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A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer.

Publication ,  Journal Article
Gulack, BC; Yang, C-FJ; Speicher, PJ; Yerokun, BA; Tong, BC; Onaitis, MW; D'Amico, TA; Harpole, DH; Hartwig, MG; Berry, MF
Published in: Ann Thorac Surg
December 2016

BACKGROUND: The long-term survival benefit of lobectomy over sublobar resection for early-stage non-small cell lung cancer must be weighed against a potentially increased risk of perioperative mortality. The objective of the current study was to create a risk score to identify patients with favorable short-term outcomes following lobectomy. METHODS: The 2005-2012 American College of Surgeons National Surgical Quality Improvement Program database was queried for patients undergoing a lobectomy or sublobar resection (either segmentectomy or wedge resection) for lung cancer. A multivariable logistic regression model was utilized to determine factors associated with 30-day mortality among the lobectomy group and to develop an associated risk score to predict perioperative mortality. RESULTS: Of the 5,749 patients who met study criteria, 4,424 (77%) underwent lobectomy, 1,098 (19%) underwent wedge resection, and 227 (4%) underwent segmentectomy. Age, chronic obstructive pulmonary disease, previous cerebrovascular event, functional status, recent smoking status, and surgical approach (minimally invasive versus open) were utilized to develop the risk score. Patients with a risk score of 5 or lower had no significant difference in perioperative mortality by surgical procedure. Patients with a risk score greater than 5 had significantly higher perioperative mortality after lobectomy (4.9%) as compared to segmentectomy (3.6%) or wedge resection (0.8%, p < 0.01). CONCLUSIONS: In this study, we have developed a risk model that predicts relative operative mortality from a sublobar resection as compared to a lobectomy. Among patients with a risk score of 5 or less, lobectomy confers no additional perioperative risk over sublobar resection.

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Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

December 2016

Volume

102

Issue

6

Start / End Page

1814 / 1820

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Respiratory System
  • Pneumonectomy
  • Patient Selection
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Logistic Models
 

Citation

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Gulack, B. C., Yang, C.-F., Speicher, P. J., Yerokun, B. A., Tong, B. C., Onaitis, M. W., … Berry, M. F. (2016). A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer. Ann Thorac Surg, 102(6), 1814–1820. https://doi.org/10.1016/j.athoracsur.2016.06.032
Gulack, Brian C., Chi-Fu Jeffrey Yang, Paul J. Speicher, Babatunde A. Yerokun, Betty C. Tong, Mark W. Onaitis, Thomas A. D’Amico, David H. Harpole, Matthew G. Hartwig, and Mark F. Berry. “A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer.Ann Thorac Surg 102, no. 6 (December 2016): 1814–20. https://doi.org/10.1016/j.athoracsur.2016.06.032.
Gulack BC, Yang C-FJ, Speicher PJ, Yerokun BA, Tong BC, Onaitis MW, et al. A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer. Ann Thorac Surg. 2016 Dec;102(6):1814–20.
Gulack, Brian C., et al. “A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer.Ann Thorac Surg, vol. 102, no. 6, Dec. 2016, pp. 1814–20. Pubmed, doi:10.1016/j.athoracsur.2016.06.032.
Gulack BC, Yang C-FJ, Speicher PJ, Yerokun BA, Tong BC, Onaitis MW, D’Amico TA, Harpole DH, Hartwig MG, Berry MF. A Risk Score to Assist Selecting Lobectomy Versus Sublobar Resection for Early Stage Non-Small Cell Lung Cancer. Ann Thorac Surg. 2016 Dec;102(6):1814–1820.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

December 2016

Volume

102

Issue

6

Start / End Page

1814 / 1820

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Respiratory System
  • Pneumonectomy
  • Patient Selection
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Logistic Models