Simple Strategy for Taming Membrane-Disrupting Antibiotics.
Journal Article (Journal Article)
A strategy has been devised for increasing the cellular selectivity of membrane-disrupting antibiotics based on the attachment of a facially amphiphilic sterol. Using Amphotericin B (AmB) as a prototype, covalent attachment of cholic acid bound to a series of α,ω-diamines has led to a dramatic reduction in hemolytic activity, a significant reduction in toxicity toward HEK293T cells, and significant retention of antifungal activity.
- Yu, Y; Sabulski, MJ; Schell, WA; Pires, MM; Perfect, JR; Regen, SL
- December 21, 2016
Volume / Issue
- 27 / 12
Start / End Page
- 2850 - 2853
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States