Overcoming Chronic Rejection-Can it B?


Journal Article (Review)

Despite the success of immunosuppressive drug therapy to reduce the incidence of acute rejection in organ transplantation, chronic rejection is still an impediment to long-term graft survival and tolerance. There is a growing body of evidence that B-cell production of alloantibody is an important element in the genesis of chronic rejection. Effector function of B cells in transplantation is not specifically targeted by current T-cell-directed therapeutic approaches. We briefly discuss the origin, animal models, diagnostic methods, and currently available B cell reagents that might be used in combination with existing immunosuppressive regimens to address B-cell-mediated allograft injury.

Full Text

Duke Authors

Cited Authors

  • Kwun, J; Knechtle, SJ

Published Date

  • October 27, 2009

Published In

Volume / Issue

  • 88 / 8

Start / End Page

  • 955 - 961

PubMed ID

  • 19855237

Pubmed Central ID

  • 19855237

Electronic International Standard Serial Number (EISSN)

  • 1534-6080

Digital Object Identifier (DOI)

  • 10.1097/TP.0b013e3181b96646


  • eng

Conference Location

  • United States