Regulation of inflammation by β-arrestins: Not just receptor tales.
Published
Journal Article (Review)
The ubiquitously expressed, multifunctional scaffolding proteins β-arrestin1 and β-arrestin2 each affect inflammatory signaling in a variety of cell lines. In addition to binding the carboxyl-terminal tails of innumerable 7-transmembrane receptors, β-arrestins scaffold untold numbers of other plasma membrane and cytoplasmic proteins. Consequently, the effects of β-arrestins on inflammatory signaling are diverse, and context-specific. This review highlights the roles of β-arrestins in regulating canonical activation of the pro-inflammatory transcription factor NFκB.
Full Text
Duke Authors
Cited Authors
- Freedman, NJ; Shenoy, SK
Published Date
- January 2018
Published In
Volume / Issue
- 41 /
Start / End Page
- 41 - 45
PubMed ID
- 28189586
Pubmed Central ID
- 28189586
Electronic International Standard Serial Number (EISSN)
- 1873-3913
Digital Object Identifier (DOI)
- 10.1016/j.cellsig.2017.02.008
Language
- eng
Conference Location
- England