Respiratory Support for Very Low Birth Weight Infants Receiving Dexamethasone.

Journal Article (Journal Article)

OBJECTIVE: To assess how neonatal intensive care units followed the American Academy of Pediatrics guidelines for use of dexamethasone in preterm infants by evaluating respiratory support at the time of dexamethasone administration. STUDY DESIGN: This is an observational study of infants discharged from one of 290 neonatal intensive care units from 2003 to 2010. The cohort included very low birth weight (<1500 g birth weight) infants born at ≤32 weeks gestational age. The main outcome was respiratory support at time of exposure to dexamethasone. Significant respiratory support was defined as invasive respiratory support (conventional or high-frequency ventilation) with a fraction of inspired oxygen (FiO2) > 0.3. RESULTS: Of 81 292 infants; 7093 (9%) received dexamethasone. At the time that dexamethasone was initiated, 4604 (65%) of infants were on significant respiratory support. CONCLUSIONS: In accordance with the American Academy of Pediatrics recommendations, a majority of infants were on significant respiratory support when receiving dexamethasone, yet a substantial number of infants still received dexamethasone on less than significant respiratory support. Further research on reducing dexamethasone use in premature infants is required to decrease the risk of neurodevelopmental impairment.

Full Text

Duke Authors

Cited Authors

  • Virkud, YV; Hornik, CP; Benjamin, DK; Laughon, MM; Clark, RH; Greenberg, RG; Smith, PB

Published Date

  • April 2017

Published In

Volume / Issue

  • 183 /

Start / End Page

  • 26 - 30.e3

PubMed ID

  • 28108103

Pubmed Central ID

  • PMC5368005

Electronic International Standard Serial Number (EISSN)

  • 1097-6833

Digital Object Identifier (DOI)

  • 10.1016/j.jpeds.2016.12.035


  • eng

Conference Location

  • United States