Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.

Published

Journal Article

Selective modulation of Rho GTPase activity in podocytes recapitulates characteristic features of human nephrosis. Using a mouse model, Robins et al. found that high levels of Rac1 activation in podocytes caused podocyte detachment and glomerulosclerosis. Podocyte Rac1 activity was enhanced in biopsy specimens from patients with nephrosis, and serum from this patient population activated Rac1 in cultured podocytes. These data provide a causal link between podocyte Rac1 activation and human nephrotic diseases.

Full Text

Duke Authors

Cited Authors

  • Hall, G; Spurney, RF

Published Date

  • August 2017

Published In

Volume / Issue

  • 92 / 2

Start / End Page

  • 283 - 285

PubMed ID

  • 28709595

Pubmed Central ID

  • 28709595

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2017.03.045

Language

  • eng

Conference Location

  • United States