Simple Strategy for Taming Membrane-Disrupting Antibiotics.
Publication
, Journal Article
Yu, Y; Sabulski, MJ; Schell, WA; Pires, MM; Perfect, JR; Regen, SL
Published in: Bioconjug Chem
December 21, 2016
A strategy has been devised for increasing the cellular selectivity of membrane-disrupting antibiotics based on the attachment of a facially amphiphilic sterol. Using Amphotericin B (AmB) as a prototype, covalent attachment of cholic acid bound to a series of α,ω-diamines has led to a dramatic reduction in hemolytic activity, a significant reduction in toxicity toward HEK293T cells, and significant retention of antifungal activity.
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Published In
Bioconjug Chem
DOI
EISSN
1520-4812
Publication Date
December 21, 2016
Volume
27
Issue
12
Start / End Page
2850 / 2853
Location
United States
Related Subject Headings
- Structure-Activity Relationship
- Organic Chemistry
- Microbial Sensitivity Tests
- Humans
- HEK293 Cells
- Cholic Acid
- Cell Membrane
- Candida
- Antifungal Agents
- Anti-Bacterial Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Yu, Y., Sabulski, M. J., Schell, W. A., Pires, M. M., Perfect, J. R., & Regen, S. L. (2016). Simple Strategy for Taming Membrane-Disrupting Antibiotics. Bioconjug Chem, 27(12), 2850–2853. https://doi.org/10.1021/acs.bioconjchem.6b00629
Yu, Yuming, Mary J. Sabulski, Wiley A. Schell, Marcos M. Pires, John R. Perfect, and Steven L. Regen. “Simple Strategy for Taming Membrane-Disrupting Antibiotics.” Bioconjug Chem 27, no. 12 (December 21, 2016): 2850–53. https://doi.org/10.1021/acs.bioconjchem.6b00629.
Yu Y, Sabulski MJ, Schell WA, Pires MM, Perfect JR, Regen SL. Simple Strategy for Taming Membrane-Disrupting Antibiotics. Bioconjug Chem. 2016 Dec 21;27(12):2850–3.
Yu, Yuming, et al. “Simple Strategy for Taming Membrane-Disrupting Antibiotics.” Bioconjug Chem, vol. 27, no. 12, Dec. 2016, pp. 2850–53. Pubmed, doi:10.1021/acs.bioconjchem.6b00629.
Yu Y, Sabulski MJ, Schell WA, Pires MM, Perfect JR, Regen SL. Simple Strategy for Taming Membrane-Disrupting Antibiotics. Bioconjug Chem. 2016 Dec 21;27(12):2850–2853.
Published In
Bioconjug Chem
DOI
EISSN
1520-4812
Publication Date
December 21, 2016
Volume
27
Issue
12
Start / End Page
2850 / 2853
Location
United States
Related Subject Headings
- Structure-Activity Relationship
- Organic Chemistry
- Microbial Sensitivity Tests
- Humans
- HEK293 Cells
- Cholic Acid
- Cell Membrane
- Candida
- Antifungal Agents
- Anti-Bacterial Agents