Overcoming Chronic Rejection-Can it B?

Journal Article (Journal Article;Review)

Despite the success of immunosuppressive drug therapy to reduce the incidence of acute rejection in organ transplantation, chronic rejection is still an impediment to long-term graft survival and tolerance. There is a growing body of evidence that B-cell production of alloantibody is an important element in the genesis of chronic rejection. Effector function of B cells in transplantation is not specifically targeted by current T-cell-directed therapeutic approaches. We briefly discuss the origin, animal models, diagnostic methods, and currently available B cell reagents that might be used in combination with existing immunosuppressive regimens to address B-cell-mediated allograft injury.

Full Text

Duke Authors

Cited Authors

  • Kwun, J; Knechtle, SJ

Published Date

  • October 27, 2009

Published In

Volume / Issue

  • 88 / 8

Start / End Page

  • 955 - 961

PubMed ID

  • 19855237

Electronic International Standard Serial Number (EISSN)

  • 1534-6080

Digital Object Identifier (DOI)

  • 10.1097/TP.0b013e3181b96646


  • eng

Conference Location

  • United States