Mismatch repair gone awry: Management of Lynch syndrome.
Publication
, Journal Article
Zhang, T; Boswell, EL; McCall, SJ; Hsu, DS
Published in: Crit Rev Oncol Hematol
March 2015
The hallmark of Lynch syndrome involves germline mutations of genes important in DNA mismatch repair. Affected family kindreds will have multiple associated malignancies, the most common of which is colorectal adenocarcinoma. Recently, evidence has shown that clinical diagnostic criteria provided by the Amsterdam Criteria and the Bethesda Guidelines must be linked with microsatellite instability testing to correctly diagnose Lynch syndrome. We present a case of metachronous colorectal adenocarcinomas in a patient less than 50 years of age, followed by a discussion of Lynch syndrome, with an emphasis on surveillance and prevention of malignancies.
Duke Scholars
Published In
Crit Rev Oncol Hematol
DOI
EISSN
1879-0461
Publication Date
March 2015
Volume
93
Issue
3
Start / End Page
170 / 179
Location
Netherlands
Related Subject Headings
- Oncology & Carcinogenesis
- Mutation
- Middle Aged
- Male
- Intestinal Mucosa
- Humans
- Disease Management
- DNA Mismatch Repair
- Colorectal Neoplasms, Hereditary Nonpolyposis
- 3211 Oncology and carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, T., Boswell, E. L., McCall, S. J., & Hsu, D. S. (2015). Mismatch repair gone awry: Management of Lynch syndrome. Crit Rev Oncol Hematol, 93(3), 170–179. https://doi.org/10.1016/j.critrevonc.2014.10.005
Zhang, Tian, Elizabeth L. Boswell, Shannon J. McCall, and David S. Hsu. “Mismatch repair gone awry: Management of Lynch syndrome.” Crit Rev Oncol Hematol 93, no. 3 (March 2015): 170–79. https://doi.org/10.1016/j.critrevonc.2014.10.005.
Zhang T, Boswell EL, McCall SJ, Hsu DS. Mismatch repair gone awry: Management of Lynch syndrome. Crit Rev Oncol Hematol. 2015 Mar;93(3):170–9.
Zhang, Tian, et al. “Mismatch repair gone awry: Management of Lynch syndrome.” Crit Rev Oncol Hematol, vol. 93, no. 3, Mar. 2015, pp. 170–79. Pubmed, doi:10.1016/j.critrevonc.2014.10.005.
Zhang T, Boswell EL, McCall SJ, Hsu DS. Mismatch repair gone awry: Management of Lynch syndrome. Crit Rev Oncol Hematol. 2015 Mar;93(3):170–179.
Published In
Crit Rev Oncol Hematol
DOI
EISSN
1879-0461
Publication Date
March 2015
Volume
93
Issue
3
Start / End Page
170 / 179
Location
Netherlands
Related Subject Headings
- Oncology & Carcinogenesis
- Mutation
- Middle Aged
- Male
- Intestinal Mucosa
- Humans
- Disease Management
- DNA Mismatch Repair
- Colorectal Neoplasms, Hereditary Nonpolyposis
- 3211 Oncology and carcinogenesis