Overcoming Chronic Rejection-Can it B?
Publication
, Journal Article
Kwun, J; Knechtle, SJ
Published in: Transplantation
October 27, 2009
Despite the success of immunosuppressive drug therapy to reduce the incidence of acute rejection in organ transplantation, chronic rejection is still an impediment to long-term graft survival and tolerance. There is a growing body of evidence that B-cell production of alloantibody is an important element in the genesis of chronic rejection. Effector function of B cells in transplantation is not specifically targeted by current T-cell-directed therapeutic approaches. We briefly discuss the origin, animal models, diagnostic methods, and currently available B cell reagents that might be used in combination with existing immunosuppressive regimens to address B-cell-mediated allograft injury.
Duke Scholars
Published In
Transplantation
DOI
EISSN
1534-6080
Publication Date
October 27, 2009
Volume
88
Issue
8
Start / End Page
955 / 961
Location
United States
Related Subject Headings
- Tunica Intima
- Transplantation, Homologous
- T-Lymphocytes, Regulatory
- T-Lymphocytes
- Surgery
- Rodentia
- Muscle, Smooth, Vascular
- Mice
- Isoantibodies
- Inflammation
Citation
APA
Chicago
ICMJE
MLA
NLM
Kwun, J., & Knechtle, S. J. (2009). Overcoming Chronic Rejection-Can it B? Transplantation, 88(8), 955–961. https://doi.org/10.1097/TP.0b013e3181b96646
Kwun, Jean, and Stuart J. Knechtle. “Overcoming Chronic Rejection-Can it B?” Transplantation 88, no. 8 (October 27, 2009): 955–61. https://doi.org/10.1097/TP.0b013e3181b96646.
Kwun J, Knechtle SJ. Overcoming Chronic Rejection-Can it B? Transplantation. 2009 Oct 27;88(8):955–61.
Kwun, Jean, and Stuart J. Knechtle. “Overcoming Chronic Rejection-Can it B?” Transplantation, vol. 88, no. 8, Oct. 2009, pp. 955–61. Pubmed, doi:10.1097/TP.0b013e3181b96646.
Kwun J, Knechtle SJ. Overcoming Chronic Rejection-Can it B? Transplantation. 2009 Oct 27;88(8):955–961.
Published In
Transplantation
DOI
EISSN
1534-6080
Publication Date
October 27, 2009
Volume
88
Issue
8
Start / End Page
955 / 961
Location
United States
Related Subject Headings
- Tunica Intima
- Transplantation, Homologous
- T-Lymphocytes, Regulatory
- T-Lymphocytes
- Surgery
- Rodentia
- Muscle, Smooth, Vascular
- Mice
- Isoantibodies
- Inflammation