Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension.
The unexpected transmission of donor-derived infection through organ transplantation is a rare event with current donor screening practices. In this case report we describe a probable donor-derived transmission of Herpes Simplex Virus (HSV)-2 via deceased donor kidney transplantation resulting in HSV hepatitis in the recipient. This manifested as acute liver failure which resolved with appropriate anti-viral therapy. Following recovery from the acute liver insult, the patient developed fibrotic liver morphology and portal hypertension, an unusual departure from the typical course.
Shaw, BI; Nanavati, AJ; Taylor, V; Miller, RA; Kappus, M; Barbas, AS
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