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Overcoming Chronic Rejection-Can it B?

Publication ,  Journal Article
Kwun, J; Knechtle, SJ
Published in: Transplantation
October 27, 2009

Despite the success of immunosuppressive drug therapy to reduce the incidence of acute rejection in organ transplantation, chronic rejection is still an impediment to long-term graft survival and tolerance. There is a growing body of evidence that B-cell production of alloantibody is an important element in the genesis of chronic rejection. Effector function of B cells in transplantation is not specifically targeted by current T-cell-directed therapeutic approaches. We briefly discuss the origin, animal models, diagnostic methods, and currently available B cell reagents that might be used in combination with existing immunosuppressive regimens to address B-cell-mediated allograft injury.

Duke Scholars

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

October 27, 2009

Volume

88

Issue

8

Start / End Page

955 / 961

Location

United States

Related Subject Headings

  • Tunica Intima
  • Transplantation, Homologous
  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Surgery
  • Rodentia
  • Muscle, Smooth, Vascular
  • Mice
  • Isoantibodies
  • Inflammation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kwun, J., & Knechtle, S. J. (2009). Overcoming Chronic Rejection-Can it B? Transplantation, 88(8), 955–961. https://doi.org/10.1097/TP.0b013e3181b96646
Kwun, Jean, and Stuart J. Knechtle. “Overcoming Chronic Rejection-Can it B?Transplantation 88, no. 8 (October 27, 2009): 955–61. https://doi.org/10.1097/TP.0b013e3181b96646.
Kwun J, Knechtle SJ. Overcoming Chronic Rejection-Can it B? Transplantation. 2009 Oct 27;88(8):955–61.
Kwun, Jean, and Stuart J. Knechtle. “Overcoming Chronic Rejection-Can it B?Transplantation, vol. 88, no. 8, Oct. 2009, pp. 955–61. Pubmed, doi:10.1097/TP.0b013e3181b96646.
Kwun J, Knechtle SJ. Overcoming Chronic Rejection-Can it B? Transplantation. 2009 Oct 27;88(8):955–961.

Published In

Transplantation

DOI

EISSN

1534-6080

Publication Date

October 27, 2009

Volume

88

Issue

8

Start / End Page

955 / 961

Location

United States

Related Subject Headings

  • Tunica Intima
  • Transplantation, Homologous
  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Surgery
  • Rodentia
  • Muscle, Smooth, Vascular
  • Mice
  • Isoantibodies
  • Inflammation