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Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans.

Publication ,  Journal Article
Voils, CI; Coffman, CJ; Grubber, JM; Edelman, D; Sadeghpour, A; Maciejewski, ML; Bolton, J; Cho, A; Ginsburg, GS; Yancy, WS
Published in: J Gen Intern Med
November 2015

OBJECTIVE: We examined the clinical utility of supplementing type 2 diabetes mellitus (DM) risk counseling with DM genetic test results and counseling. RESEARCH DESIGN AND METHODS: In this randomized controlled trial, non-diabetic overweight/obese veteran outpatients aged 21 to 65 years received DM risk estimates for lifetime risk, family history, and fasting plasma glucose, followed by either genetic test results (CR+G; N = 303) or control eye disease counseling (CR+EYE; N = 298). All participants received brief lifestyle counseling encouraging weight loss to reduce the risk of DM. RESULTS: The mean age was 54 years, 53% of participants were black, and 80% were men. There was no difference between arms in weight (estimated mean difference between CR+G vs. CR+EYE at 3 months = 0.2 kg, 95% CI: -0.3 to 0.7; at 6 months = 0.4 kg, 95 % CI: -0.3 to 1.1), insulin resistance, perceived risk, or physical activity at 3 or 6 months. Calorie and fat intake were lower in the CR+G arm at 3 months (p's ≤ 0.05) but not at 6 months (p's > 0.20). CONCLUSIONS: Providing patients with genetic test results was not more effective in changing patient behavior to reduce the risk of DM compared to conventional risk counseling. TRIAL REGISTRATION: ClinicalTrials.gov NCT01060540 http://clinicaltrials.gov/show/NCT01060540.

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Published In

J Gen Intern Med

DOI

EISSN

1525-1497

Publication Date

November 2015

Volume

30

Issue

11

Start / End Page

1591 / 1598

Location

United States

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Veterans
  • Risk Reduction Behavior
  • Risk Factors
  • Overweight
  • Outcome Assessment, Health Care
  • Obesity
  • North Carolina
  • Middle Aged
 

Citation

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Voils, C. I., Coffman, C. J., Grubber, J. M., Edelman, D., Sadeghpour, A., Maciejewski, M. L., … Yancy, W. S. (2015). Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans. J Gen Intern Med, 30(11), 1591–1598. https://doi.org/10.1007/s11606-015-3315-5
Voils, Corrine I., Cynthia J. Coffman, Janet M. Grubber, David Edelman, Azita Sadeghpour, Matthew L. Maciejewski, Jamiyla Bolton, Alex Cho, Geoffrey S. Ginsburg, and William S. Yancy. “Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans.J Gen Intern Med 30, no. 11 (November 2015): 1591–98. https://doi.org/10.1007/s11606-015-3315-5.
Voils CI, Coffman CJ, Grubber JM, Edelman D, Sadeghpour A, Maciejewski ML, et al. Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans. J Gen Intern Med. 2015 Nov;30(11):1591–8.
Voils, Corrine I., et al. “Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans.J Gen Intern Med, vol. 30, no. 11, Nov. 2015, pp. 1591–98. Pubmed, doi:10.1007/s11606-015-3315-5.
Voils CI, Coffman CJ, Grubber JM, Edelman D, Sadeghpour A, Maciejewski ML, Bolton J, Cho A, Ginsburg GS, Yancy WS. Does Type 2 Diabetes Genetic Testing and Counseling Reduce Modifiable Risk Factors? A Randomized Controlled Trial of Veterans. J Gen Intern Med. 2015 Nov;30(11):1591–1598.
Journal cover image

Published In

J Gen Intern Med

DOI

EISSN

1525-1497

Publication Date

November 2015

Volume

30

Issue

11

Start / End Page

1591 / 1598

Location

United States

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Veterans
  • Risk Reduction Behavior
  • Risk Factors
  • Overweight
  • Outcome Assessment, Health Care
  • Obesity
  • North Carolina
  • Middle Aged