Noninvasive measurement of tissue blood oxygenation with Cerenkov imaging during therapeutic radiation delivery.

Journal Article (Journal Article)

Tumor tissue oxygenation significantly affects the outcome of radiotherapy. Real-time monitoring of tumor hypoxia is highly desirable for effective radiotherapy, and is the basis for improved treatment because hypoxic tumor cells are more resistant to radiation damage than fully oxygenated cells. We propose to use Cerenkov imaging to monitor tumor hypoxia by means of tissue blood oxygenation without the need for any exogenous contrast agent. Using a rodent hypoxia model, we demonstrate that Cerenkov imaging can be used as a noninvasive and noncontact method to measure tissue blood oxygenation level during radiation delivery. The data from Cerenkov imaging were validated using near infrared spectrometry methods. The results demonstrate the feasibility of using Cerenkov imaging to monitor tumor hypoxia during therapeutic radiation delivery.

Full Text

Duke Authors

Cited Authors

  • Zhang, X; Lam, SK; Palmer, G; Das, S; Oldham, M; Dewhirst, M

Published Date

  • August 15, 2017

Published In

Volume / Issue

  • 42 / 16

Start / End Page

  • 3101 - 3104

PubMed ID

  • 28809883

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

Digital Object Identifier (DOI)

  • 10.1364/OL.42.003101


  • eng

Conference Location

  • United States