Regulation of inflammation by β-arrestins: Not just receptor tales.

Journal Article (Journal Article;Review)

The ubiquitously expressed, multifunctional scaffolding proteins β-arrestin1 and β-arrestin2 each affect inflammatory signaling in a variety of cell lines. In addition to binding the carboxyl-terminal tails of innumerable 7-transmembrane receptors, β-arrestins scaffold untold numbers of other plasma membrane and cytoplasmic proteins. Consequently, the effects of β-arrestins on inflammatory signaling are diverse, and context-specific. This review highlights the roles of β-arrestins in regulating canonical activation of the pro-inflammatory transcription factor NFκB.

Full Text

Duke Authors

Cited Authors

  • Freedman, NJ; Shenoy, SK

Published Date

  • January 2018

Published In

Volume / Issue

  • 41 /

Start / End Page

  • 41 - 45

PubMed ID

  • 28189586

Pubmed Central ID

  • PMC5550347

Electronic International Standard Serial Number (EISSN)

  • 1873-3913

Digital Object Identifier (DOI)

  • 10.1016/j.cellsig.2017.02.008


  • eng

Conference Location

  • England