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Respiratory Support for Very Low Birth Weight Infants Receiving Dexamethasone.

Publication ,  Journal Article
Virkud, YV; Hornik, CP; Benjamin, DK; Laughon, MM; Clark, RH; Greenberg, RG; Smith, PB
Published in: J Pediatr
April 2017

OBJECTIVE: To assess how neonatal intensive care units followed the American Academy of Pediatrics guidelines for use of dexamethasone in preterm infants by evaluating respiratory support at the time of dexamethasone administration. STUDY DESIGN: This is an observational study of infants discharged from one of 290 neonatal intensive care units from 2003 to 2010. The cohort included very low birth weight (<1500 g birth weight) infants born at ≤32 weeks gestational age. The main outcome was respiratory support at time of exposure to dexamethasone. Significant respiratory support was defined as invasive respiratory support (conventional or high-frequency ventilation) with a fraction of inspired oxygen (FiO2) > 0.3. RESULTS: Of 81 292 infants; 7093 (9%) received dexamethasone. At the time that dexamethasone was initiated, 4604 (65%) of infants were on significant respiratory support. CONCLUSIONS: In accordance with the American Academy of Pediatrics recommendations, a majority of infants were on significant respiratory support when receiving dexamethasone, yet a substantial number of infants still received dexamethasone on less than significant respiratory support. Further research on reducing dexamethasone use in premature infants is required to decrease the risk of neurodevelopmental impairment.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

April 2017

Volume

183

Start / End Page

26 / 30.e3

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Risk Assessment
  • Retrospective Studies
  • Respiratory Distress Syndrome, Newborn
  • Respiration, Artificial
  • Pediatrics
  • Odds Ratio
  • Male
  • Logistic Models
 

Citation

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Virkud, Y. V., Hornik, C. P., Benjamin, D. K., Laughon, M. M., Clark, R. H., Greenberg, R. G., & Smith, P. B. (2017). Respiratory Support for Very Low Birth Weight Infants Receiving Dexamethasone. J Pediatr, 183, 26-30.e3. https://doi.org/10.1016/j.jpeds.2016.12.035
Virkud, Yamini V., Christoph P. Hornik, Daniel K. Benjamin, Matthew M. Laughon, Reese H. Clark, Rachel G. Greenberg, and P Brian Smith. “Respiratory Support for Very Low Birth Weight Infants Receiving Dexamethasone.J Pediatr 183 (April 2017): 26-30.e3. https://doi.org/10.1016/j.jpeds.2016.12.035.
Virkud YV, Hornik CP, Benjamin DK, Laughon MM, Clark RH, Greenberg RG, et al. Respiratory Support for Very Low Birth Weight Infants Receiving Dexamethasone. J Pediatr. 2017 Apr;183:26-30.e3.
Virkud, Yamini V., et al. “Respiratory Support for Very Low Birth Weight Infants Receiving Dexamethasone.J Pediatr, vol. 183, Apr. 2017, pp. 26-30.e3. Pubmed, doi:10.1016/j.jpeds.2016.12.035.
Virkud YV, Hornik CP, Benjamin DK, Laughon MM, Clark RH, Greenberg RG, Smith PB. Respiratory Support for Very Low Birth Weight Infants Receiving Dexamethasone. J Pediatr. 2017 Apr;183:26-30.e3.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

April 2017

Volume

183

Start / End Page

26 / 30.e3

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Rate
  • Risk Assessment
  • Retrospective Studies
  • Respiratory Distress Syndrome, Newborn
  • Respiration, Artificial
  • Pediatrics
  • Odds Ratio
  • Male
  • Logistic Models