, and John H. Sampson. “Viruses in the treatment of malignant glioma.” Expert Rev Neurother 7, no. 4 (April 2007): 321–24. https://doi.org/10.1586/14737175.7.4.321.
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  - Campbell, Stephanie A., Matthew Mulvey, Ian Mohr, and Matthias Gromeier. “Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements.” J Virol 81, no. 2 (January 2007): 791–99. https://doi.org/10.1128/JVI.00714-06.
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  - Merrill, Melinda K., and Matthias Gromeier. “The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site.” J Virol 80, no. 14 (July 2006): 6936–42. https://doi.org/10.1128/JVI.00243-06.
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  - Dobrikova, Elena Y., Rachel N. Grisham, Constanze Kaiser, Jennifer Lin, and Matthias Gromeier. “Competitive translation efficiency at the picornavirus type 1 internal ribosome entry site facilitated by viral cis and trans factors.” J Virol 80, no. 7 (April 2006): 3310–21. https://doi.org/10.1128/JVI.80.7.3310-3321.2006.
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  - Merrill, Melinda K., Elena Y. Dobrikova, and Matthias Gromeier. “Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76.” J Virol 80, no. 7 (April 2006): 3147–56. https://doi.org/10.1128/JVI.80.7.3147-3156.2006.
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  - Merrill, M. K., L. A. Selznick, and M. Gromeier. “Oncolytic viruses for the treatment of malignant glioma.” Expert Opinion on Therapeutic Patents 16, no. 3 (March 1, 2006): 363–71. https://doi.org/10.1517/13543776.16.3.363.
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  - Ochiai, Hidenobu, Stephanie A. Campbell, Gary E. Archer, Tracy A. Chewning, Eugenia Dragunsky, Alexander Ivanov, Matthias Gromeier, and John H. Sampson. “Targeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus.” Clin Cancer Res 12, no. 4 (February 15, 2006): 1349–54. https://doi.org/10.1158/1078-0432.CCR-05-1595.
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  - Bradrick, Shelton S., Robert W. Walters, and Matthias Gromeier. “The hepatitis C virus 3'-untranslated region or a poly(A) tract promote efficient translation subsequent to the initiation phase.” Nucleic Acids Res 34, no. 4 (2006): 1293–1303. https://doi.org/10.1093/nar/gkl019.
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  - Dufresne, A. T., and M. Gromeier. “Understanding polio: New insights from a cold virus.” Microbe 1, no. 1 (January 1, 2006): 13–18.
  - Campbell, Stephanie A., Jennifer Lin, Elena Y. Dobrikova, and Matthias Gromeier. “Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells.” J Virol 79, no. 10 (May 2005): 6281–90. https://doi.org/10.1128/JVI.79.10.6281-6290.2005.
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  - Florez, Paola M., October M. Sessions, Eric J. Wagner, Matthias Gromeier, and Mariano A. Garcia-Blanco. “The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation.” J Virol 79, no. 10 (May 2005): 6172–79. https://doi.org/10.1128/JVI.79.10.6172-6179.2005.
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  - Moore, S. A., M. K. Merrill, and M. Gromeier. “Treatment of CNS malignancies with a recombinant oncolytic poliovirus.” Drug Design Reviews Online 2, no. 3 (May 1, 2005): 233–41. https://doi.org/10.2174/1567269053828774.
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  - Campbell, Stephanie A., and Matthias Gromeier. “Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells.” Onkologie 28, no. 4 (April 2005): 209–15. https://doi.org/10.1159/000084010.
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  - Campbell, Stephanie A., and Matthias Gromeier. “Oncolytic viruses for cancer therapy I. Cell-external factors: virus entry and receptor interaction.” Onkologie 28, no. 3 (March 2005): 144–49. https://doi.org/10.1159/000083659.
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  - Dufresne, Andrew T., and Matthias Gromeier. “A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice.” Proc Natl Acad Sci U S A 101, no. 37 (September 14, 2004): 13636–41. https://doi.org/10.1073/pnas.0403998101.
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  - Ochiai, Hidenobu, Stephanie A. Moore, Gary E. Archer, Tatsunori Okamura, Tracy A. Chewning, Jeffrey R. Marks, John H. Sampson, and Matthias Gromeier. “Treatment of intracerebral neoplasia and neoplastic meningitis with regional delivery of oncolytic recombinant poliovirus.” Clin Cancer Res 10, no. 14 (July 15, 2004): 4831–38. https://doi.org/10.1158/1078-0432.CCR-03-0694.
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  - Merrill, Melinda K., Guenter Bernhardt, John H. Sampson, Carol J. Wikstrand, Darell D. Bigner, and Matthias Gromeier. “Poliovirus receptor CD155-targeted oncolysis of glioma.” Neuro Oncol 6, no. 3 (July 2004): 208–17. https://doi.org/10.1215/S1152851703000577.
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  - Scheuner, Donalyn, Matthias Gromeier, Monique V. Davies, Andrew J. Dorner, Benbo Song, Rupali V. Patel, Eckard J. Wimmer, Roger E. McLendon, and Randal J. Kaufman. “The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis.” Virology 317, no. 2 (December 20, 2003): 263–74. https://doi.org/10.1016/j.virol.2003.08.010.
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  - Dobrikova, Elena, Paola Florez, Shelton Bradrick, and Matthias Gromeier. “Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region.” Proc Natl Acad Sci U S A 100, no. 25 (December 9, 2003): 15125–30. https://doi.org/10.1073/pnas.2436464100.
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  - Gromeier, M. “Oncolytic Viruses for Cancer Therapy.” American Journal of Cancer 2, no. 5 (November 27, 2003): 313–23. https://doi.org/10.2165/00024669-200302050-00002.
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  - Dobrikova, Elena Y., Paola Florez, and Matthias Gromeier. “Structural determinants of insert retention of poliovirus expression vectors with recombinant IRES elements.” Virology 311, no. 2 (July 5, 2003): 241–53. https://doi.org/10.1016/s0042-6822(03)00191-0.
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  - Fecci, Peter E., Matthias Gromeier, and John H. Sampson. “Viruses in the treatment of brain tumors.” Neuroimaging Clin N Am 12, no. 4 (November 2002): 553–70. https://doi.org/10.1016/s1052-5149(02)00028-x.
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  - Dufresne, Andrew T., Elena Y. Dobrikova, Stacie Schmidt, and Matthias Gromeier. “Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites.” J Virol 76, no. 17 (September 2002): 8966–72. https://doi.org/10.1128/jvi.76.17.8966-8972.2002.
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  - Gromeier, M. “Viruses for treating cancer.” Asm News 68, no. 9 (September 1, 2002): 438-+.
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  - Solecki, David J., Matthias Gromeier, Steffen Mueller, Günter Bernhardt, and Eckard Wimmer. “Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog.” J Biol Chem 277, no. 28 (July 12, 2002): 25697–702. https://doi.org/10.1074/jbc.M201378200.
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  - Gromeier, M., and E. Wimmer. “Viruses for the treatment of malignant glioma.” Curr Opin Mol Ther 3, no. 5 (October 2001): 503–8.
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  - Gromeier, M. “Viruses as therapeutic agents against malignant disease of the central nervous system.” J Natl Cancer Inst 93, no. 12 (June 20, 2001): 889–90. https://doi.org/10.1093/jnci/93.12.889.
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  - Chumakov, K., E. Dragunsky, A. Ivshina, J. Enterline, V. Wells, T. Nomura, M. Gromeier, and E. Wimmer. “Inactivated vaccines based on alternatives to wild-type seed virus.” Dev Biol (Basel) 105 (2001): 171–77.
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  - Gromeier, M., D. Solecki, D. D. Patel, and E. Wimmer. “Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis.” Virology 273, no. 2 (August 1, 2000): 248–57. https://doi.org/10.1006/viro.2000.0418.
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  - Gromeier, M., S. Lachmann, M. R. Rosenfeld, P. H. Gutin, and E. Wimmer. “Intergeneric poliovirus recombinants for the treatment of malignant glioma.” Proc Natl Acad Sci U S A 97, no. 12 (June 6, 2000): 6803–8. https://doi.org/10.1073/pnas.97.12.6803.
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  - GROMEIER, M. “Intergeneric poliovirus recombinants for the treatment of malignant glioma.” Proc Natl Acad Sci Usa 97 (2000): 6803–8.
  - Gromeier, M., B. Bossert, M. Arita, A. Nomoto, and E. Wimmer. “Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence.” J Virol 73, no. 2 (February 1999): 958–64. https://doi.org/10.1128/JVI.73.2.958-964.1999.
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  - McCloskey, B. P. “The relation of prophylactic inoculations to the onset of poliomyelitis. 1950.” Rev Med Virol 9, no. 4 (1999): 219–26. https://doi.org/10.1002/(sici)1099-1654(199910/12)9:4<219::aid-rmv249>3.0.co;2-t.
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  - Das, S., M. Ott, A. Yamane, W. M. Tsai, M. Gromeier, F. Lahser, S. Gupta, and A. Dasgupta. “A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element (vol 72, pg 5638, 1998).” Journal of Virology 72, no. 11 (November 1, 1998): 9419–9419.
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  - Das, S., M. Ott, A. Yamane, W. Tsai, M. Gromeier, F. Lahser, S. Gupta, and A. Dasgupta. “A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element.” J Virol 72, no. 7 (July 1998): 5638–47. https://doi.org/10.1128/JVI.72.7.5638-5647.1998.
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  - Gromeier, M., and E. Wimmer. “Mechanism of injury-provoked poliomyelitis.” J Virol 72, no. 6 (June 1998): 5056–60. https://doi.org/10.1128/JVI.72.6.5056-5060.1998.
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  - Das, S., M. Ott, A. Yamane, W. Tsai, M. Gromeier, F. Lahser, S. Gupta, and A. Dasgupta. “Erratum: A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element (Journal of Virology (1998) 72:7 (5638-5647)).” Journal of Virology 72, no. 11 (January 1, 1998): 9419.
  - GROMEIER, M. “Mechanism of injury-provoked poliomyelitis.” J. Virol. 72 (1998): 5056–60.
  - Solecki, D., M. Gromeier, J. Harber, G. Bernhardt, and E. Wimmer. “Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction.” J Mol Recognit 11, no. 1–6 (1998): 2–9. https://doi.org/10.1002/(SICI)1099-1352(199812)11:1/6<2::AID-JMR380>3.0.CO;2-D.
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  - Duggal, R., A. Cuconati, M. Gromeier, and E. Wimmer. “Genetic recombination of poliovirus in a cell-free system.” Proc Natl Acad Sci U S A 94, no. 25 (December 9, 1997): 13786–91. https://doi.org/10.1073/pnas.94.25.13786.
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  - Gromeier, M., S. Mueller, D. Solecki, B. Bossert, G. Bernhardt, and E. Wimmer. “Determinants of poliovirus neurovirulence.” J Neurovirol 3 Suppl 1 (May 1997): S35–38.
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  - Gromeier, M., L. Alexander, and E. Wimmer. “Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.” Proc Natl Acad Sci U S A 93, no. 6 (March 19, 1996): 2370–75. https://doi.org/10.1073/pnas.93.6.2370.
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  - GROMEIER, M. “Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.” Proc Natl Acad Sci Usa 93 (1996): 2370–75.
  - Gromeier, M., H. H. Lu, G. Bernhardt, J. J. Harber, J. A. Bibb, and E. Wimmer. “The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity.” Ann N Y Acad Sci 753 (May 25, 1995): 19–36. https://doi.org/10.1111/j.1749-6632.1995.tb27528.x.
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  - Gromeier, M., H. H. Lu, and E. Wimmer. “Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis.” Microb Pathog 18, no. 4 (April 1995): 253–67. https://doi.org/10.1016/s0882-4010(05)80002-6.
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  - Alexander, L., H. H. Lu, M. Gromeier, and E. Wimmer. “Dicistronic polioviruses as expression vectors for foreign genes.” Aids Res Hum Retroviruses 10 Suppl 2 (1994): S57–60.
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  - Gromeier, M., and K. Wetz. “Kinetics of poliovirus uncoating in HeLa cells in a nonacidic environment.” J Virol 64, no. 8 (August 1990): 3590–97. https://doi.org/10.1128/JVI.64.8.3590-3597.1990.
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- Book Sections
  - Merrill, M., D. Solecki, and M. Gromeier. “Poliovirus recombinants against malignant glioma.” In Viral Therapy of Human Cancers, 739–80, 2004.
- Conference Papers
  - Brown, Michael, Zachary McKay, Yuanfan Yang, Darell Bigner, Smita Nair, and Matthias Gromeier. “739 Intratumor childhood vaccine-specific CD4+ T cell recall helps antitumor CD8 T cells.” In Journal for Immunotherapy of Cancer, 9:A770–A770. BMJ, 2021. https://doi.org/10.1136/jitc-2021-sitc2021.739.
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  - Neighbours, Lauren, Zachary P. McKay, Matthias Gromeier, Garrett Nichols, Andrea True Kelly, Daniel Corum, and Michael Brown. “Safety and efficacy of murine PVSRIPO plus anti-PD-1 immune checkpoint inhibitor (ICI) in a melanoma tumor model.” In Journal of Clinical Oncology, 39:2560–2560. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.15_suppl.2560.
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  - Sloan, Andrew E., Robin Arthur Buerki, Christopher Murphy, Andrea True Kelly, Prakash Ambady, Michael Brown, Nicholas A. Butowski, et al. “LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma.” In Journal of Clinical Oncology, 39:TPS2065–TPS2065. American Society of Clinical Oncology (ASCO), 2021. https://doi.org/10.1200/jco.2021.39.15_suppl.tps2065.
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  - Brown, Michael, Gao Zhang, Kevin Stevenson, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, et al. “TUMOR-INTRINSIC AND PERIPHERAL FEATURES ASSOCIATE WITH SURVIVAL AFTER POLIO VIROTHERAPY IN RECURRENT GBM.” In Neuro Oncology, 23:14–14, 2021.
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  - Desjardins, Annick, Matthias Gromeier, Henry Friedman, Daniel Landi, Allan Friedman, David M. Ashley, William Curry, et al. “SAFETY AND EFFICACY OF PVSRIPO IN RECURRENT GLIOBLASTOMA: LONG-TERM FOLLOW-UP AND INITIAL MULTICENTER RESULTS.” In Neuro Oncology, 23:97–97, 2021.
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  - Kelly, Andrea True, Prakash Ambady, Michael Brown, Nicholas Butowski, Robert Cavaliere, William Curry, Annick Desjardins, et al. “LUMINOS-101: Phase 2 study of PVSRIPO with pembrolizumab in recurrent glioblastoma.” In Cancer Research, Vol. 81, 2021.
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  - Low, Justin, Vidyalakshmi Chandramohan, Michelle Bowie, Michael Brown, Matthew Waitkus, Aaron Briley, Kevin Stevenson, et al. “STING IS SILENCED IN GBM BY PROMOTER METHYLATION THAT IS ESTABLISHED BY TISSUE OF ORIGIN.” In Neuro Oncology, 23:4–4, 2021.
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  - Yang, Yuanfan, Michael Brown, Kevin Stevenson, Giselle Lopez, Reb Kornahrens, Gao Zhang, and Matthias Gromeier. “POLIO VIROTHERAPY OF MURINE BRAIN TUMORS INDUCES MICROGLIA PROLIFERATION AND INFLAMMATION THAT IS POTENTIATED BY IMMUNE CHECKPOINT BLOCKADE.” In Neuro Oncology, 23:181–181, 2021.
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  - Beasley, Georgia, Nellie Farrow, Karenia Landa, Maria Angelica Seilm, Sin-Ho Jung, Darell Bigner, Andrea True Kelly, Smita Nair, Matthias Gromeier, and April Salama. “302 A phase I trial of intratumoral PVSRIPO in patients with unresectable treatment refractory melanoma.” In Regular and Young Investigator Award Abstracts. BMJ Publishing Group Ltd, 2020. https://doi.org/10.1136/jitc-2020-sitc2020.0302.
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  - Thompson, Eric M., Eric Thompson, Wafa Hassen, Meredith McDonald, Daniel Picard, Michael Brown, Elena Dobrikova, and Matthias Gromeier. “Poliovirus Oncolytic Activity in Medulloblastoma is Mediated by Oxidative Stress.” In Journal of Neurosurgery, 132:115–115. AMER ASSOC NEUROLOGICAL SURGEONS, 2020.
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  - Farrow, N. E., G. M. Beasley, A. S. MacLeod, M. A. Sarah, A. Cognetta, M. Gromeier, M. A. Selim, D. D. Bigner, R. McLendon, and M. J. Whitley. “Expression of CD155, PD-1 and PD-L1 in Non-Melanoma Skin Cancer: Implications for Treatment of Advanced Disease.” In Annals of Surgical Oncology, 27:S204–S204. SPRINGER, 2020.
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  - Landa, K., V. Chandramohan, M. Gonen, J. M. Winter, M. Lidsky, K. Shah, S. Zani, et al. “CD226 Expression is Associated with Increased Survival in Pancreatic Cancer.” In Annals of Surgical Oncology, 27:S128–S128. SPRINGER, 2020.
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  - Frazier, Victoria N., Eda Holl, Michael Brown, David Boczkowski, Karenia Landa, Shelley Hwang, Matthias Gromeier, and Smita K. Nair. “Oncolytic poliovirus immunotherapy for breast cancer.” In Journal of Immunology, Vol. 204, 2020.
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  - Hariharan, Seethalakshmi, Michelle Bowie, Janell Hostettler, Kristen Roso, Yiping He, Martin A. Roskoski, Casey Charbonneau, et al. “INTERPLAY BETWEEN IDH1 AND ATRX MUTATIONS GOVERN INNATE IMMUNE RESPONSES IN GLIOMAS.” In Neuro Oncology, 22:108–108, 2020.
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  - Mosaheb, Mubeen, Daniel Landi, Elena Dobrikova, Michael Brown, Yuanfan Yang, Jana Cable, Hideho Okada, et al. “GENETICALLY STABLE POLIOVIRUS VECTOR CARRYING H3.3K27M ANTIGEN FOR TREATMENT OF DIFFUSE MIDLINE GLIOMA BY INTRAMUSCULAR INJECTION.” In Neuro Oncology, 22:472–472, 2020.
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  - Yang, Yuanfan, Michael Brown, Matthias Gromeier, and Darell Bigner. “ONCOLYTIC POLIOVIRUS AS A PROBE FOR MECHANISMS OF IMMUNE RESISTANCE IN GLIOBLASTOMA.” In Neuro Oncology, 22:231–231, 2020.
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  - Bowie, Michelle, Seethalakshmi Hariharan, Janell Hostettler, Kristen Roso, Yiping He, Christopher Pirozzi, Martin Roskoski, et al. “ATRX MUTATIONS PREDICT RESPONSE TO INNATE BASED THERAPY IN GLIOMA.” In Neuro Oncology, 21:126–126. OXFORD UNIV PRESS INC, 2019.
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  - Gromeier, Matthias, Michael Brown, Nike Beuabier, Hai Yan, Yiping He, Gao Zhang, Annick Desjardins, et al. “TUMOR MUTATIONAL BURDEN PREDICTS RESPONSE TO ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) IN MALIGNANT GLIOMA PATIENTS: ASSESSMENT OF TRANSCRIPTIONAL AND IMMUNOLOGICAL CORRELATES.” In Neuro Oncology, 21:7–7. OXFORD UNIV PRESS INC, 2019.
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  - Gromeier, Matthias, Mubeen Mosaheb, Elena Dobrikova, Michael Brown, Darell Bigner, and David Ashley. “GENETICALLY STABLE POLIOVIRUS VECTOR PLATFORM FOR DIPG IMMUNOTHERAPY.” In Neuro Oncology, 21:93–93. OXFORD UNIV PRESS INC, 2019.
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  - Desjardins, Annick, Matthias Gromeier, James Emmett Herndon, Dina Randazzo, Stevie Threatt, Eric S. Lipp, Elizabeth S. Miller, et al. “Oncolytic polio/rhinovirus recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG): Experience with retreatment of survivors from the phase I trial.” In Journal of Clinical Oncology, 37:101s-101s. American Society of Clinical Oncology (ASCO), 2019. https://doi.org/10.1200/JCO.2019.37.15_suppl.2060.
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  - Ashley, David, Annick Desjardins, Matthias Gromeier, Andrea Muscat, James Herndon, Allan Friedman, Henry Friedman, et al. “INTRATUMORAL ADMINISTRATION OF AN ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) IN MALIGNANT GLIOMA PATIENTS: ASSESSMENT OF MUTATIONAL RESPONSE CORRELATES.” In Neuro Oncology, 20:7–7. OXFORD UNIV PRESS INC, 2018.
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  - Bowie, Michelle, David Ashley, Janell Hostettler, Michael Brown, Jeffrey Bryant, Darell Bigner, Matthias Gromeier, and Smita Nair. “DYSFUNCTIONAL STING PATHWAY SIGNALING COMPROMISES INNATE IMMUNITY IN GLIOBLASTOMA.” In Neuro Oncology, 20:127–28. OXFORD UNIV PRESS INC, 2018.
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  - Thompson, Eric, Michael Brown, Elena Dobrikova, Vijay Ramaswamy, Michael Taylor, Roger McLendon, Vidya Chandramohan, Darell Bigner, and Matthias Gromeier. “POLIOVIRUS RECEPTOR (CD155) EXPRESSION IN PEDIATRIC BRAIN TUMORS MEDIATES ONCOLYSIS OF MEDULLOBLASTOMA AND PLEOMORPHIC XANTHOASTROCYTOMA.” In Neuro Oncology, 20:213–213. OXFORD UNIV PRESS INC, 2018.
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  - Brown, Michael C., Eda K. Holl, David Boczkowski, Elena Dobrikova, Mubeen Mosaheb, Vidya Chandramohan, Darell D. Bigner, Matthias Gromeier, and Smita K. Nair. “Abstract A79: Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of antigen-presenting cells and tumor antigen-specific CTLs.” In Cancer Immunology Research, 6:A79–A79. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/2326-6074.tumimm17-a79.
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  - Landa, Karenia, Eda Holl, Michael Brown, James Herndon, Lars Grimm, Jeremy Force, Darell Bigner, Shelley Hwang, Matthias Gromeier, and Smita Nair. “Abstract LB-302: Oncolytic poliovirus-mediated inflammation and immunity in breast cancer.” In Cancer Research, Vol. 78. American Association for Cancer Research (AACR), 2018. https://doi.org/10.1158/1538-7445.am2018-lb-302.
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  - Ashley, David M., Eric M. Thompson, Daniel Landi, Annick Desjardins, Allan H. Friedman, Stevie Threatt, James E. Herndon, et al. “PHASE 1B STUDY POLIO VACCINE SABIN-RHINOVIRUS POLIOVIRUS (PVSRIPO) FOR RECURRENT MALIGNANT GLIOMA IN CHILDREN.” In Neuro Oncology, 20:93–93. OXFORD UNIV PRESS INC, 2018.
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  - Force, Jeremy, Eda Holl, Michael Brown, Paul Kelly Marcom, Lars Grimm, David Boczkowski, Victoria Frazier, et al. “Recombinant oncolytic poliovirus combined with checkpoint blockade for breast cancer therapy.” In Journal of Clinical Oncology, 36:e12641–e12641. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.e12641.
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  - Bryant, Jeffrey, Michael Brown, and Matthias Gromeier. “Chemotherapy enhances oncolytic recombinant poliovirus efficacy.” In Journal for Immunotherapy of Cancer, Vol. 5. BMC, 2017.
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  - Walton, Ross, Michael Brown, Eda Holl, David Boczkowski, Vidya Chandramohan, Smita Nair, and Matthias Gromeier. “PVSRIPO is an interferon-resistant, immunotherapeutic oncolytic virus.” In Journal for Immunotherapy of Cancer, Vol. 5. BMC, 2017.
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  - Desjardins, Annick, John H. Sampson, Gordana Vlahovic, Katherine B. Peters, Dina Randazzo, Stevie Threatt, James Emmett Herndon, et al. “Dose finding study of the intratumoral administration of the oncolytic polio/rhinovirus recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG).” In Journal of Clinical Oncology, 35:e13533–e13533. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.e13533.
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  - Holl, E., M. Brown, D. Boczkowski, D. Bigner, M. Gromeier, and S. Nair. “POLIO VIRUS THERAPY HAS IMMUNOSTIMULATORY PROPERTIES THAT ARE ACTIVE AGAINST SOLID TUMORS.” In Cytokine, 87:61–62. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2016.
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  - Mosaheb, M Mubeen, Elena Dobrikova, Michael C. Brown, Christopher Pirozzi, Vidyalakshmi Chandramohan, Eda Holl, Smita Nair, and Matthias Gromeier. “Abstract A032: Using oncolytic polio expressing tumor as a cancer vaccine.” In Cancer Immunology Research, 4:A032–A032. American Association for Cancer Research (AACR), 2016. https://doi.org/10.1158/2326-6066.imm2016-a032.
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  - Desjardins, Annick, John H. Sampson, Katherine B. Peters, Gordana Vlahovic, Dina Randazzo, Stevie Threatt, James Emmett Herndon, et al. “Patient survival on the dose escalation phase of the Oncolytic Polio/Rhinovirus Recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG) clinical trial compared to historical controls.” In Journal of Clinical Oncology, 34:2061–2061. American Society of Clinical Oncology (ASCO), 2016. https://doi.org/10.1200/jco.2016.34.15_suppl.2061.
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  - Desjardins, Annick, John H. Sampson, Katherine B. Peters, Gordana Vlahovic, Dina Randazzo, Stevie Threatt, James Emmett Herndon, et al. “Oncolytic polio/rhinovirus recombinant (PVSRIPO) against recurrent glioblastoma (GBM): Optimal dose determination.” In Journal of Clinical Oncology, 33:2068–2068. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.2068.
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  - Desjardins, Annick, John Howard Sampson, Katherine B. Peters, Tulika Ranjan, Gordana Vlahovic, Jason Watts, Stevie Threatt, et al. “Phase I study of the intratumoral administration of an oncolytic polio/rhinovirus recombinant (PVSRIPO) in recurrent glioblastoma (GBM).” In Journal of Clinical Oncology, 32:TPS2106–TPS2106. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps2106.
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  - Desjardins, Annick, J. H. Sampson, K. B. Peters, T. Ranjan, G. Vlahovic, S. Threatt, J. E. Herndon, et al. “Intratumoral administration of an Oncolytic Polio/Rhinovirus Recombinant (PVSRIPO) in recurrent glioblastoma(GBM): Preliminary results of the Phase I clinical trial.” In Cancer Research, Vol. 74, 2014. https://doi.org/10.1158/1538-7445.AM2014-CT416.
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  - Barton, Kelly, Katie Misuraca, Francisco Cordero, Elena Dobrikova, Hooney Min, Matthias Gromeier, David Kirsch, and Oren Becher. “PD-0332991, A CDK4/6 INHIBITOR, SIGNIFICANTLY PROLONGS SURVIVAL IN A GENETICALLY ENGINEERED MOUSE MODEL OF BRAINSTEM GLIOMA.” In Neuro Oncology, 15:38–38. OXFORD UNIV PRESS INC, 2013.
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  - Desjardins, Annick, John Sampson, Katherine Peters, Tulika Ranjan, Gordana Vlahovic, Stevie Threatt, James Herndon, et al. “PHASE 1 STUDY OF AN ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) AGAINST RECURRENT GLIOBLASTOMA.” In Neuro Oncology, 15:107–8. OXFORD UNIV PRESS INC, 2013.
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  - Desjardins, Annick, John Howard Sampson, Katherine B. Peters, Tulika Ranjan, Gordana Vlahovic, Stevie Threatt, James Emmett Herndon, et al. “Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma.” In Journal of Clinical Oncology, Vol. 31. AMER SOC CLINICAL ONCOLOGY, 2013.
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  - Gromeier, Matthias, Annick Desjardins, John H. Sampson, Stevie J. E. Threatt, James E. Herndon, Allan Friedman, Henry S. Friedman, and Darell D. Bigner. “ONCOLYTIC POLIOVIRUS IMMUNOTHERAPY OF PRIMARY CNS TUMORS.” In Neuro Oncology, 15:20–20. OXFORD UNIV PRESS INC, 2013.
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  - Desjardins, Annick, John Howard Sampson, Katherine B. Peters, Tulika Ranjan, Gordana Vlahovic, Stevie Threatt, James Emmett Herndon, et al. “Dose-finding and safety study of an oncolytic polio/rhinovirus recombinant against recurrent glioblastoma.” In Journal of Clinical Oncology, Vol. 31, 2013.
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  - Gromeier, M., E. Y. Dobrikova, M. K. Merrill, S. A. Moore, C. Kaiser, R. Grisham, and L. Selznick. “Non-pathogenic poliovirus recombinants for the treatment of malignant glioma.” In Neuro Oncology, 7:382–382. DUKE UNIV PRESS, 2005.
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  - Cello, J., N. De Jesus, K. Chumakov, J. Yin, A. V. Paul, M. Gromeier, and E. Wimmer. “A new polio vaccine?” In Vaccines: Preventing Disease and Protecting Health, edited by C. A. DeQuadros, 183–88. PAN AMERICAN HEALTH ORGANIZATION, 2004.
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  - Merrill, M., E. Dobrikova, and M. Gromeier. “Oncolytic poliovirus recombinants for the treatment of malignant glioma.” In Gene Therapy, 8:S4–S4. NATURE PUBLISHING GROUP, 2001.
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  - Gromeier, M., L. Alexander, and E. Wimmer. “Substitution of the poliovirus IRES with its counterpart from human rhinovirus type 2 mediates loss of neurovirulence.” In Vaccines 96 Molecular Approaches to the Control of Infectious Diseases, edited by F. Brown, E. Norrby, D. Burton, and J. Mekalanos, 19–25. COLD SPRING HARBOR LABORATORY PRESS, 1996.
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  - LU, H. H., L. ALEXANDER, M. GROMEIER, and E. WIMMER. “DICISTRONIC POLIOVIRUSES EXPRESSING THE ANTIGENIC DETERMINANTS FROM GP120 OF HIV-1.” In Vaccines 94 Modern Approaches to New Vaccines Including Prevention of Aids, edited by E. Norrby, F. Brown, R. M. Chanock, and H. S. Ginsberg, 161–67. COLD SPRING HARBOR LABORATORY PRESS, 1994.
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  - WIMMER, E., J. J. HARBER, J. A. BIBB, M. GROMEIER, H. H. LU, and G. BERNHARDT. “POLIOVIRUS RECEPTORS.” In Cellular Receptors for Animal Viruses, edited by E. Wimmer, 101–27. COLD SPRING HARBOR LABORATORY PRESS, 1994.
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  - Desjardins, Annick, John Sampson, Katherine Peters, Gordana Vlahoci, Dina Randazzo, Stevie Threatt, James Herndon, et al. “Oncolytic polio/rhinovirus recombinant (PVSRIPO) against recurrent glioblastoma (GBM): Optimal dose determination.,” 33:112s-112s, n.d.
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- Preprints
  - Yang, Yuanfan, Michael Brown, Gao Zhang, Kevin Stevenson, Malte Mohme, Reb Kornahrens, Darell Bigner, David Ashley, Giselle López, and Matthias Gromeier. “Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation.” BioRxiv, 2022. https://doi.org/10.1101/2022.04.19.488771.
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Teaching & Mentoring
Recent Courses
- MGM 293: Research Independent Study I 2023
- MGM 593: Research Independent Study 2022
- PHARM 394: Research Independent Study 2022
- MGM 293: Research Independent Study I 2021
- MGM 593: Research Independent Study 2021
- PHARM 394: Research Independent Study 2021
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Academic & Administrative Activities
- 2000-2005 Molecular Genetics & Microbiology Graduate Student Admissions Committee
  
  2002 Graduate School Medical Ethics Retreat, Beaufort
  
  2002 Institutional Review Committee; American Cancer Society IRG
  
  2002-2004             MGM/CMB/Cell Biology/Biochemistry Seminar Committee (The Thursday Series)
  
  2002-2003             Dept. of Molecular Genetics & Microbiology Faculty Search Committees
  
  2002-2010             Director, 3^rdYear Medical School Cancer Biology Program (CBP)
  
  2003-2005             Dept. of Molecular Genetics & Microbiology Faculty Search Committees
  
  2004-                     Basic Sciences Faculty Steering Committee
  
  2004-                     Molecular Cancer Biology Graduate Student Program, Prelim Committee
  
  2005 Medical Sciences Training Program (MSTP) Admissions Committee
  
  2005-2006             Academic Council
  
  2012-2013             Faculty Mentoring/Path to Independence
  
  2016-                     Vice Chair for Research, Dept. of Neurosurgery
Clinical Activities
- N/A

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