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Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists.

Publication ,  Journal Article
Vaduganathan, M; Mentz, RJ; Greene, SJ; Senni, M; Sato, N; Nodari, S; Butler, J; Gheorghiade, M
Published in: Expert Rev Cardiovasc Ther
2015

Congestion is the most common reason for admissions and readmissions for heart failure (HF). The vast majority of hospitalized HF patients appear to respond readily to loop diuretics, but available data suggest that a significant proportion are being discharged with persistent evidence of congestion. Although novel therapies targeting congestion should continue to be developed, currently available agents may be utilized more optimally to facilitate complete decongestion. The combination of loop diuretics, natriuretic doses of mineralocorticoid receptor antagonists and vasopressin antagonists represents a regimen of currently available therapies that affects early and persistent decongestion, while limiting the associated risks of electrolyte disturbances, hemodynamic fluctuations, renal dysfunction and mortality.

Duke Scholars

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

2015

Volume

13

Issue

7

Start / End Page

799 / 809

Location

England

Related Subject Headings

  • Mineralocorticoid Receptor Antagonists
  • Humans
  • Hospitalization
  • Heart Failure
  • Drug Therapy, Combination
  • Diuretics
  • Cardiovascular System & Hematology
  • Antidiuretic Hormone Receptor Antagonists
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
 

Citation

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Vaduganathan, M., Mentz, R. J., Greene, S. J., Senni, M., Sato, N., Nodari, S., … Gheorghiade, M. (2015). Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists. Expert Rev Cardiovasc Ther, 13(7), 799–809. https://doi.org/10.1586/14779072.2015.1053872
Vaduganathan, Muthiah, Robert J. Mentz, Stephen J. Greene, Michele Senni, Naoki Sato, Savina Nodari, Javed Butler, and Mihai Gheorghiade. “Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists.Expert Rev Cardiovasc Ther 13, no. 7 (2015): 799–809. https://doi.org/10.1586/14779072.2015.1053872.
Vaduganathan M, Mentz RJ, Greene SJ, Senni M, Sato N, Nodari S, et al. Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists. Expert Rev Cardiovasc Ther. 2015;13(7):799–809.
Vaduganathan, Muthiah, et al. “Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists.Expert Rev Cardiovasc Ther, vol. 13, no. 7, 2015, pp. 799–809. Pubmed, doi:10.1586/14779072.2015.1053872.
Vaduganathan M, Mentz RJ, Greene SJ, Senni M, Sato N, Nodari S, Butler J, Gheorghiade M. Combination decongestion therapy in hospitalized heart failure: loop diuretics, mineralocorticoid receptor antagonists and vasopressin antagonists. Expert Rev Cardiovasc Ther. 2015;13(7):799–809.
Journal cover image

Published In

Expert Rev Cardiovasc Ther

DOI

EISSN

1744-8344

Publication Date

2015

Volume

13

Issue

7

Start / End Page

799 / 809

Location

England

Related Subject Headings

  • Mineralocorticoid Receptor Antagonists
  • Humans
  • Hospitalization
  • Heart Failure
  • Drug Therapy, Combination
  • Diuretics
  • Cardiovascular System & Hematology
  • Antidiuretic Hormone Receptor Antagonists
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services