Mismatch repair gone awry: Management of Lynch syndrome.

Journal Article (Journal Article;Review)

The hallmark of Lynch syndrome involves germline mutations of genes important in DNA mismatch repair. Affected family kindreds will have multiple associated malignancies, the most common of which is colorectal adenocarcinoma. Recently, evidence has shown that clinical diagnostic criteria provided by the Amsterdam Criteria and the Bethesda Guidelines must be linked with microsatellite instability testing to correctly diagnose Lynch syndrome. We present a case of metachronous colorectal adenocarcinomas in a patient less than 50 years of age, followed by a discussion of Lynch syndrome, with an emphasis on surveillance and prevention of malignancies.

Full Text

Duke Authors

Cited Authors

  • Zhang, T; Boswell, EL; McCall, SJ; Hsu, DS

Published Date

  • March 2015

Published In

Volume / Issue

  • 93 / 3

Start / End Page

  • 170 - 179

PubMed ID

  • 25459670

Electronic International Standard Serial Number (EISSN)

  • 1879-0461

Digital Object Identifier (DOI)

  • 10.1016/j.critrevonc.2014.10.005


  • eng

Conference Location

  • Netherlands