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Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.

Publication ,  Journal Article
Liu, Y; Carpenter, AB; Pirozzi, CJ; Yuan, H; Waitkus, MS; Zhou, Z; Hansen, L; Seywald, M; Odion, R; Greer, PK; Hawk, T; Chin, BB; Yan, H ...
Published in: Nanotechnology
July 5, 2019

Despite decades of efforts, non-invasive sensitive detection of small malignant brain tumors still remains challenging. Here we report a dual-modality 124I-labeled gold nanostar (124I-GNS) probe for sensitive brain tumor imaging with positron emission tomography (PET) and subcellular tracking with two-photon photoluminescence (TPL) and electron microscopy (EM). Experiment results showed that the developed nanoprobe has potential to reach sub-millimeter intracranial brain tumor detection using PET scan, which is superior to any currently available non-invasive imaging modality. Microscopic examination using TPL and EM further confirmed that GNS nanoparticles permeated the brain tumor leaky vasculature and accumulated inside brain tumor cells following systemic administration. Selective brain tumor targeting by enhanced permeability and retention effect and ultrasensitive imaging render 124I-GNS nanoprobe promise for future brain tumor-related preclinical and translational applications.

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Published In

Nanotechnology

DOI

EISSN

1361-6528

Publication Date

July 5, 2019

Volume

30

Issue

27

Start / End Page

275101

Location

England

Related Subject Headings

  • Positron Emission Tomography Computed Tomography
  • Organ Specificity
  • Optical Imaging
  • Nanoscience & Nanotechnology
  • Mice
  • Metal Nanoparticles
  • Iodine Radioisotopes
  • Humans
  • HEK293 Cells
  • Gold
 

Citation

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Liu, Y., Carpenter, A. B., Pirozzi, C. J., Yuan, H., Waitkus, M. S., Zhou, Z., … Vo-Dinh, T. (2019). Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe. Nanotechnology, 30(27), 275101. https://doi.org/10.1088/1361-6528/ab0e9c
Liu, Yang, Austin B. Carpenter, Christopher J. Pirozzi, Hsiangkuo Yuan, Matthew S. Waitkus, Zhengyuan Zhou, Landon Hansen, et al. “Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.Nanotechnology 30, no. 27 (July 5, 2019): 275101. https://doi.org/10.1088/1361-6528/ab0e9c.
Liu Y, Carpenter AB, Pirozzi CJ, Yuan H, Waitkus MS, Zhou Z, et al. Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe. Nanotechnology. 2019 Jul 5;30(27):275101.
Liu, Yang, et al. “Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.Nanotechnology, vol. 30, no. 27, July 2019, p. 275101. Pubmed, doi:10.1088/1361-6528/ab0e9c.
Liu Y, Carpenter AB, Pirozzi CJ, Yuan H, Waitkus MS, Zhou Z, Hansen L, Seywald M, Odion R, Greer PK, Hawk T, Chin BB, Vaidyanathan G, Zalutsky MR, Yan H, Vo-Dinh T. Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe. Nanotechnology. 2019 Jul 5;30(27):275101.
Journal cover image

Published In

Nanotechnology

DOI

EISSN

1361-6528

Publication Date

July 5, 2019

Volume

30

Issue

27

Start / End Page

275101

Location

England

Related Subject Headings

  • Positron Emission Tomography Computed Tomography
  • Organ Specificity
  • Optical Imaging
  • Nanoscience & Nanotechnology
  • Mice
  • Metal Nanoparticles
  • Iodine Radioisotopes
  • Humans
  • HEK293 Cells
  • Gold