Research Interests
Cancer Immunotherapy
Translation Control
+ssRNA Viruses
Poliovirus
Innate Immunology
Brain Tumors
Translation Control
+ssRNA Viruses
Poliovirus
Innate Immunology
Brain Tumors
Selected Grants
Duke Research Training Program in Surgical Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Innate Antiviral Signals for Cancer Immunotherapy
ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2018 - 2028Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2023 - 2028ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM
ResearchAdvisor · Awarded by National Cancer Institute · 2022 - 2027Duke Research Training Program in Surgical Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Innate Antiviral Signals for Cancer Immunotherapy
ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2018 - 2028Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2023 - 2028ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas
ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM
ResearchAdvisor · Awarded by National Cancer Institute · 2022 - 2027Randomized Phase 2 (Ph2) clinical trial of Lerapolturev (previously known as PVSRIPO) in recurrent glioblastoma (rGBM)
Clinical TrialPrincipal Investigator · Awarded by Brain Tumor Research Charity · 2024 - 2027Nervous system control and regulation of the immune system following neurological insults
ResearchEvaluator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2026Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026Targeting Interferon Signaling in Macrophages for Cancer Immunotherapy
FellowshipPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2023 - 2025Pharmacological Sciences Training Grant
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025PVSRIPO in melanoma
ResearchCo-Mentor · Awarded by National Cancer Institute · 2020 - 2025Viral Oncology Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1980 - 2025Regional Oncolytic Poliovirus Immunotherapy for Breast Cancer
ResearchCo Investigator · Awarded by Department of Defense · 2016 - 2024Identifying oncolytic viral therapy resistance mechanisms in brain tumors
ResearchInvestigator · Awarded by American Brain Tumor Association · 2021 - 2022T32 UNC - Duke Immunotherapy Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by University of North Carolina - Chapel Hill · 2021 - 2022Translational Research in Surgical Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2022The Role of CD155 in Leptomeningeal Dissemination and Oncolytic Virus Susceptibility in the Medulloblastoma Microenvironment
ResearchMentor · Awarded by Department of Defense · 2018 - 2022Oncolytic Polovirus, Immunotoxin, and Checkpoint Inhibitor Therapy of Gliomas
ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2022Understanding the Mechanism of Type-I/III Interferon Dominant Inflammation Induced by PVSRIPO Immunotherapy
ResearchPrincipal Investigator · Awarded by Brain Tumor Research Charity · 2021 - 2022Establishing a Rationale for PVSRIPO Immunotherapy in Newly Diagnosed GBM
ResearchPrincipal Investigator · Awarded by National Brain Tumor Society · 2019 - 2022Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma?
ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2022Phase-1 clinical trial of PVSRIPO oncolytic immunotherapy in pediatric HGG
Clinical TrialPD/PI · Awarded by Solving Kids' Cancer · 2016 - 2021Poliovirus-Instigated APC Responses Against BRaf(V600E) for Pediatric Brain Tumor Immunotherapy
ResearchCo Investigator · Awarded by V Foundation for Cancer Research · 2018 - 2021Cancer Immunotherapy Through Intratumoral Activation of Recall Responses
FellowshipPrincipal Investigator · Awarded by National Cancer Center · 2017 - 2019Oncolytic Immunotherapy of Glioblastoma with Recombinant Poliovirus
ResearchPrincipal Investigator · Awarded by Blast Glioblastoma · 2015 - 2019Combining PVSRIPO Immunotherapy with Lomustine for the Treatment of Recurrent GBM
ResearchPrincipal Investigator · Awarded by National Brain Tumor Society · 2017 - 2019Recombinant Attenuated Poliovirus Immunization Vectors Targeting H3.3(K27M) in DIPG
ResearchCo Investigator · Awarded by Michael Mosier Defeat DIPG Foundation · 2018 - 2019Targeting Translation Control in Malignant Glioma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2018Oncolytic PVSRIPO Expressing Tumor Antigens as a Cancer Vaccine
ResearchPrincipal Investigator · Awarded by Oligo Nation · 2016 - 2017Research Training In Neuro-Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016Phase II/III Manufacture of the Oncolytic Poliovirus Chimera, PVSRIPO
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2015 - 2016Oncolytic Poliovirus Immunotherapy of Malignant Glioma
ResearchCo Investigator · Awarded by The Slomo and Cindy Silvian Foundation, Inc · 2014 - 2015Oncolytic Virotherapy of Meningeal Cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2015Oncolytic poliovirus therapy of malignant glioma
ResearchPrincipal Investigator · Awarded by Southeastern Brain Tumor Foundation · 2014 - 2015Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2012Transgenic Mouse Model for the Common Cold
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2010Research Training In Neuro-Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010Cis and Trans-acting Factors in HCV Gene Expression
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2008Cell Type-Specific Viral Translation in the CNS
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007TARGETING BREAST CANCER CNS METASTASIS WITH ONCOLYTIC POLIOVIRUSES Targeted Breast Cancer CNS Metastasis with Oncolytic Polioviruses
ResearchPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2004 - 2005Cell Type-Specific Viral Translation in the CNS
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2005Genetically stable Picornavirus HIV Immunization vectors
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2005Production of non-pathogenic oncolytic poliovirus chimeras for the treatment of brain tumors (Project #417)
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2002Production of non-pathogenic oncolytic poliovirus chimeras for the treatment of brain tumors
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2001External Relationships
- Istari Oncology Inc.
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.