Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.
Publication
, Journal Article
Hall, G; Spurney, RF
Published in: Kidney Int
August 2017
Selective modulation of Rho GTPase activity in podocytes recapitulates characteristic features of human nephrosis. Using a mouse model, Robins et al. found that high levels of Rac1 activation in podocytes caused podocyte detachment and glomerulosclerosis. Podocyte Rac1 activity was enhanced in biopsy specimens from patients with nephrosis, and serum from this patient population activated Rac1 in cultured podocytes. These data provide a causal link between podocyte Rac1 activation and human nephrotic diseases.
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Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
August 2017
Volume
92
Issue
2
Start / End Page
283 / 285
Location
United States
Related Subject Headings
- rac1 GTP-Binding Protein
- Urology & Nephrology
- Podocytes
- Nephrotic Syndrome
- Nephrosis
- Humans
- Glomerulosclerosis, Focal Segmental
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Hall, G., & Spurney, R. F. (2017). Losing their footing: Rac1 signaling causes podocyte detachment and FSGS. Kidney Int, 92(2), 283–285. https://doi.org/10.1016/j.kint.2017.03.045
Hall, Gentzon, and Robert F. Spurney. “Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.” Kidney Int 92, no. 2 (August 2017): 283–85. https://doi.org/10.1016/j.kint.2017.03.045.
Hall G, Spurney RF. Losing their footing: Rac1 signaling causes podocyte detachment and FSGS. Kidney Int. 2017 Aug;92(2):283–5.
Hall, Gentzon, and Robert F. Spurney. “Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.” Kidney Int, vol. 92, no. 2, Aug. 2017, pp. 283–85. Pubmed, doi:10.1016/j.kint.2017.03.045.
Hall G, Spurney RF. Losing their footing: Rac1 signaling causes podocyte detachment and FSGS. Kidney Int. 2017 Aug;92(2):283–285.
Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
August 2017
Volume
92
Issue
2
Start / End Page
283 / 285
Location
United States
Related Subject Headings
- rac1 GTP-Binding Protein
- Urology & Nephrology
- Podocytes
- Nephrotic Syndrome
- Nephrosis
- Humans
- Glomerulosclerosis, Focal Segmental
- 3202 Clinical sciences
- 1103 Clinical Sciences