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Carl F. Pieper

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Duke Box 3003, Durham, NC 27710
1513 Busse Bldg, Durham, NC 27710

Overview


Analytic Interests.

1) Issues in the Design of Medical Experiments: I explore the use of reliability/generalizability models in experimental design. In addition to incorporation of reliability, I study powering longitudinal trials with multiple outcomes and substantial missing data using Mixed models.

2) Issues in the Analysis of Repeated Measures Designs & Longitudinal Data: Use of Hierarchical Linear Models (HLM) or Mixed Models in modeling trajectories of multiple variables over time (e.g., physical and cognitive functioning and Blood Pressure). My current work involves methodologies in simultaneous estimation of trajectories for multiple variables within and between domains, modeling co-occuring change.

Areas of Substantive interest: (1) Experimental design and analysis in gerontology and geriatrics, and psychiatry,
(2) Multivariate repeated measures designs,

Current Appointments & Affiliations


Professor of Biostatistics & Bioinformatics · 2022 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics

In the News


Published January 8, 2024
Study of Duke Heart Attack Patients Finds Definitive Benefit of Cardiac Rehab
Published September 7, 2023
Concussions May Cause Cognitive Declines Later in Life

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Recent Publications


Longitudinal Analysis of Cardiovascular Risk Factors Among Older Adults Participating in a Park-Based Fitness Program.

Journal Article Int J Aging Hum Dev · March 2026 Background: Physical inactivity is a major risk factor for noncommunicable diseases, particularly among older adults. We examined changes in cardiovascular risk factors among older adults in a community-based fitness program in Miami-Dade County, FL. Metho ... Full text Link to item Cite

Grief Among Oncology Providers: Prevalence and Association with Burnout.

Journal Article J Cancer Educ · December 2025 International research shows that oncology providers frequently experience grief and that grief is linked to burnout. Evidence on the prevalence of grief and its link to burnout is limited, especially in the United States (US). We investigated the prevalen ... Full text Link to item Cite

Development of a physical performance summary score in middle age: Findings from the CARDIA Function study.

Conference Am J Epidemiol · October 7, 2025 Few physical performance batteries exist that appropriately evaluate physical limitations in middle-aged adults. We aimed to develop a physical performance summary score that is appropriate for use in epidemiology studies of middle-aged adults using data f ... Full text Link to item Cite
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Recent Grants


2/3 CTSA K12 Program at Duke University

ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030

Measuring Racial Equity and Institutional Racism in Primary Care (EQUIP)

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2028

Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging

ResearchCo Investigator · Awarded by Tufts Medical Center · 2022 - 2027

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Education, Training & Certifications


Columbia University · 1990 DrPH