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Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension.

Publication ,  Journal Article
Shaw, BI; Nanavati, AJ; Taylor, V; Miller, RA; Kappus, M; Barbas, AS
Published in: Transpl Infect Dis
February 2019

The unexpected transmission of donor-derived infection through organ transplantation is a rare event with current donor screening practices. In this case report we describe a probable donor-derived transmission of Herpes Simplex Virus (HSV)-2 via deceased donor kidney transplantation resulting in HSV hepatitis in the recipient. This manifested as acute liver failure which resolved with appropriate anti-viral therapy. Following recovery from the acute liver insult, the patient developed fibrotic liver morphology and portal hypertension, an unusual departure from the typical course.

Duke Scholars

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

February 2019

Volume

21

Issue

1

Start / End Page

e13029

Location

Denmark

Related Subject Headings

  • Treatment Outcome
  • Surgery
  • Liver Failure, Acute
  • Liver Cirrhosis
  • Liver
  • Kidney Transplantation
  • Kidney
  • Hypertension, Portal
  • Humans
  • Herpesvirus 2, Human
 

Citation

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Chicago
ICMJE
MLA
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Shaw, B. I., Nanavati, A. J., Taylor, V., Miller, R. A., Kappus, M., & Barbas, A. S. (2019). Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension. Transpl Infect Dis, 21(1), e13029. https://doi.org/10.1111/tid.13029
Shaw, Brian I., Aditya J. Nanavati, Vanessa Taylor, Rachel A. Miller, Matthew Kappus, and Andrew S. Barbas. “Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension.Transpl Infect Dis 21, no. 1 (February 2019): e13029. https://doi.org/10.1111/tid.13029.
Shaw BI, Nanavati AJ, Taylor V, Miller RA, Kappus M, Barbas AS. Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension. Transpl Infect Dis. 2019 Feb;21(1):e13029.
Shaw, Brian I., et al. “Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension.Transpl Infect Dis, vol. 21, no. 1, Feb. 2019, p. e13029. Pubmed, doi:10.1111/tid.13029.
Shaw BI, Nanavati AJ, Taylor V, Miller RA, Kappus M, Barbas AS. Donor derived HSV hepatitis in a kidney transplant recipient leading to liver fibrosis and portal hypertension. Transpl Infect Dis. 2019 Feb;21(1):e13029.
Journal cover image

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

February 2019

Volume

21

Issue

1

Start / End Page

e13029

Location

Denmark

Related Subject Headings

  • Treatment Outcome
  • Surgery
  • Liver Failure, Acute
  • Liver Cirrhosis
  • Liver
  • Kidney Transplantation
  • Kidney
  • Hypertension, Portal
  • Humans
  • Herpesvirus 2, Human