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Sean Michael O'Brien

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
Duke Box 3850, Durham, NC 27710
200 Morris Street, 7816 200 Morris, Durham, NC 27701

Overview


Statistical methods for healthcare provider profiling; observational studies; Bayesian data analysis.

Current Appointments & Affiliations


Associate Professor of Biostatistics & Bioinformatics · 2014 - Present Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics
Member in the Duke Clinical Research Institute · 2004 - Present Duke Clinical Research Institute, Institutes and Centers

Recent Publications


Use of coronary artery bypass graft surgery and percutaneous coronary intervention and associated outcomes in the ISCHEMIA trial.

Journal Article Am Heart J · November 2025 BACKGROUND: In the ISCHEMIA Trial, 5,179 patients with stable coronary disease were randomized to initial invasive or conservative management. METHODS: PCI was recommended with a SYNTAX score 0 to 22 (low) and CABG with a SYNTAX score ≥33 (high). Either co ... Full text Link to item Cite

Health Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA.

Journal Article Circulation · September 23, 2025 BACKGROUND: In ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches), an invasive strategy demonstrated better health status outcomes than a conservative strategy in patients with chronic coronary disease ( ... Full text Link to item Cite

Comparative Prognosis by Stress ECG and Stress Imaging: Results From the ISCHEMIA Trial.

Journal Article JACC Cardiovasc Imaging · September 2025 BACKGROUND: Limited contemporary evidence exists on risk prediction by stress imaging and exercise electrocardiography (ECG) among patients with chronic coronary syndromes (CCS). Objectives From the ISCHEMIA (International Study of Comparative Health Effec ... Full text Link to item Cite
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Recent Grants


iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2025 - 2030

2/2 IMPRroving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2030

Integrated Biostatistical Training for CVD Research

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by North Carolina State University · 2022 - 2027

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 2002 Ph.D.