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Matthias Gromeier

Cless Family Distinguished Professor in Neuro-Oncology
Neurosurgery, Neuro-Oncology
Box 3020 Med Ctr, Durham, NC 27710
Research Drive, Rm 423, MSRB1, Durham, NC 27710
Office hours N/A  

Research Interests


Cancer Immunotherapy
Translation Control
+ssRNA Viruses
Poliovirus
Innate Immunology
Brain Tumors

Selected Grants


Duke Research Training Program in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 2024 - 2029

Innate Antiviral Signals for Cancer Immunotherapy

ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2018 - 2028

Resolving Spatiotemporal Dynamics of Recombinant Poliovirus Immunotherapy

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2023 - 2028

Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM

ResearchAdvisor · Awarded by National Cancer Institute · 2022 - 2027

ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas

ResearchCollaborator · Awarded by National Cancer Institute · 2022 - 2027

Randomized Phase 2 (Ph2) clinical trial of Lerapolturev (previously known as PVSRIPO) in recurrent glioblastoma (rGBM)

Clinical TrialPrincipal Investigator · Awarded by Brain Tumor Research Charity · 2024 - 2027

Nervous system control and regulation of the immune system following neurological insults

ResearchEvaluator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2026

Cell and Molecular Biology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2021 - 2026

Targeting Interferon Signaling in Macrophages for Cancer Immunotherapy

FellowshipPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2023 - 2025

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

PVSRIPO in melanoma

ResearchCo-Mentor · Awarded by National Cancer Institute · 2020 - 2025

Viral Oncology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1980 - 2025

Regional Oncolytic Poliovirus Immunotherapy for Breast Cancer

ResearchCo Investigator · Awarded by Department of Defense · 2016 - 2024

Identifying oncolytic viral therapy resistance mechanisms in brain tumors

ResearchInvestigator · Awarded by American Brain Tumor Association · 2021 - 2022

T32 UNC - Duke Immunotherapy Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by University of North Carolina - Chapel Hill · 2021 - 2022

Translational Research in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2002 - 2022

Oncolytic Polovirus, Immunotoxin, and Checkpoint Inhibitor Therapy of Gliomas

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2022

Understanding the Mechanism of Type-I/III Interferon Dominant Inflammation Induced by PVSRIPO Immunotherapy

ResearchPrincipal Investigator · Awarded by Brain Tumor Research Charity · 2021 - 2022

Establishing a Rationale for PVSRIPO Immunotherapy in Newly Diagnosed GBM

ResearchPrincipal Investigator · Awarded by National Brain Tumor Society · 2019 - 2022

Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma?

ResearchCollaborator · Awarded by National Institutes of Health · 2019 - 2022

Phase-1 clinical trial of PVSRIPO oncolytic immunotherapy in pediatric HGG

Clinical TrialPD/PI · Awarded by Solving Kids' Cancer · 2016 - 2021

Poliovirus-Instigated APC Responses Against BRaf(V600E) for Pediatric Brain Tumor Immunotherapy

ResearchCo Investigator · Awarded by V Foundation for Cancer Research · 2018 - 2021

Organization and Function of Cellular Structure

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2020

Cancer Immunotherapy Through Intratumoral Activation of Recall Responses

FellowshipPrincipal Investigator · Awarded by National Cancer Center · 2017 - 2019

Oncolytic Immunotherapy of Glioblastoma with Recombinant Poliovirus

ResearchPrincipal Investigator · Awarded by Blast Glioblastoma · 2015 - 2019

Combining PVSRIPO Immunotherapy with Lomustine for the Treatment of Recurrent GBM

ResearchPrincipal Investigator · Awarded by National Brain Tumor Society · 2017 - 2019

Recombinant Attenuated Poliovirus Immunization Vectors Targeting H3.3(K27M) in DIPG

ResearchCo Investigator · Awarded by Michael Mosier Defeat DIPG Foundation · 2018 - 2019

Targeting Translation Control in Malignant Glioma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2018

Oncolytic PVSRIPO Expressing Tumor Antigens as a Cancer Vaccine

ResearchPrincipal Investigator · Awarded by Oligo Nation · 2016 - 2017

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1998 - 2016

Phase II/III Manufacture of the Oncolytic Poliovirus Chimera, PVSRIPO

ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2015 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016

Oncolytic Poliovirus Immunotherapy of Malignant Glioma

ResearchCo Investigator · Awarded by The Slomo and Cindy Silvian Foundation, Inc · 2014 - 2015

Oncolytic Virotherapy of Meningeal Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2015

Instrumentation for Quantitative Phosphoproteomics and Acetylomics

EquipmentMajor User · Awarded by National Institutes of Health · 2014 - 2015

Oncolytic poliovirus therapy of malignant glioma

ResearchPrincipal Investigator · Awarded by Southeastern Brain Tumor Foundation · 2014 - 2015

Enterovirus Vectors with Respiratory Tropism for Cancer Immunotherapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2012

Transgenic Mouse Model for the Common Cold

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2010

Research Training In Neuro-Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2005 - 2010

Cis and Trans-acting Factors in HCV Gene Expression

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2008

Cell Type-Specific Viral Translation in the CNS

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007

TARGETING BREAST CANCER CNS METASTASIS WITH ONCOLYTIC POLIOVIRUSES Targeted Breast Cancer CNS Metastasis with Oncolytic Polioviruses

ResearchPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2004 - 2005

Cell Type-Specific Viral Translation in the CNS

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2005

Genetically stable Picornavirus HIV Immunization vectors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2005

Production of non-pathogenic oncolytic poliovirus chimeras for the treatment of brain tumors (Project #417)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2002

Production of non-pathogenic oncolytic poliovirus chimeras for the treatment of brain tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2001