Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists.

Journal Article (Journal Article;Review)

Congestion is the most common reason for admissions and readmissions for heart failure (HF). The vast majority of hospitalized HF patients appear to respond readily to loop diuretics, but available data suggest that a significant proportion are being discharged with persistent evidence of congestion. Although novel therapies targeting congestion should continue to be developed, currently available agents may be utilized more optimally to facilitate complete decongestion. The combination of loop diuretics, natriuretic doses of mineralocorticoid receptor antagonists and vasopressin antagonists represents a regimen of currently available therapies that affects early and persistent decongestion, while limiting the associated risks of electrolyte disturbances, hemodynamic fluctuations, renal dysfunction and mortality.

Full Text

Duke Authors

Cited Authors

  • Vaduganathan, M; Mentz, RJ; Greene, SJ; Senni, M; Sato, N; Nodari, S; Butler, J; Gheorghiade, M

Published Date

  • 2015

Published In

Volume / Issue

  • 13 / 7

Start / End Page

  • 799 - 809

PubMed ID

  • 26106934

Electronic International Standard Serial Number (EISSN)

  • 1744-8344

Digital Object Identifier (DOI)

  • 10.1586/14779072.2015.1053872


  • eng

Conference Location

  • England